Opendata, web and dolomites

GRADIENTSENSING SIGNED

Cellular navigation along spatial gradients

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GRADIENTSENSING project word cloud

Explore the words cloud of the GRADIENTSENSING project. It provides you a very rough idea of what is the project "GRADIENTSENSING" about.

chemokines    diverse    cell    cues    engineer    newly    emerge    tractable    quantitative    discoideum    inferred    convergent    cyclicamp    soluble    suitable    interpreted    immunology    biological    genetic    molecules    paradigms    complementary    microscopy    mechanistic    guidance    fundamental    principles    leukocyte    contribution    engineered    biology    spatiotemporal    immobilized    migrating    depends    differences    extracellular    spatial    editing    central    haptotaxis    employing    family    sensing    persistent    combination    image    genome    question    signals    specify    relevance    function    leukocytes    direction    validated    chemotaxis    concentration    primary    assaying    migration    guarantee    permanently    triggered    optogenetically    directionally    orchestration    motile    critically    holistic    dictyostelium    malignancy    proteins    tools    immunity    signalling    shapes    vivo    physiological    amoeba    chemokine    position    cells    immune    gradients    shape    first    gradient    temporal    eukaryotic    genetically    screen    engineering    precision    suggest    responding    cancer    perform    intravital    cellular   

Project "GRADIENTSENSING" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙984˙922 €
 EC max contribution 1˙984˙922 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙984˙922.00

Map

 Project objective

Gradients of extracellular signalling molecules are a central concept in biology: for example gradients of guidance-cues such as chemokines position migrating cells in development, malignancy and immunity. Because immune cells are permanently motile, their function most critically depends on spatiotemporal orchestration by a large family of chemokines. To specify direction, concentration differences of the chemokine need to be interpreted by the migrating cell. Most mechanistic knowledge about eukaryotic gradient sensing is inferred from the amoeba Dictyostelium discoideum migrating towards soluble gradients of cyclicAMP. The biology of chemokines is much more diverse, e.g. gradients can take different shapes and, importantly, they do not only emerge in the soluble but also in the immobilized phase. In this proposal we suggest to address the principles of leukocyte chemotaxis using convergent system wide, cell biological and intravital approaches. Employing a newly developed, genetically tractable primary leukocyte system, we will test the contribution of spatial and temporal signalling paradigms of gradient sensing. Quantitative microscopy will be used to image cellular responses to engineered immobilized and soluble chemokine gradients of defined shape as well as to optogenetically triggered signals. In a complementary approach we will screen for proteins responding to chemokine signalling and perform the first genome wide genome editing-based loss of function screen for directionally persistent chemotaxis and haptotaxis. Findings will be validated in vivo to guarantee physiological relevance. In a support project we will precision-engineer the genome of primary leukocytes suitable for assaying migration. A unique combination of cellular, genetic, engineering and quantitative microscopy tools will allow this new and holistic approach to a question which is not only fundamental for immunology but also for understanding development and cancer biology.

 Publications

year authors and title journal last update
List of publications.
2019 Jörg Renkawitz, Aglaja Kopf, Julian Stopp, Ingrid de Vries, Meghan K. Driscoll, Jack Merrin, Robert Hauschild, Erik S. Welf, Gaudenz Danuser, Reto Fiolka, Michael Sixt
Nuclear positioning facilitates amoeboid migration along the path of least resistance
published pages: 546-550, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1087-5
Nature 568/7753 2020-03-23
2018 Miroslav Hons, Aglaja Kopf, Robert Hauschild, Alexander Leithner, Florian Gaertner, Jun Abe, Jörg Renkawitz, Jens V. Stein, Michael Sixt
Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells
published pages: 606-616, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0109-z
Nature Immunology 19/6 2020-03-23
2018 Alexander Leithner, Joerg Renkawitz, Ingrid De Vries, Robert Hauschild, Hans Häcker, Michael Sixt
Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration
published pages: 1074-1077, ISSN: 0014-2980, DOI: 10.1002/eji.201747358
European Journal of Immunology 48/6 2020-03-23

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GRADIENTSENSING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GRADIENTSENSING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

CARBYNE (2020)

New carbon reactivity rules for molecular editing

Read More