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LUPUSCARE SIGNED

PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Total Cost €

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EC-Contrib. €

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Partnership

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 LUPUSCARE project word cloud

Explore the words cloud of the LUPUSCARE project. It provides you a very rough idea of what is the project "LUPUSCARE" about.

perturbation    genome    150    genomics    hypothesis    organ    track    allowed    lupus    systemic    glimpse    mutations    female    diagnosis    monitoring    microbiota    severity    omics    paradigm    shift    boundaries    epigenetic    culminating    phenotypes    chip    trait    interplay    hyperactivity    impacts    expression    throughput    stem    whereby    participate    fundamental    sequencing    diagnostics    pathogenesis    matrices    abnormalities    disease    hscs    models    erythematosus    mechanism    constituents    recognizes    correlation    elucidated    sle    profile    bone    experimental    molecular    originate    patients    homeostasis    varying    taxonomy    unifying    environmental    pathogenetic    trials    trios    staggering    risk    questions    insights    somatic    clinical    lie    immune    laid    pursuing    editing    gene    cells    technologies    initial    integrate    validate    humanized    ask    tissue    lymphoma    immunotherapy    genetic    gender    therapy    elaborate    hematopoietic    predominance    characterization    personalized    maintains    utility    foundations    networks    animal    extends    biology    cell    therapeutic    heterogeneous    marrow    data    rna    record    systematic    single    diverse    innovative    autoimmunity    device    genomic    self    epigenomic    biological    panels    trial    family    combination    examine   

Project "LUPUSCARE" data sheet

The following table provides information about the project.

Coordinator
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON 

Organization address
address: SORANOU EFESIOU 4
city: ATHINA
postcode: 115 27
website: www.bioacademy.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 2˙355˙000 €
 EC max contribution 2˙355˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) coordinator 2˙355˙000.00

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 Project objective

Systemic lupus erythematosus (SLE) is a heterogeneous disease whereby an interplay of environmental, genetic and epigenetic factors lead to perturbation of complex biological networks culminating into diverse clinical phenotypes of varying severity. High throughput methods have allowed an “initial glimpse” into pathogenesis and have laid the foundations for a molecular-based taxonomy for personalized therapy. Based on our experience with the molecular characterization of SLE, a recently completed RNA sequencing analysis of 150 patients, and our track- record of “paradigm shift” trials in SLE, we will integrate data from multi-tissue analyses with novel technologies to improve its diagnosis, monitoring and therapy, and ask fundamental pathogenetic questions in systemic autoimmunity. More specifically, we will design gene expression panels and “expression profile”/”clinical trait” correlation matrices for diagnostics, personalized immunotherapy and improved clinical trial design. In a systematic multi-tissue approach, we will examine the role of somatic mutations in enhancing immune hyperactivity and the risk for lymphoma. The staggering (7-9:1) female predominance will be elucidated through elaborate genomic, epigenomic and microbiota analyses of family trios. Finally, we will be pursuing the innovative hypothesis that the fundamental abnormalities of SLE lie within the bone marrow hematopoietic stem cells (HSCs) - from which all cells that participate in the pathogenesis of SLE originate - and establish it as a unifying pathogenetic mechanism. By a combination of novel experimental analyses with single cell genomics, multi–omics, humanized animal models, genome editing and an “organ on-a-chip” device, we will validate HSCs as a therapeutic target. The utility of SLE research extends beyond its boundaries, by providing unique insights as to how the immune system recognizes self-constituents and maintains its homeostasis, and how gender impacts on disease biology.

 Publications

year authors and title journal last update
List of publications.
2019 Grigoriou Maria
RNA-sequencing and transcriptome analysis of hematopoietic stem cells in systemic lupus erythematosus
published pages: , ISSN: , DOI:
2020-04-24
2019 Nikolaos I Panousis, George K Bertsias, Halit Ongen, Irini Gergianaki, Maria G Tektonidou, Maria Trachana, Luciana Romano-Palumbo, Deborah Bielser, Cedric Howald, Cristina Pamfil, Antonis Fanouriakis, Despoina Kosmara, Argyro Repa, Prodromos Sidiropoulos, Emmanouil T Dermitzakis, Dimitrios T Boumpas
Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity
published pages: 1079-1089, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-214379
Annals of the Rheumatic Diseases 78/8 2020-04-15
2020 D Nikolopoulos, M Kostopoulou, A Pieta, T Karageorgas, D Tseronis, K Chavatza, S Flouda, P Rapsomaniki, A Banos, E Kremasmenou, V Tzavara, P Katsimbri, A Fanouriakis, D T Boumpas
Evolving phenotype of systemic lupus erythematosus in Caucasians: low incidence of lupus nephritis, high burden of neuropsychiatric disease and increased rates of late-onset lupus in the ‘Attikon’ cohort
published pages: 96120332090893, ISSN: 0961-2033, DOI: 10.1177/0961203320908932
Lupus 2020-03-11
2019 Maria Grigoriou, Aggelos Banos, Anastasia Filia, Pavlos Pavlidis, Stavroula Giannouli, Vassiliki Karali, Dionysis Nikolopoulos, Antigone Pieta, George Bertsias, Panayotis Verginis, Ioannis Mitroulis, Dimitrios T Boumpas
Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus
published pages: annrheumdis-2019, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2019-215782
Annals of the Rheumatic Diseases 2020-01-30
2018 Katerina Gkirtzimanaki, Eleni Kabrani, Dimitra Nikoleri, Alexander Polyzos, Athanasios Blanas, Prodromos Sidiropoulos, Antonis Makrigiannakis, George Bertsias, Dimitrios T. Boumpas, Panayotis Verginis
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion
published pages: 921-933.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.001
Cell Reports 25/4 2019-04-16
2018 E.A.A. Christou, A. Banos, D. Kosmara, GK Bertsias, DT Boumpas
Sexual dimorphism in SLE: above and beyond sex hormones
published pages: 3-10, ISSN: 0961-2033, DOI: 10.1177/0961203318815768
Lupus 28/1 2019-02-25
2018 Eleni Frangou, Akrivi Chrysanthopoulou, Alexandros Mitsios, Konstantinos Kambas, Stella Arelaki, Iliana Angelidou, Athanasios Arampatzioglou, Hariklia Gakiopoulou, George K Bertsias, Panayotis Verginis, Konstantinos Ritis, Dimitrios T Boumpas
REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)
published pages: annrheumdis-2018, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-213181
Annals of the Rheumatic Diseases 2019-02-25

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