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Redirecting glial progenitor fate to rebuild the injured Brain

Total Cost €


EC-Contrib. €






 REBUILDCNS project word cloud

Explore the words cloud of the REBUILDCNS project. It provides you a very rough idea of what is the project "REBUILDCNS" about.

brain    leverage    translational    na    injury    glial    excitingly    signature    function    edge    combining    identity    biology    direct    data    regenerating    establishing    fundamental    ve    treating    platforms    preliminary    drives    shown    diversity    becomes    re    zebrafish    functional    tracing    enhancer    million    generation    few    validated    governing    envisage    activation    led    editing    models    clonal    technological    dormant    endogenous    iuml    billions    competence    manipulation    regenerative    connections    genomics    combined    landscape    transcriptional    cutting    transcription    too    indicates    activates    ways    underlie    progenitors    experimental    protocols    impacts    follow    over    omics    generate    lab    restricted    despite    demethylation    directed    modulation    fate    lines    types    choices    chromatin    cns    developmental    breakthroughs    genetics    attempt    underlying    progenitor    exit    multidisciplinary    embryonic    missing    rodents    leads    cell    genome    discoveries    mechanisms    epigenome    inflammatory    lineage    single    damaged    cellular    injured    mouse    rules    decisions    repair    transcriptome    disorder    enhancers    adult    environment   

Project "REBUILDCNS" data sheet

The following table provides information about the project.


Organization address
postcode: 69120

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Over a million different cell types and billions of connections underlie brain function. While the embryonic brain glial progenitors generate this cellular diversity, in the adult brain progenitor competence becomes restricted to generation of few cell types. Thus, any attempt to repair the brain requires knowledge of the rules governing fate decisions within a damaged environment. We have shown that injury activates an inflammatory transcriptional signature in glial progenitors leading to exit from a dormant state. Excitingly, our recent data indicates that injury leads to demethylation of developmental enhancers in these glial progenitors too. In the regenerating zebrafish, activation of enhancers drives a transcriptional regenerative program. Yet, in rodents, despite enhancer demethylation by injury, transcription of a developmental program is missing. The overall goal of this project is to envisage ways to efficiently commission enhancers to re-direct lineage choices of glial progenitors towards re-establishing brain function following injury. Recent technological breakthroughs, including clonal lineage tracing, genome editing, and single cell “omics” combined with mouse genetics and injury models will allow (i) analysis of fate choices in the naïve and injured CNS (ii) study of how the chromatin landscape impacts transcriptional modulation of cell identity (iii) to finally design an integrated manipulation of the epigenome, transcriptome and environment for directed brain repair by endogenous progenitors. We follow a multidisciplinary approach combining cutting edge technology in functional genomics, developmental biology and translational research and leverage on a set of cutting-edge experimental platforms established in my lab and validated protocols that have led to exciting preliminary discoveries. We will provide fundamental knowledge on the mechanisms underlying lineage-decisions of CNS progenitors and open new research lines for treating CNS disorder.


year authors and title journal last update
List of publications.
2019 Gülce S. Gülcüler Balta, Cornelia Monzel, Susanne Kleber, Joel Beaudouin, Emre Balta, Thomas Kaindl, Si Chen, Liang Gao, Meinolf Thiemann, Christian R. Wirtz, Yvonne Samstag, Motomu Tanaka, Ana Martin-Villalba
3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival
published pages: 2295-2306.e6, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.10.054
Cell Reports 29/8 2020-02-06
2019 Avni Baser, Maxim Skabkin, Susanne Kleber, Yonglong Dang, Gülce S. Gülcüler Balta, Georgios Kalamakis, Manuel Göpferich, Damian Carvajal Ibañez, Roman Schefzik, Alejandro Santos Lopez, Enric Llorens Bobadilla, Carsten Schultz, Bernd Fischer, Ana Martin-Villalba
Onset of differentiation is post-transcriptionally controlled in adult neural stem cells
published pages: 100-104, ISSN: 0028-0836, DOI: 10.1038/s41586-019-0888-x
Nature 566/7742 2020-02-06
2019 Georgios Kalamakis, Daniel Brüne, Srikanth Ravichandran, Jan Bolz, Wenqiang Fan, Frederik Ziebell, Thomas Stiehl, Francisco Catalá-Martinez, Janina Kupke, Sheng Zhao, Enric Llorens-Bobadilla, Katharina Bauer, Stefanie Limpert, Birgit Berger, Urs Christen, Peter Schmezer, Jan Philipp Mallm, Benedikt Berninger, Simon Anders, Antonio del Sol, Anna Marciniak-Czochra, Ana Martin-Villalba
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
published pages: 1407-1419.e14, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.01.040
Cell 176/6 2020-02-06

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