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CardAPcells

Cell therapy for patients with chronic heart failure with proprietary cardiac-derived cells (CardAP cells) – “From the Heart to the Heart”

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CardAPcells project word cloud

Explore the words cloud of the CardAPcells project. It provides you a very rough idea of what is the project "CardAPcells" about.

donor cells usually facilities bridge perform market heart limited 45 eacute approval patients safety cardiac achievements severe life hearts mio stromal 22 therapy transferred specialized off worldwide progressive gmp suffer medicine area germany fulfilment manufacturing curative exemption regulation plan trial chronic cardiomyopathy insufficiency projected efficacy finalised introduction artificial cellserve threatening die acquired multicenter except exclusive advantages preparations university therapies equity fulfil solution business financing preparation criteria 140 atmp spin therapeutic rare stress hospital disease cardap financial atmps clinical competitors suffering morbidity cure regulatory license stem commercial models people completely mortality charit cell calculations preliminary

Project "CardAPcells" data sheet

The following table provides information about the project.

Coordinator	CELLSERVE GMBH Organization address address: CHARITEPLATZ 1 city: BERLIN postcode: 10117 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.cellserve.de/
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-1-2016-2017
Funding Scheme	SME-1
Starting year	2016
Duration (year-month-day)	from 2016-07-01 to 2016-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CELLSERVE GMBH CELLSERVE GMBH Organization address address: CHARITEPLATZ 1 city: BERLIN postcode: 10117 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	coordinator	50˙000.00

Map

Project objective

Chronic heart failure is a life-threatening disease usually without cure and a leading cause of morbidity and mortality. In Germany 45 000 patients (projected to EU: about 140 000) die every year from progressive chronic cardiac insufficiency. There is no curative therapeutic solution, except very rare donor hearts and artificial hearts as bridge devices. Researchers at the Charité - University Medicine, have identified unique cardiac-specific stromal cells (CardAP cells) with strong efficacy in cardiac stress models. CardAP cells are specialized heart-derived cells with key advantages in safety and efficacy. CardAP cells fulfil all criteria for cardiac cell therapy and cell product manufacturing has been transferred to GMP facilities. CellServe, a Charité spin off, will develop the CardAP cells for therapy of patients suffering from severe life-threatening cardiomyopathy. CellServe has acquired an exclusive license of this technology and will perform a clinical phase I/II study for patients with chronic cardiomyopathy. The technology of CellServe is completely distinct from all competitors, using specialized stromal heart cells and not stem cells.

CellServe has an experienced management in cell-based therapies area to develop and market ATMP products. It will apply for a so-called hospital exemption regulation, a limited preliminary approval, for early market introduction directly after the clinical study. Commercial potential: Worldwide 22 Mio people suffer from chronic cardiac insufficiency. â€¨ In Phase 1 a business plan for the CardAP cell product will be generated including financial calculations and the preparations for the clinical study will be finalised.â€¨ Achievements Phase 2:â€¨• Phase I/II clinical trialâ€¨• Approval for Hospital Exemption for ATMPsâ€¨• Preparation of a multicenter clinical trialâ€¨• Fulfilment of all regulatory requirements to perform a phase III clinical studyâ€¨• Equity financing

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The information about "CARDAPCELLS" are provided by the European Opendata Portal: CORDIS opendata.

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