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PreventStoCan SIGNED

Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention

Total Cost €

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EC-Contrib. €

0

Partnership

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 PreventStoCan project word cloud

Explore the words cloud of the PreventStoCan project. It provides you a very rough idea of what is the project "PreventStoCan" about.

infections    profiles    microbe    biopsy    perform    predict    mechanism    gastric    ago    countries    mechanisms    environmental    materials    explore    genotypic    reducing    pylori    malignancy    tests    checked    metagenomic    door    paraffin    infection    changed    burden    dissection    historic    amount    invasive    groups    prevention    laser    death    invading    dna    causing    2nd    vast    pharmacological    material    micro    hypotheses    deepen    mutation    diagnosis    microorganisms    carcinogenicity    4th    composition    index    broaden    molecular    variation    carcinogenesis    identification    probiotic    patients    matched    stratification    capture    longer    controls    blocks    worldwide    underlying    risk    carcinogenic    determines    exposures    microfloras    cancer    archived    examine    cohort    amplification    retrieved    significantly    starting    epigenetic    displaced    inflammation    interactions    hypothesize    decades    sequencing    resource    minute    host    linking    pathology    strains    microbiome    easily    biopsies    nested    time    dreaded    microenvironment    stomach   

Project "PreventStoCan" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙941˙531 €
 EC max contribution 1˙941˙531 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙941˙531.00

Map

 Project objective

Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related death worldwide. The aim of this proposal is to deepen the understanding of mechanisms involved in microbe-induced gastric carcinogenesis, which will facilitate risk stratification for identification of high-risk groups and may offer new opportunities for pharmacological and probiotic prevention. We hypothesize that novel H. pylori genotypic variation can predict carcinogenicity. The cancer-causing H. pylori strains may no longer be present at the time of cancer diagnosis, displaced by a changed microenvironment and invading microorganisms. We further hypothesize that the composition of invading microorganisms determines the risk of stomach cancer. To test these hypotheses, we will perform a case-control study nested within a historic cohort of patients with gastric biopsies taken decades ago. For cases who developed stomach cancer several years after index biopsy and their matched controls, paraffin-embedded blocks will be retrieved for metagenomic analysis of H. pylori and other microfloras, using our new method with laser capture micro-dissection, DNA amplification and sequencing. Interactions of host response and environmental exposures with the gastric microbiome will also be checked. To explore the molecular mechanism underlying the gastric carcinogenesis, we will further examine gastric epigenetic changes and mutation profiles by novel methods which require minute amount of starting material. Moreover, we will develop non-invasive tests for infections with carcinogenic strains of H. pylori and other microorganisms, which can easily be deployed in low-resource countries. This project will not only contribute significantly to reducing the worldwide burden of this dreaded malignancy, but also broaden our understanding of the mechanisms linking infection, inflammation and cancer development, and open a door for research using the vast resources of archived pathology materials.

 Publications

year authors and title journal last update
List of publications.
2017 Huan Song, Isabella Guncha Ekheden, Alexander Ploner, Jan Ericsson, Olof Nyren, Weimin Ye
Family history of gastric mucosal abnormality and the risk of gastric cancer: a population-based observational study
published pages: , ISSN: 0300-5771, DOI: 10.1093/ije/dyx238
International Journal of Epidemiology 2019-06-18

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The information about "PREVENTSTOCAN" are provided by the European Opendata Portal: CORDIS opendata.

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