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Total Cost €


EC-Contrib. €






 LUPUSCARE project word cloud

Explore the words cloud of the LUPUSCARE project. It provides you a very rough idea of what is the project "LUPUSCARE" about.

therapeutic    sle    originate    models    severity    molecular    therapy    personalized    laid    utility    validate    organ    phenotypes    microbiota    glimpse    whereby    device    maintains    systematic    hematopoietic    lupus    track    mechanism    ask    trial    predominance    biology    innovative    editing    family    somatic    humanized    150    omics    boundaries    matrices    examine    abnormalities    stem    pursuing    pathogenetic    combination    taxonomy    biological    cells    record    immune    homeostasis    epigenetic    constituents    rna    trials    autoimmunity    clinical    paradigm    hypothesis    genomics    lie    allowed    varying    disease    hscs    integrate    heterogeneous    insights    gender    marrow    technologies    cell    profile    sequencing    erythematosus    expression    recognizes    gene    female    mutations    patients    hyperactivity    diagnostics    tissue    elaborate    pathogenesis    initial    questions    bone    animal    epigenomic    perturbation    shift    throughput    genomic    self    interplay    participate    characterization    culminating    monitoring    chip    fundamental    environmental    trait    risk    trios    staggering    elucidated    extends    genome    genetic    foundations    panels    correlation    single    systemic    unifying    impacts    immunotherapy    lymphoma    experimental    diagnosis    networks    diverse    data   

Project "LUPUSCARE" data sheet

The following table provides information about the project.


Organization address
city: ATHINA
postcode: 115 27

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 2˙355˙000 €
 EC max contribution 2˙355˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Systemic lupus erythematosus (SLE) is a heterogeneous disease whereby an interplay of environmental, genetic and epigenetic factors lead to perturbation of complex biological networks culminating into diverse clinical phenotypes of varying severity. High throughput methods have allowed an “initial glimpse” into pathogenesis and have laid the foundations for a molecular-based taxonomy for personalized therapy. Based on our experience with the molecular characterization of SLE, a recently completed RNA sequencing analysis of 150 patients, and our track- record of “paradigm shift” trials in SLE, we will integrate data from multi-tissue analyses with novel technologies to improve its diagnosis, monitoring and therapy, and ask fundamental pathogenetic questions in systemic autoimmunity. More specifically, we will design gene expression panels and “expression profile”/”clinical trait” correlation matrices for diagnostics, personalized immunotherapy and improved clinical trial design. In a systematic multi-tissue approach, we will examine the role of somatic mutations in enhancing immune hyperactivity and the risk for lymphoma. The staggering (7-9:1) female predominance will be elucidated through elaborate genomic, epigenomic and microbiota analyses of family trios. Finally, we will be pursuing the innovative hypothesis that the fundamental abnormalities of SLE lie within the bone marrow hematopoietic stem cells (HSCs) - from which all cells that participate in the pathogenesis of SLE originate - and establish it as a unifying pathogenetic mechanism. By a combination of novel experimental analyses with single cell genomics, multi–omics, humanized animal models, genome editing and an “organ on-a-chip” device, we will validate HSCs as a therapeutic target. The utility of SLE research extends beyond its boundaries, by providing unique insights as to how the immune system recognizes self-constituents and maintains its homeostasis, and how gender impacts on disease biology.


year authors and title journal last update
List of publications.
2019 Grigoriou Maria
RNA-sequencing and transcriptome analysis of hematopoietic stem cells in systemic lupus erythematosus
published pages: , ISSN: , DOI:
2019 Nikolaos I Panousis, George K Bertsias, Halit Ongen, Irini Gergianaki, Maria G Tektonidou, Maria Trachana, Luciana Romano-Palumbo, Deborah Bielser, Cedric Howald, Cristina Pamfil, Antonis Fanouriakis, Despoina Kosmara, Argyro Repa, Prodromos Sidiropoulos, Emmanouil T Dermitzakis, Dimitrios T Boumpas
Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity
published pages: 1079-1089, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-214379
Annals of the Rheumatic Diseases 78/8 2020-04-15
2020 D Nikolopoulos, M Kostopoulou, A Pieta, T Karageorgas, D Tseronis, K Chavatza, S Flouda, P Rapsomaniki, A Banos, E Kremasmenou, V Tzavara, P Katsimbri, A Fanouriakis, D T Boumpas
Evolving phenotype of systemic lupus erythematosus in Caucasians: low incidence of lupus nephritis, high burden of neuropsychiatric disease and increased rates of late-onset lupus in the ‘Attikon’ cohort
published pages: 96120332090893, ISSN: 0961-2033, DOI: 10.1177/0961203320908932
Lupus 2020-03-11
2019 Maria Grigoriou, Aggelos Banos, Anastasia Filia, Pavlos Pavlidis, Stavroula Giannouli, Vassiliki Karali, Dionysis Nikolopoulos, Antigone Pieta, George Bertsias, Panayotis Verginis, Ioannis Mitroulis, Dimitrios T Boumpas
Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus
published pages: annrheumdis-2019, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2019-215782
Annals of the Rheumatic Diseases 2020-01-30
2018 Katerina Gkirtzimanaki, Eleni Kabrani, Dimitra Nikoleri, Alexander Polyzos, Athanasios Blanas, Prodromos Sidiropoulos, Antonis Makrigiannakis, George Bertsias, Dimitrios T. Boumpas, Panayotis Verginis
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion
published pages: 921-933.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.001
Cell Reports 25/4 2019-04-16
2018 E.A.A. Christou, A. Banos, D. Kosmara, GK Bertsias, DT Boumpas
Sexual dimorphism in SLE: above and beyond sex hormones
published pages: 3-10, ISSN: 0961-2033, DOI: 10.1177/0961203318815768
Lupus 28/1 2019-02-25
2018 Eleni Frangou, Akrivi Chrysanthopoulou, Alexandros Mitsios, Konstantinos Kambas, Stella Arelaki, Iliana Angelidou, Athanasios Arampatzioglou, Hariklia Gakiopoulou, George K Bertsias, Panayotis Verginis, Konstantinos Ritis, Dimitrios T Boumpas
REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)
published pages: annrheumdis-2018, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-213181
Annals of the Rheumatic Diseases 2019-02-25

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