Opendata, web and dolomites

PreventStoCan SIGNED

Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PreventStoCan project word cloud

Explore the words cloud of the PreventStoCan project. It provides you a very rough idea of what is the project "PreventStoCan" about.

worldwide    amplification    molecular    diagnosis    reducing    predict    profiles    epigenetic    archived    tests    cancer    carcinogenic    matched    perform    microorganisms    infection    significantly    risk    stomach    dissection    burden    broaden    gastric    malignancy    microenvironment    determines    historic    death    door    prevention    environmental    carcinogenicity    controls    mutation    material    metagenomic    identification    laser    infections    composition    decades    4th    groups    2nd    exposures    variation    stratification    interactions    sequencing    checked    genotypic    microbiome    hypothesize    vast    mechanisms    hypotheses    inflammation    invading    nested    resource    index    materials    explore    amount    host    mechanism    minute    patients    micro    examine    easily    ago    biopsy    time    carcinogenesis    blocks    capture    starting    dna    pathology    probiotic    cohort    paraffin    underlying    changed    biopsies    retrieved    deepen    microbe    dreaded    longer    pharmacological    strains    invasive    countries    displaced    microfloras    pylori    linking    causing   

Project "PreventStoCan" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙941˙531 €
 EC max contribution 1˙941˙531 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙941˙531.00

Map

 Project objective

Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related death worldwide. The aim of this proposal is to deepen the understanding of mechanisms involved in microbe-induced gastric carcinogenesis, which will facilitate risk stratification for identification of high-risk groups and may offer new opportunities for pharmacological and probiotic prevention. We hypothesize that novel H. pylori genotypic variation can predict carcinogenicity. The cancer-causing H. pylori strains may no longer be present at the time of cancer diagnosis, displaced by a changed microenvironment and invading microorganisms. We further hypothesize that the composition of invading microorganisms determines the risk of stomach cancer. To test these hypotheses, we will perform a case-control study nested within a historic cohort of patients with gastric biopsies taken decades ago. For cases who developed stomach cancer several years after index biopsy and their matched controls, paraffin-embedded blocks will be retrieved for metagenomic analysis of H. pylori and other microfloras, using our new method with laser capture micro-dissection, DNA amplification and sequencing. Interactions of host response and environmental exposures with the gastric microbiome will also be checked. To explore the molecular mechanism underlying the gastric carcinogenesis, we will further examine gastric epigenetic changes and mutation profiles by novel methods which require minute amount of starting material. Moreover, we will develop non-invasive tests for infections with carcinogenic strains of H. pylori and other microorganisms, which can easily be deployed in low-resource countries. This project will not only contribute significantly to reducing the worldwide burden of this dreaded malignancy, but also broaden our understanding of the mechanisms linking infection, inflammation and cancer development, and open a door for research using the vast resources of archived pathology materials.

 Publications

year authors and title journal last update
List of publications.
2017 Huan Song, Isabella Guncha Ekheden, Alexander Ploner, Jan Ericsson, Olof Nyren, Weimin Ye
Family history of gastric mucosal abnormality and the risk of gastric cancer: a population-based observational study
published pages: , ISSN: 0300-5771, DOI: 10.1093/ije/dyx238
International Journal of Epidemiology 2019-06-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PREVENTSTOCAN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PREVENTSTOCAN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EVOMENS (2020)

The evolution of menstruation in primates

Read More  

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

DYMOLAMO (2018)

Dynamic Modeling of Labor Market Mobility and Human Capital Accumulation

Read More