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SYGMA SIGNED

Synthetic photobiology for light controllable active matter

Total Cost €

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EC-Contrib. €

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Partnership

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 SYGMA project word cloud

Explore the words cloud of the SYGMA project. It provides you a very rough idea of what is the project "SYGMA" about.

customized    particle    bacteria    breaking    microstructures    death    replicate    formidable    atoms    particles    active    structured    transport    reconfigurable    biology    optical    illumination    first    signals    cell    programs    tools    swimming    protocols    swarms    physical    colloidal    environment    statistical    assembling    cellular    sense    drive    answers    uniform    tunable    speed    spatio    soft    biological    living    sygma    mold    building    contains    bacterial    rates    materials    dynamical    physics    suspended    computing    questions    photoreceptors    cargos    contemporary    blocks    molecular    tumbling    standpoint    fundamental    forces    transmembrane    force    engineer    unprecedented    theory    interactively    engineering    colonies    density    temporal    genetic    body    compute    greatest    morphogenesis    experimentally    branch    machinery    basic    shape    microcars    machines    mechanics    toolkit    external    motility    counterpart    microcolonies    modulations    self    colloids    propelled    synthetic    functions    differently    rgb    triumphs    light    wire    from    employ    bath    parts    validated    quantitative    shaping    pressure    experiments    biologists    fast    micro    modular    biohybrid   

Project "SYGMA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA 

Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185
website: www.uniroma1.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙397˙500 €
 EC max contribution 2˙397˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) coordinator 1˙018˙750.00
2    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 710˙000.00
3    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 668˙750.00

Map

 Project objective

From a Physics and Engineering standpoint, swimming bacteria are a formidable example of self-propelled micro-machines. Together with their synthetic counterpart, self-propelled colloids, they represent the “living” atoms of active matter, an exciting branch of contemporary soft matter and statistical mechanics. Differently from synthetic colloids, however, each bacterial cell contains all the molecular machinery that is required to self-replicate, sense the environment, process information and compute responses. Breaking down these biological functions into basic genetic parts has been one of the greatest triumphs of molecular biology. Today, synthetic biologists are assembling these parts into new genetic programs and exploiting bacteria as computing micro-machines. Project SYGMA will employ the synthetic biology toolkit to provide the building blocks for a light controllable active matter having reliable, reconfigurable and interactively tunable dynamical properties. We will first engineer transmembrane photoreceptors to wire RGB external light signals to cellular physical responses like speed, tumbling, growth and death rates. These genetic parts will allow the modular design of customized active particles to build active materials with unprecedented optical control capabilities. Using these new tools we will address, with experiments and theory, fundamental questions like: how fast can we drive particle density using spatio-temporal motility modulations? what is the force on a body suspended in a bath of bacteria with non uniform motility? how do physical forces contribute to morphogenesis in bacterial colonies? Finding quantitative and experimentally validated answers will eventually allow us to engineer structured illumination protocols to mold living microstructures, transport colloidal cargos by shaping active pressure, control swarms of biohybrid microcars and shape bacterial microcolonies.

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The information about "SYGMA" are provided by the European Opendata Portal: CORDIS opendata.

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