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CardAPcells

Cell therapy for patients with chronic heart failure with proprietary cardiac-derived cells (CardAP cells) – “From the Heart to the Heart”

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 CardAPcells project word cloud

Explore the words cloud of the CardAPcells project. It provides you a very rough idea of what is the project "CardAPcells" about.

45    completely    mortality    mio    preliminary    donor    stem    stress    disease    finalised    off    multicenter    trial    hearts    equity    efficacy    spin    approval    regulatory    suffering    acquired    projected    rare    severe    heart    regulation    commercial    competitors    criteria    calculations    morbidity    cure    cell    preparations    specialized    charit    bridge    life    usually    insufficiency    atmps    business    patients    market    chronic    transferred    except    preparation    financing    people    stromal    hospital    progressive    safety    exemption    curative    cardiomyopathy    therapy    atmp    therapies    germany    clinical    financial    manufacturing    limited    worldwide    fulfilment    area    advantages    exclusive    license    models    140    die    introduction    artificial    cardap    22    facilities    eacute    gmp    achievements    solution    cardiac    cells    therapeutic    threatening    university    medicine    cellserve    suffer    fulfil    perform    plan   

Project "CardAPcells" data sheet

The following table provides information about the project.

Coordinator		 CELLSERVE GMBH 

Organization address
address: CHARITEPLATZ 1
city: BERLIN
postcode: 10117
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website http://www.cellserve.de/
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2016-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CELLSERVE GMBH DE (BERLIN) coordinator 50˙000.00

Map

 Project objective

Chronic heart failure is a life-threatening disease usually without cure and a leading cause of morbidity and mortality. In Germany 45 000 patients (projected to EU: about 140 000) die every year from progressive chronic cardiac insufficiency. There is no curative therapeutic solution, except very rare donor hearts and artificial hearts as bridge devices. Researchers at the Charité - University Medicine, have identified unique cardiac-specific stromal cells (CardAP cells) with strong efficacy in cardiac stress models. CardAP cells are specialized heart-derived cells with key advantages in safety and efficacy. CardAP cells fulfil all criteria for cardiac cell therapy and cell product manufacturing has been transferred to GMP facilities. CellServe, a Charité spin off, will develop the CardAP cells for therapy of patients suffering from severe life-threatening cardiomyopathy. CellServe has acquired an exclusive license of this technology and will perform a clinical phase I/II study for patients with chronic cardiomyopathy. The technology of CellServe is completely distinct from all competitors, using specialized stromal heart cells and not stem cells.

CellServe has an experienced management in cell-based therapies area to develop and market ATMP products. It will apply for a so-called hospital exemption regulation, a limited preliminary approval, for early market introduction directly after the clinical study. Commercial potential: Worldwide 22 Mio people suffer from chronic cardiac insufficiency. 
 In Phase 1 a business plan for the CardAP cell product will be generated including financial calculations and the preparations for the clinical study will be finalised.
 Achievements Phase 2:
• Phase I/II clinical trial
• Approval for Hospital Exemption for ATMPs
• Preparation of a multicenter clinical trial
• Fulfilment of all regulatory requirements to perform a phase III clinical study
• Equity financing

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CARDAPCELLS" project.

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The information about "CARDAPCELLS" are provided by the European Opendata Portal: CORDIS opendata.

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