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EARLYDETECT SIGNED

Development of an accurate, early diagnostic tool for ovarian cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EARLYDETECT project word cloud

Explore the words cloud of the EARLYDETECT project. It provides you a very rough idea of what is the project "EARLYDETECT" about.

synthetic    patients    glycans    until    150    burden    setting    immunoassay    signal    recognition    translation    capitalizing    translated    throughput    diagnostic    subtle    receptors    every    ovarian    diagnosed    patent    tumours    118294    radically    sensitivity    differentiate    amplification    women    glycoproteins    sharply    offers    serum    alterations    first    structures    fluorescent    care    nanoparticles    platform    surface    swift    accurate    differences    secreted    unmet    rapid    molecularly    microplate    controls    tested    wo2015    glycosurf    standard    tools    imposed    serve    arrangement    lives    validating    reducing    variations    chains    reproducibility    minimally    suitable    lack    create    grant    discriminate    casted    selectivity    economic    worldwide    urgent    benign    time    samples    erc    identification    glycosylation    clinical    saving    glycan    assay    clinic    clinically    biomarkers    easily    detecting    stages    automatable    ultimately    spatial    assays    kills    invasive    fact    nanopockets    earlier    fit    readout    screening    consolidator    health    oc    cancer    social   

Project "EARLYDETECT" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 150˙000.00

Map

 Project objective

Every year, ovarian cancer (OC) kills more than 40 000 women in Europe and 150 000 worldwide. In large part this is due to the fact that most women are not diagnosed until advanced stages. There is an urgent unmet clinical need for screening tools for the early, accurate identification of OC. OC is associated with alterations in glycosylation of secreted glycoproteins, and as such, they can serve as early OC biomarkers. However, this knowledge has still not been translated into clinic due to the lack of assays that can differentiate subtle differences between glycan chains. For the first time, under the ERC consolidator grant-GLYCOSURF, we developed a synthetic glycan recognition platform that can sharply discriminate between different overall glycan structures (Patent No: WO2015/118294). Capitalizing on the knowledge of glycosylation variations in OC and our unique glycan recognition technology, we will be developing and clinically validating a new glycan-based test for detecting OC earlier and more effectively through a simple serum test. OC-associated glycans will be molecularly casted on fluorescent nanoparticles to create surface nanopockets with glycan receptors in a specific spatial arrangement to fit only OC-associated glycans. A microplate immunoassay with high sensitivity, selectivity and reproducibility will be developed, wherein the glycan-casted nanoparticles will provide a means for selectivity, signal amplification and fluorescent readout. Serum samples from OC patients and controls from women with benign tumours will be tested. The assay will be minimally-invasive, cost-effective and will be suitable for rapid, easily automatable, high-throughput screening, promoting swift translation into the clinical setting. This project offers therefore the potential to radically change the diagnostic standard of care for OC, ultimately saving lives and reducing the health, social and economic burden imposed by OC.

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The information about "EARLYDETECT" are provided by the European Opendata Portal: CORDIS opendata.

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