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SYGMA SIGNED

Synthetic photobiology for light controllable active matter

Total Cost €

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EC-Contrib. €

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Partnership

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 SYGMA project word cloud

Explore the words cloud of the SYGMA project. It provides you a very rough idea of what is the project "SYGMA" about.

biologists    from    particle    death    optical    modular    employ    shape    rates    drive    assembling    formidable    propelled    body    microcolonies    temporal    biology    basic    environment    quantitative    differently    photoreceptors    uniform    speed    active    soft    tumbling    cellular    functions    morphogenesis    building    counterpart    reconfigurable    first    engineer    mechanics    experiments    interactively    suspended    forces    genetic    shaping    pressure    wire    blocks    tools    colonies    questions    force    statistical    toolkit    engineering    motility    biohybrid    sense    triumphs    branch    experimentally    illumination    customized    answers    sygma    breaking    unprecedented    programs    dynamical    parts    micro    signals    light    materials    fundamental    machines    self    living    synthetic    computing    bacteria    external    microstructures    physical    standpoint    mold    molecular    microcars    rgb    greatest    cargos    machinery    bacterial    contains    cell    density    atoms    structured    particles    spatio    bath    theory    transport    validated    fast    modulations    tunable    transmembrane    colloidal    biological    swarms    swimming    physics    colloids    replicate    protocols    contemporary    compute   

Project "SYGMA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA 

Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185
website: www.uniroma1.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙397˙500 €
 EC max contribution 2˙397˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) coordinator 1˙018˙750.00
2    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 710˙000.00
3    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 668˙750.00

Map

 Project objective

From a Physics and Engineering standpoint, swimming bacteria are a formidable example of self-propelled micro-machines. Together with their synthetic counterpart, self-propelled colloids, they represent the “living” atoms of active matter, an exciting branch of contemporary soft matter and statistical mechanics. Differently from synthetic colloids, however, each bacterial cell contains all the molecular machinery that is required to self-replicate, sense the environment, process information and compute responses. Breaking down these biological functions into basic genetic parts has been one of the greatest triumphs of molecular biology. Today, synthetic biologists are assembling these parts into new genetic programs and exploiting bacteria as computing micro-machines. Project SYGMA will employ the synthetic biology toolkit to provide the building blocks for a light controllable active matter having reliable, reconfigurable and interactively tunable dynamical properties. We will first engineer transmembrane photoreceptors to wire RGB external light signals to cellular physical responses like speed, tumbling, growth and death rates. These genetic parts will allow the modular design of customized active particles to build active materials with unprecedented optical control capabilities. Using these new tools we will address, with experiments and theory, fundamental questions like: how fast can we drive particle density using spatio-temporal motility modulations? what is the force on a body suspended in a bath of bacteria with non uniform motility? how do physical forces contribute to morphogenesis in bacterial colonies? Finding quantitative and experimentally validated answers will eventually allow us to engineer structured illumination protocols to mold living microstructures, transport colloidal cargos by shaping active pressure, control swarms of biohybrid microcars and shape bacterial microcolonies.

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The information about "SYGMA" are provided by the European Opendata Portal: CORDIS opendata.

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