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SYGMA SIGNED

Synthetic photobiology for light controllable active matter

Total Cost €

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EC-Contrib. €

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Partnership

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 SYGMA project word cloud

Explore the words cloud of the SYGMA project. It provides you a very rough idea of what is the project "SYGMA" about.

body    physical    signals    biology    swimming    experimentally    modulations    tumbling    engineering    optical    motility    programs    assembling    colloidal    tools    light    environment    drive    forces    microcars    particle    micro    basic    statistical    contains    biohybrid    density    parts    branch    cellular    blocks    microstructures    rates    rgb    spatio    biological    propelled    shaping    machinery    swarms    bath    structured    machines    computing    materials    validated    death    genetic    experiments    mechanics    replicate    temporal    bacteria    reconfigurable    colonies    customized    pressure    sygma    first    transport    engineer    biologists    self    photoreceptors    fundamental    suspended    tunable    wire    microcolonies    living    employ    counterpart    dynamical    standpoint    fast    external    active    cell    compute    atoms    breaking    synthetic    modular    triumphs    toolkit    cargos    morphogenesis    contemporary    molecular    shape    mold    functions    questions    protocols    quantitative    greatest    unprecedented    from    formidable    bacterial    sense    differently    uniform    interactively    answers    colloids    force    illumination    theory    speed    transmembrane    physics    building    soft    particles   

Project "SYGMA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA 

Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185
website: www.uniroma1.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙397˙500 €
 EC max contribution 2˙397˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) coordinator 1˙018˙750.00
2    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 710˙000.00
3    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 668˙750.00

Map

 Project objective

From a Physics and Engineering standpoint, swimming bacteria are a formidable example of self-propelled micro-machines. Together with their synthetic counterpart, self-propelled colloids, they represent the “living” atoms of active matter, an exciting branch of contemporary soft matter and statistical mechanics. Differently from synthetic colloids, however, each bacterial cell contains all the molecular machinery that is required to self-replicate, sense the environment, process information and compute responses. Breaking down these biological functions into basic genetic parts has been one of the greatest triumphs of molecular biology. Today, synthetic biologists are assembling these parts into new genetic programs and exploiting bacteria as computing micro-machines. Project SYGMA will employ the synthetic biology toolkit to provide the building blocks for a light controllable active matter having reliable, reconfigurable and interactively tunable dynamical properties. We will first engineer transmembrane photoreceptors to wire RGB external light signals to cellular physical responses like speed, tumbling, growth and death rates. These genetic parts will allow the modular design of customized active particles to build active materials with unprecedented optical control capabilities. Using these new tools we will address, with experiments and theory, fundamental questions like: how fast can we drive particle density using spatio-temporal motility modulations? what is the force on a body suspended in a bath of bacteria with non uniform motility? how do physical forces contribute to morphogenesis in bacterial colonies? Finding quantitative and experimentally validated answers will eventually allow us to engineer structured illumination protocols to mold living microstructures, transport colloidal cargos by shaping active pressure, control swarms of biohybrid microcars and shape bacterial microcolonies.

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The information about "SYGMA" are provided by the European Opendata Portal: CORDIS opendata.

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