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ChromaSTORM SIGNED

Visualising how proteins fold DNA into topologically associating domains in single human cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ChromaSTORM project word cloud

Explore the words cloud of the ChromaSTORM project. It provides you a very rough idea of what is the project "ChromaSTORM" about.

cell    description    human    replication    copy    structures    enigmatic    imaging    nucleosome    topologically    revealed    largely    prerequisite    domains    architectural    principles    size    variations    functional    structuring    chromatin    dynamics    functions    information    resolution    absolute    tads    multidisciplinary    reveal    quantitative    mediator    nucleosomes    building    blocks    visualise    integrating    microscopy    how    manner    modulated    first    corresponds    structure    genome    organisers    function    tad    organisation    spatial    architecture    super    data    associating    regulates    simultaneously    core    nm    context    inner    hierarchical    few    genomic    carry    depletion    model    fundamental    understand    protein    genetic    individual    despite    advent    cohesin    emerge    backbone    ligation    3d    employ    condensin    decade    repair    cells    inside    tools    phenotypic    proteins    last    ctcf    transcription    additionally    situ    vital    proximity    derive    acute    dna   

Project "ChromaSTORM" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 174˙806.00

Map

 Project objective

How can phenotypic variations emerge from cells that carry the same genetic information? It is one of today’s great challenges to understand how genetic information is modulated inside the cell. Over the last decade, insight from genome-wide proximity-based ligation approaches revealed that the genome is organised in a hierarchical manner with the help of structuring proteins, and that this spatial organisation regulates the core functions of the genome, such as transcription, replication and repair. In this context, topologically associating domains (TADs) were identified as fundamental and functional building blocks of chromatin organisation above the nucleosome level. Despite its vital importance, our current understanding of the spatial organisation of TADs remains largely enigmatic. With the advent of super-resolution microscopy, tools are now available for studying genomic structures and their functional dynamics in situ at a resolution of 10 nm which corresponds to the size of a few nucleosomes. The goal of this project is to reveal the principles of TAD organisation in human cells. To achieve this, I will employ a multidisciplinary imaging-based approach. I will simultaneously visualise the DNA backbone of TADs and architectural proteins involved in TAD structure applying 3D super-resolution microscopy. I will focus on the key TAD organisers CTCF and Cohesin, as well as on Mediator and Condensin II. Additionally, I will directly study their individual structuring function for TADs by their acute depletion. Integrating these data with quantitative measurements of absolute protein copy numbers, I will derive a data-driven model of inner TAD organisation in cells. These studies will provide the first 3D description of this fundamental chromatin super-structure and will further our understanding of genome architecture which is a prerequisite for understanding genome function.

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The information about "CHROMASTORM" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-14 13:08:12) correctly updated