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GUPPYSEX SIGNED

Evolutionary genetics of guppy sex chromosomes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GUPPYSEX project word cloud

Explore the words cloud of the GUPPYSEX project. It provides you a very rough idea of what is the project "GUPPYSEX" about.

sexes    emerge    chromosome    chromosomes    modifers    individuals    gene    linked    gain    mutations    mapped    differing    markers    guppy    expression    allele    sexual    suppressed    estimate    fundamental    age    hypothesis    plausible    region    guppies    xx    sa    male    sequence    fish    versus    lower    gaps    thought    divergence    rates    populations    predicted    direct    evolutionary    males    genes    reduce    expertise    arise    females    multiple    group    natural    map    sex    collaborators    lacks    first    predictions    conflict    behavioural    pseudo    genetics    fitness    autosomal    poecilia    conspicuous    coloration    complement    phenotypes    polymorphisms    predators    population    frequencies    fill    antagonism    team    regimes    assembled    par    tests    documented    compensating    recombination    attractive    carries    genetic    linkage    benefit    strength    evolution    predation    dna    molecular    unless    ideal    reticulata    complicated    closer    ecological   

Project "GUPPYSEX" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙550˙235 €
 EC max contribution 1˙550˙235 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 930˙607.00
2    THE UNIVERSITY OF EXETER UK (EXETER) participant 619˙627.00

Map

 Project objective

I propose an integrated programme of molecular genetic studies to fill fundamental gaps in our knowledge of sex chromosome evolution. Specifically, I will use a fish, the guppy (Poecilia reticulata), to test the sexual antagonism (SA) hypothesis of sex chromosome evolution, which is plausible, but lacks direct evidence. SA mutations (that benefit one sex but lower fitness of the other) are proposed to arise in a partially sex-linked (pseudo-autosomal region, or PAR) gene, and establish polymorphisms. To reduce the conflict between the sexes, suppressed recombination between X and Y chromosomes then evolves (unless sex-specific expression evolves first). The guppy is ideal for studying this hypothesis because SA polymorphisms are well documented: male coloration phenotypes make males attractive to females, but also make them conspicuous to predators (while females gain no compensating benefit). Moreover, guppies have a recombination-suppressed sex-linked region that carries multiple coloration genes, yet is thought to have evolved recently. However, no non-Y-linked coloration factor has yet been mapped, and the genetics is complicated by modifers making some XX individuals male, and by male-specific expression of some phenotypes. I will map coloration genes and identify PAR genes using DNA-based markers to take account of these problems. I will test for the predicted lower coloration allele frequencies in natural populations with high versus low predation rates, and do population genetic analyses to test for closer linkage under high predation. I will also use X-Y sequence divergence to estimate the age of the guppy sex chromosome. The project tests predictions that emerge from well-documented differing selection regimes in natural guppy populations. I have therefore assembled a team of collaborators experienced with guppies who can provide behavioural and ecological genetic expertise to complement the strength of my own group in molecular evolutionary genetics.

 Publications

year authors and title journal last update
List of publications.
2018 Tim Connallon, Colin Olito, Ludovic Dutoit, Homa Papoli, Filip Ruzicka, Lengxob Yong
Local adaptation and the evolution of inversions on sex chromosomes and autosomes
published pages: 20170423, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0423
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1757 2020-01-24
2018 Deborah Charlesworth
The Guppy Sex Chromosome System and the Sexually Antagonistic Polymorphism Hypothesis for Y Chromosome Recombination Suppression
published pages: 264, ISSN: 2073-4425, DOI: 10.3390/genes9050264
Genes 9/5 2020-01-24

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