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EARLYDETECT SIGNED

Development of an accurate, early diagnostic tool for ovarian cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EARLYDETECT project word cloud

Explore the words cloud of the EARLYDETECT project. It provides you a very rough idea of what is the project "EARLYDETECT" about.

translation    earlier    standard    sharply    differences    fluorescent    lives    lack    controls    offers    stages    suitable    secreted    serve    microplate    capitalizing    sensitivity    variations    screening    synthetic    throughput    assay    fact    arrangement    signal    minimally    nanoparticles    amplification    clinical    burden    invasive    reducing    urgent    glycosurf    until    samples    erc    grant    tested    every    118294    reproducibility    ultimately    immunoassay    glycosylation    validating    economic    worldwide    nanopockets    biomarkers    differentiate    easily    time    platform    oc    readout    diagnostic    consolidator    saving    recognition    patent    translated    clinically    cancer    rapid    selectivity    imposed    automatable    assays    ovarian    tools    kills    molecularly    swift    spatial    care    social    diagnosed    wo2015    glycans    women    detecting    patients    chains    accurate    glycoproteins    identification    casted    create    serum    benign    surface    first    alterations    structures    tumours    150    subtle    health    unmet    fit    radically    discriminate    clinic    setting    receptors    glycan   

Project "EARLYDETECT" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 150˙000.00

Map

 Project objective

Every year, ovarian cancer (OC) kills more than 40 000 women in Europe and 150 000 worldwide. In large part this is due to the fact that most women are not diagnosed until advanced stages. There is an urgent unmet clinical need for screening tools for the early, accurate identification of OC. OC is associated with alterations in glycosylation of secreted glycoproteins, and as such, they can serve as early OC biomarkers. However, this knowledge has still not been translated into clinic due to the lack of assays that can differentiate subtle differences between glycan chains. For the first time, under the ERC consolidator grant-GLYCOSURF, we developed a synthetic glycan recognition platform that can sharply discriminate between different overall glycan structures (Patent No: WO2015/118294). Capitalizing on the knowledge of glycosylation variations in OC and our unique glycan recognition technology, we will be developing and clinically validating a new glycan-based test for detecting OC earlier and more effectively through a simple serum test. OC-associated glycans will be molecularly casted on fluorescent nanoparticles to create surface nanopockets with glycan receptors in a specific spatial arrangement to fit only OC-associated glycans. A microplate immunoassay with high sensitivity, selectivity and reproducibility will be developed, wherein the glycan-casted nanoparticles will provide a means for selectivity, signal amplification and fluorescent readout. Serum samples from OC patients and controls from women with benign tumours will be tested. The assay will be minimally-invasive, cost-effective and will be suitable for rapid, easily automatable, high-throughput screening, promoting swift translation into the clinical setting. This project offers therefore the potential to radically change the diagnostic standard of care for OC, ultimately saving lives and reducing the health, social and economic burden imposed by OC.

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The information about "EARLYDETECT" are provided by the European Opendata Portal: CORDIS opendata.

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