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HOPE SIGNED

HOminin Proteomes in human Evolution

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "HOPE" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

This project aims to reconstruct the genetic relationships between our and extinct hominin species from sites and time periods incompatible with ancient DNA preservation through mass-spectrometry based sequencing of ancient hominin proteins. Understanding the evolutionary relationships between extinct and extant hominins is a major goal of palaeoanthropology, including insights into population dynamics and traits selected for/against in particular hominin lineages. Up to recently this was exclusively achieved through ancient DNA analysis. Ancient DNA survives for a limited amount of time, however, and is commonly degraded entirely after 0.5 or 1.0 Ma. A new biomolecular approach to this issue is the analysis of ancient proteins preserved in enamel, dentine and bone from hominin fossils, as recent studies demonstrate that ancient proteins survive for longer stretches of time than DNA. HOPE will advance these developments by applying novel methodological approaches to the extraction and characterization of hominin ancient proteins in samples beyond the survival of ancient DNA. Specific objectives are 1) to test proposed evolutionary hypotheses on hominin evolution through the characterization of ancient enamel protein sequences from a number of extinct hominin populations of significant age, 2) to increase non-collagenous protein sequence recovery from dentine samples, 3) to explore the population proteomic potential of hominin proteomes, and 4) to understand changes in enamel proteome composition throughout hominid evolution. These objectives will be realized by analysing hominin specimens from a range of taxonomic clades present in the Early, Middle and Late Pleistocene of Africa and Eurasia. HOPE thereby provides novel interdisciplinary insights into human evolution and methodological tools of use across palaeonthropology and evolutionary biology.

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The information about "HOPE" are provided by the European Opendata Portal: CORDIS opendata.

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