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SYGMA SIGNED

Synthetic photobiology for light controllable active matter

Total Cost €

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EC-Contrib. €

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Partnership

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 SYGMA project word cloud

Explore the words cloud of the SYGMA project. It provides you a very rough idea of what is the project "SYGMA" about.

breaking    contemporary    differently    fundamental    cellular    colloids    force    protocols    light    biohybrid    microcolonies    greatest    synthetic    modular    blocks    experiments    biologists    environment    first    morphogenesis    speed    optical    particle    standpoint    structured    colonies    computing    engineer    compute    answers    basic    cargos    questions    triumphs    bacterial    biology    functions    parts    spatio    mechanics    biological    counterpart    microcars    dynamical    engineering    rgb    colloidal    illumination    customized    materials    formidable    tools    microstructures    interactively    propelled    photoreceptors    sense    validated    swimming    atoms    cell    statistical    fast    machines    building    temporal    theory    living    motility    shape    bath    transmembrane    suspended    unprecedented    quantitative    from    pressure    tumbling    reconfigurable    death    toolkit    machinery    micro    replicate    swarms    body    particles    transport    contains    uniform    assembling    self    mold    tunable    drive    molecular    genetic    wire    branch    density    forces    soft    experimentally    shaping    bacteria    physics    signals    sygma    physical    active    rates    modulations    programs    employ    external   

Project "SYGMA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA 

Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185
website: www.uniroma1.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙397˙500 €
 EC max contribution 2˙397˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) coordinator 1˙018˙750.00
2    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 710˙000.00
3    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 668˙750.00

Map

 Project objective

From a Physics and Engineering standpoint, swimming bacteria are a formidable example of self-propelled micro-machines. Together with their synthetic counterpart, self-propelled colloids, they represent the “living” atoms of active matter, an exciting branch of contemporary soft matter and statistical mechanics. Differently from synthetic colloids, however, each bacterial cell contains all the molecular machinery that is required to self-replicate, sense the environment, process information and compute responses. Breaking down these biological functions into basic genetic parts has been one of the greatest triumphs of molecular biology. Today, synthetic biologists are assembling these parts into new genetic programs and exploiting bacteria as computing micro-machines. Project SYGMA will employ the synthetic biology toolkit to provide the building blocks for a light controllable active matter having reliable, reconfigurable and interactively tunable dynamical properties. We will first engineer transmembrane photoreceptors to wire RGB external light signals to cellular physical responses like speed, tumbling, growth and death rates. These genetic parts will allow the modular design of customized active particles to build active materials with unprecedented optical control capabilities. Using these new tools we will address, with experiments and theory, fundamental questions like: how fast can we drive particle density using spatio-temporal motility modulations? what is the force on a body suspended in a bath of bacteria with non uniform motility? how do physical forces contribute to morphogenesis in bacterial colonies? Finding quantitative and experimentally validated answers will eventually allow us to engineer structured illumination protocols to mold living microstructures, transport colloidal cargos by shaping active pressure, control swarms of biohybrid microcars and shape bacterial microcolonies.

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The information about "SYGMA" are provided by the European Opendata Portal: CORDIS opendata.

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