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FUNBIT SIGNED

Imaging Mass Spectrometry of Fungal – Bacterial Interplay

Total Cost €

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EC-Contrib. €

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Partnership

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 FUNBIT project word cloud

Explore the words cloud of the FUNBIT project. It provides you a very rough idea of what is the project "FUNBIT" about.

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Project "FUNBIT" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT 

Organization address
address: BEUTENBERG STRASSE 11A
city: JENA
postcode: 7745
website: http://www2.hki-jena.de/rz/hki_i00.htm

contact info
title: n.a.
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surname: n.a.
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 Coordinator Country Germany [DE]
 Project website http://funbitproject.blogspot.de/
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) coordinator 159˙460.00

Map

 Project objective

FUNBIT aims to enhance the discovery rate of natural products applying a multidisciplinary workflow guided by Imaging MS.

Microbial genetics predict that the natural products we have discovered so far are only the tip of the iceberg, thus we may be missing the antibiotics and biopesticides of the future. In fact, many natural compounds remain invisible under standard laboratory conditions, but their biosynthesis can be triggered by re-establishing the structure of their native community in multi-microbial co-cultures. Thus, hidden natural products that enable microbes to communicate and compete with each other can be revealed. However, microbial interkingdom partnerships such as fungi-bacterial microbial interactions are still in general poorly explored. The detection of cryptic natural products from microorganisms is a major challenge because many of them are produced in small quantities, in a specific area and during a short period of time. The emerging technology of Imaging Mass Spectrometry can be the best candidate to investigate multi-partner microbial interactions in their native ecological environment, and find the natural products involved in their cross-talk. FUNBIT aims to speed up the rate of natural product discovery (especially polyketides, and lipopeptides, since many antibiotics fall into these groups) by integrating Imaging MS with High Resolution MS, spatial statistics and molecular network analysis. We will focus on fungi-bacterial partnerships involved in important agricultural infections, such as root diseases. These microorganisms are safer to handle, but the discovered antibiotics and antifungals will potentially target human pathogens. FUNBIT will be supervised by Prof. Christian Hertweck, who was awarded in 2015 with the Gottfried Wilhelm Leibniz Prize for his expertise in natural products. FUNBIT will be developed at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) in Jena (Germany).

 Publications

year authors and title journal last update
List of publications.
2017 Philip Brandt, María García-Altares, Markus Nett, Christian Hertweck, Dirk Hoffmeister
Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase
published pages: 5937-5941, ISSN: 1433-7851, DOI: 10.1002/anie.201700767
Angewandte Chemie International Edition 56/21 2019-06-13
2016 Huijuan Guo, Nina B. Kreuzenbeck, Saria Otani, Maria Garcia-Altares, Hans-Martin Dahse, Christiane Weigel, Duur K. Aanen, Christian Hertweck, Michael Poulsen, Christine Beemelmanns
Pseudoxylallemycins A–F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802: A Competitor of Fungus-Growing Termite Cultivars
published pages: 3338-3341, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01437
Organic Letters 18/14 2019-06-13

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