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EARLYDETECT SIGNED

Development of an accurate, early diagnostic tool for ovarian cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EARLYDETECT project word cloud

Explore the words cloud of the EARLYDETECT project. It provides you a very rough idea of what is the project "EARLYDETECT" about.

oc    differences    throughput    chains    burden    time    swift    selectivity    offers    kills    until    lives    readout    reducing    diagnosed    worldwide    translation    immunoassay    structures    nanoparticles    secreted    glycosurf    biomarkers    arrangement    cancer    clinically    serum    health    glycosylation    create    tumours    fluorescent    differentiate    synthetic    consolidator    radically    women    glycans    discriminate    setting    amplification    alterations    recognition    erc    tested    tools    every    glycoproteins    fit    rapid    saving    social    detecting    wo2015    variations    clinic    earlier    microplate    screening    patent    stages    nanopockets    glycan    surface    care    accurate    spatial    easily    casted    molecularly    urgent    diagnostic    signal    ultimately    first    grant    118294    suitable    clinical    unmet    assay    standard    benign    lack    subtle    validating    controls    economic    capitalizing    translated    fact    samples    assays    sharply    150    imposed    patients    serve    invasive    identification    platform    automatable    ovarian    reproducibility    sensitivity    receptors    minimally   

Project "EARLYDETECT" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 150˙000.00

Map

 Project objective

Every year, ovarian cancer (OC) kills more than 40 000 women in Europe and 150 000 worldwide. In large part this is due to the fact that most women are not diagnosed until advanced stages. There is an urgent unmet clinical need for screening tools for the early, accurate identification of OC. OC is associated with alterations in glycosylation of secreted glycoproteins, and as such, they can serve as early OC biomarkers. However, this knowledge has still not been translated into clinic due to the lack of assays that can differentiate subtle differences between glycan chains. For the first time, under the ERC consolidator grant-GLYCOSURF, we developed a synthetic glycan recognition platform that can sharply discriminate between different overall glycan structures (Patent No: WO2015/118294). Capitalizing on the knowledge of glycosylation variations in OC and our unique glycan recognition technology, we will be developing and clinically validating a new glycan-based test for detecting OC earlier and more effectively through a simple serum test. OC-associated glycans will be molecularly casted on fluorescent nanoparticles to create surface nanopockets with glycan receptors in a specific spatial arrangement to fit only OC-associated glycans. A microplate immunoassay with high sensitivity, selectivity and reproducibility will be developed, wherein the glycan-casted nanoparticles will provide a means for selectivity, signal amplification and fluorescent readout. Serum samples from OC patients and controls from women with benign tumours will be tested. The assay will be minimally-invasive, cost-effective and will be suitable for rapid, easily automatable, high-throughput screening, promoting swift translation into the clinical setting. This project offers therefore the potential to radically change the diagnostic standard of care for OC, ultimately saving lives and reducing the health, social and economic burden imposed by OC.

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The information about "EARLYDETECT" are provided by the European Opendata Portal: CORDIS opendata.

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