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UPRECON SIGNED

Ultrafast photonics for the detection and recognition of toxic spine-structures of amyloid aggregates linked to neurodegenerative disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 UPRECON project word cloud

Explore the words cloud of the UPRECON project. It provides you a very rough idea of what is the project "UPRECON" about.

forms    amyloid    ancillary    reduces    region    modality    skills    spectroscopy    diseases    transfer    doctoral    science    combination    suspected    worsening    chemical    designed    intermediates    regarding    form    acute    irradiation    time    safe    aggregates    person    cells    fibril    intensity    training    society    supplementary    biophotonics    structural    potentially    fibrils    polish    tissues    symptoms    me    architectures    proteins    patients    health    disease    infrared    diagnosed    resolved    human    inhibition    parkinson    academy    surgical    persons    building    intervention    brains    invasive    newly    indicate    aged    projections    diagnosis    laboratory    strategy    detect    clear    host    career    2050    curing    toxic    expertise    methodology    cognition    enormous    light    damage    peptides    setups    oligomeric    absorption    ultrafast    multiphoton    diagnose    alzheimer    labels    post    laser    detection    technique    benefits    85    pathogenic   

Project "UPRECON" data sheet

The following table provides information about the project.

Coordinator
UNIWERSYTET WARSZAWSKI 

Organization address
address: KRAKOWSKIE PRZEDMIESCIE 26/28
city: WARSZAWA
postcode: 00 927
website: www.uw.edu.pl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Poland [PL]
 Total cost 134˙462 €
 EC max contribution 134˙462 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIWERSYTET WARSZAWSKI PL (WARSZAWA) coordinator 134˙462.00
2    INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK PL (WARSZAWA) participant 0.00

Map

 Project objective

Projections indicate that, by 2050, every person aged 85 years or more will be diagnosed with a cognition-related disease. While there is currently no clear strategy for curing such diseases, there are promising developments in the early diagnosis of disease and the inhibition of worsening symptoms. Building on results obtained during my post-doctoral work regarding laser technology for amyloid aggregates detection, I propose to use an advanced ultrafast spectroscopy for structural analyses of the peptides and proteins that form the different fibril architectures in the brains of patients with pathogenic aggregates. In combination with multiphoton absorption, this laser technique has the potential to detect and diagnose in a non-invasive modality the early forms of toxic oligomeric intermediates in the brains of persons with suspected Alzheimer´s or Parkinson´s disease. This methodology has potentially enormous benefits for patients and society. Importantly, the proposed approach of using high-intensity light in the infrared region of absorption does not damage cells and tissues during long-duration irradiation, it does not require the use of chemical labels, and it reduces the need for surgical intervention, as it is non-invasive and safe for human health. I will transfer the knowledge and expertise on biophotonics of amyloid fibrils to Europe and the Host laboratory at the Polish Academy of Science will provide me with advanced training in time-resolved ultrafast laser spectroscopy and access to newly designed setups, as well as supplementary career path-specific training in ancillary skills.

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The information about "UPRECON" are provided by the European Opendata Portal: CORDIS opendata.

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