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LUPUSCARE SIGNED

PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

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EC-Contrib. €

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 LUPUSCARE project word cloud

Explore the words cloud of the LUPUSCARE project. It provides you a very rough idea of what is the project "LUPUSCARE" about.

trios    originate    phenotypes    editing    epigenomic    abnormalities    constituents    150    elaborate    fundamental    genomic    ask    foundations    sle    self    characterization    interplay    unifying    correlation    bone    pathogenesis    data    innovative    biology    clinical    glimpse    technologies    expression    trial    hypothesis    initial    genomics    trait    somatic    cells    erythematosus    participate    laid    record    device    predominance    gender    chip    recognizes    lupus    homeostasis    hyperactivity    insights    rna    molecular    integrate    hscs    diagnosis    organ    taxonomy    therapy    tissue    severity    risk    therapeutic    systematic    questions    whereby    networks    profile    staggering    mechanism    diverse    perturbation    stem    environmental    female    allowed    elucidated    paradigm    varying    mutations    epigenetic    shift    matrices    extends    genetic    track    disease    cell    maintains    utility    family    culminating    microbiota    lie    combination    systemic    biological    gene    marrow    patients    diagnostics    genome    examine    pursuing    heterogeneous    trials    hematopoietic    humanized    panels    immunotherapy    monitoring    experimental    pathogenetic    models    boundaries    validate    single    throughput    autoimmunity    impacts    animal    lymphoma    personalized    immune    omics    sequencing   

Project "LUPUSCARE" data sheet

The following table provides information about the project.

Coordinator
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON 

Organization address
address: SORANOU EFESIOU 4
city: ATHINA
postcode: 115 27
website: www.bioacademy.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 2˙355˙000 €
 EC max contribution 2˙355˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) coordinator 2˙355˙000.00

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 Project objective

Systemic lupus erythematosus (SLE) is a heterogeneous disease whereby an interplay of environmental, genetic and epigenetic factors lead to perturbation of complex biological networks culminating into diverse clinical phenotypes of varying severity. High throughput methods have allowed an “initial glimpse” into pathogenesis and have laid the foundations for a molecular-based taxonomy for personalized therapy. Based on our experience with the molecular characterization of SLE, a recently completed RNA sequencing analysis of 150 patients, and our track- record of “paradigm shift” trials in SLE, we will integrate data from multi-tissue analyses with novel technologies to improve its diagnosis, monitoring and therapy, and ask fundamental pathogenetic questions in systemic autoimmunity. More specifically, we will design gene expression panels and “expression profile”/”clinical trait” correlation matrices for diagnostics, personalized immunotherapy and improved clinical trial design. In a systematic multi-tissue approach, we will examine the role of somatic mutations in enhancing immune hyperactivity and the risk for lymphoma. The staggering (7-9:1) female predominance will be elucidated through elaborate genomic, epigenomic and microbiota analyses of family trios. Finally, we will be pursuing the innovative hypothesis that the fundamental abnormalities of SLE lie within the bone marrow hematopoietic stem cells (HSCs) - from which all cells that participate in the pathogenesis of SLE originate - and establish it as a unifying pathogenetic mechanism. By a combination of novel experimental analyses with single cell genomics, multi–omics, humanized animal models, genome editing and an “organ on-a-chip” device, we will validate HSCs as a therapeutic target. The utility of SLE research extends beyond its boundaries, by providing unique insights as to how the immune system recognizes self-constituents and maintains its homeostasis, and how gender impacts on disease biology.

 Publications

year authors and title journal last update
List of publications.
2019 Grigoriou Maria
RNA-sequencing and transcriptome analysis of hematopoietic stem cells in systemic lupus erythematosus
published pages: , ISSN: , DOI:
2020-04-24
2019 Nikolaos I Panousis, George K Bertsias, Halit Ongen, Irini Gergianaki, Maria G Tektonidou, Maria Trachana, Luciana Romano-Palumbo, Deborah Bielser, Cedric Howald, Cristina Pamfil, Antonis Fanouriakis, Despoina Kosmara, Argyro Repa, Prodromos Sidiropoulos, Emmanouil T Dermitzakis, Dimitrios T Boumpas
Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity
published pages: 1079-1089, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-214379
Annals of the Rheumatic Diseases 78/8 2020-04-15
2020 D Nikolopoulos, M Kostopoulou, A Pieta, T Karageorgas, D Tseronis, K Chavatza, S Flouda, P Rapsomaniki, A Banos, E Kremasmenou, V Tzavara, P Katsimbri, A Fanouriakis, D T Boumpas
Evolving phenotype of systemic lupus erythematosus in Caucasians: low incidence of lupus nephritis, high burden of neuropsychiatric disease and increased rates of late-onset lupus in the ‘Attikon’ cohort
published pages: 96120332090893, ISSN: 0961-2033, DOI: 10.1177/0961203320908932
Lupus 2020-03-11
2019 Maria Grigoriou, Aggelos Banos, Anastasia Filia, Pavlos Pavlidis, Stavroula Giannouli, Vassiliki Karali, Dionysis Nikolopoulos, Antigone Pieta, George Bertsias, Panayotis Verginis, Ioannis Mitroulis, Dimitrios T Boumpas
Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus
published pages: annrheumdis-2019, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2019-215782
Annals of the Rheumatic Diseases 2020-01-30
2018 Katerina Gkirtzimanaki, Eleni Kabrani, Dimitra Nikoleri, Alexander Polyzos, Athanasios Blanas, Prodromos Sidiropoulos, Antonis Makrigiannakis, George Bertsias, Dimitrios T. Boumpas, Panayotis Verginis
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion
published pages: 921-933.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.001
Cell Reports 25/4 2019-04-16
2018 E.A.A. Christou, A. Banos, D. Kosmara, GK Bertsias, DT Boumpas
Sexual dimorphism in SLE: above and beyond sex hormones
published pages: 3-10, ISSN: 0961-2033, DOI: 10.1177/0961203318815768
Lupus 28/1 2019-02-25
2018 Eleni Frangou, Akrivi Chrysanthopoulou, Alexandros Mitsios, Konstantinos Kambas, Stella Arelaki, Iliana Angelidou, Athanasios Arampatzioglou, Hariklia Gakiopoulou, George K Bertsias, Panayotis Verginis, Konstantinos Ritis, Dimitrios T Boumpas
REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)
published pages: annrheumdis-2018, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-213181
Annals of the Rheumatic Diseases 2019-02-25

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