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GermlineAgeingSoma SIGNED

Getting to the root of ageing: somatic decay as a cost of germline maintenance

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EC-Contrib. €

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Project "GermlineAgeingSoma" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF EAST ANGLIA 

Organization address
address: EARLHAM ROAD
city: NORWICH
postcode: NR4 7TJ
website: http://www.uea.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF EAST ANGLIA UK (NORWICH) coordinator 2˙000˙000.00

Map

 Project objective

The trade-off between survival and reproduction lies at the core of the evolutionary theory of ageing. Removal of germ cells extends somatic lifespan implying that reduced reproduction frees up resources for survival. Remarkably, however, the disruption of germline signalling increases lifespan without the obligatory reduction in fecundity, thus challenging the key role of the survival-reproduction trade-off. Recent breakthroughs suggest that protection and repair of the genome and the proteome of the germ cells is costly and compromised germline maintenance increases mutation rate, which can reduce offspring fitness. Thus, expensive germline maintenance can be a missing link in the puzzle of cost-free lifespan extension. This hypothesis predicts that when germline signalling is manipulated to increase investment into somatic cells, the germline maintenance will suffer resulting in increased mutation rate and reduced offspring fitness, even if total fecundity is unaffected. I propose a research program at the interface of evolutionary biology and biogerontology that focuses on phenotypic and evolutionary costs of germline maintenance. First, I will genetically manipulate germline signalling to boost investment into soma and estimate mutation rate and competitive fitness of the resulting offspring using Caenorhabditis elegans nematodes. Second, I will employ experimental evolution in nematodes to assess the long-term evolutionary costs of increased germline maintenance. Third, I will use germline transplantation in zebrafish Dario rerio to directly test whether germline proliferation reduces investment into soma in a vertebrate. Understanding how increased investment into the soma damages the germline and reduces offspring fitness will provide a major advance in our understanding of ageing evolution and will have serious implications for applied research programs aimed at harnessing the power of germline signalling to postpone ageing.

 Publications

year authors and title journal last update
List of publications.
2019 Martin I. Lind, Sanjana Ravindran, Zuzana Sekajova, Hanne Carlsson, Andrea Hinas, Alexei A. Maklakov
Experimentally reduced insulin/IGF-1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring
published pages: 207-216, ISSN: 2056-3744, DOI: 10.1002/evl3.108
Evolution Letters 3/2 2019-08-05
2018 Robert M. Griffin, Adam D. Hayward, Elisabeth Bolund, Alexei A. Maklakov, Virpi Lummaa
Sex differences in adult mortality rate mediated by early-life environmental conditions
published pages: 235-242, ISSN: 1461-023X, DOI: 10.1111/ele.12888
Ecology Letters 21/2 2019-08-05
2018 Felix Zajitschek, Grigorios Georgolopoulos, Anna Vourlou, Maja Ericsson, Susanne R K Zajitschek, Urban Friberg, Alexei A Maklakov
Evolution Under Dietary Restriction Decouples Survival From Fecundity in Drosophila melanogaster Females
published pages: , ISSN: 1079-5006, DOI: 10.1093/gerona/gly070
The Journals of Gerontology: Series A 2019-08-05

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