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EARLYDETECT SIGNED

Development of an accurate, early diagnostic tool for ovarian cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EARLYDETECT project word cloud

Explore the words cloud of the EARLYDETECT project. It provides you a very rough idea of what is the project "EARLYDETECT" about.

spatial    alterations    tested    stages    serve    setting    nanopockets    easily    platform    molecularly    suitable    readout    diagnostic    selectivity    automatable    signal    tumours    sensitivity    150    capitalizing    variations    sharply    casted    clinically    radically    diagnosed    erc    immunoassay    subtle    secreted    consolidator    clinic    minimally    economic    discriminate    patients    cancer    worldwide    grant    reducing    translation    women    fact    social    synthetic    earlier    unmet    serum    surface    assay    differences    validating    chains    fluorescent    amplification    receptors    create    nanoparticles    assays    glycosylation    swift    fit    wo2015    accurate    until    glycan    118294    oc    burden    saving    ultimately    microplate    patent    recognition    differentiate    glycoproteins    reproducibility    identification    screening    throughput    biomarkers    time    samples    health    controls    kills    structures    lack    urgent    first    ovarian    imposed    lives    clinical    tools    benign    rapid    care    glycosurf    every    standard    offers    invasive    translated    detecting    arrangement    glycans   

Project "EARLYDETECT" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 150˙000.00

Map

 Project objective

Every year, ovarian cancer (OC) kills more than 40 000 women in Europe and 150 000 worldwide. In large part this is due to the fact that most women are not diagnosed until advanced stages. There is an urgent unmet clinical need for screening tools for the early, accurate identification of OC. OC is associated with alterations in glycosylation of secreted glycoproteins, and as such, they can serve as early OC biomarkers. However, this knowledge has still not been translated into clinic due to the lack of assays that can differentiate subtle differences between glycan chains. For the first time, under the ERC consolidator grant-GLYCOSURF, we developed a synthetic glycan recognition platform that can sharply discriminate between different overall glycan structures (Patent No: WO2015/118294). Capitalizing on the knowledge of glycosylation variations in OC and our unique glycan recognition technology, we will be developing and clinically validating a new glycan-based test for detecting OC earlier and more effectively through a simple serum test. OC-associated glycans will be molecularly casted on fluorescent nanoparticles to create surface nanopockets with glycan receptors in a specific spatial arrangement to fit only OC-associated glycans. A microplate immunoassay with high sensitivity, selectivity and reproducibility will be developed, wherein the glycan-casted nanoparticles will provide a means for selectivity, signal amplification and fluorescent readout. Serum samples from OC patients and controls from women with benign tumours will be tested. The assay will be minimally-invasive, cost-effective and will be suitable for rapid, easily automatable, high-throughput screening, promoting swift translation into the clinical setting. This project offers therefore the potential to radically change the diagnostic standard of care for OC, ultimately saving lives and reducing the health, social and economic burden imposed by OC.

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The information about "EARLYDETECT" are provided by the European Opendata Portal: CORDIS opendata.

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