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CANDY SIGNED

Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy

Total Cost €

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EC-Contrib. €

0

Partnership

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 CANDY project word cloud

Explore the words cloud of the CANDY project. It provides you a very rough idea of what is the project "CANDY" about.

mechanisms    plasticity    personalized    autoimmune    time    shared    strategies    illnesses    dysregulation    intellectual    patient    caused    multimorbidity    periods    disease    spectrum    life    asd    lifespan    batteries    id    variants    stratification    candy    understand    dementia    people    rare    bases    smes    excitation    neurodevelopmental    guide    disability    leverage    acting    translational    disorder    inhibition    shows    mortality    academics    tools    diagnosis    stages    population    glutamate    hope    ndds    instance       deficit    heterogeneous    15    gastrointestinal    autism    final    subgroups    treatments    stroke    biomarkers    hence    gaba    immune    multidisciplinary    transform    hyperactivity    converge    neurotransmission    team    disorders    synaptic    prevention    spend    combination    activation    underpinning    treatment    mental    innovation    cancer    sensitive    monitoring    economic    adhd    imbalance    lack    genetic    data    medicine    risk    individuals    somatic    morbidity    valorization    first    played    world    clinically    landscape    co    epilepsy   

Project "CANDY" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 6˙000˙000 €
 EC max contribution 6˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 1˙615˙000.00
2    KING'S COLLEGE LONDON UK (LONDON) participant 825˙000.00
3    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 500˙000.00
4    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 425˙000.00
5    ARTTIC FR (PARIS) participant 350˙000.00
6    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 350˙000.00
7    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 300˙000.00
8    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 300˙000.00
9    UNIVERSITEIT GENT BE (GENT) participant 300˙000.00
10    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 250˙000.00
11    UNIVERSITAT BASEL CH (BASEL) participant 250˙000.00
12    NOLDUS INFORMATION TECHNOLOGY BV NL (WAGENINGEN) participant 200˙000.00
13    UNIVERSITAET ULM DE (ULM) participant 150˙000.00
14    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) participant 125˙000.00
15    ADD INFORMATION SERVICES UK (LONDON) participant 30˙000.00
16    AUTISME-EUROPE AISBL BE (BRUXELLES) participant 30˙000.00

Map

 Project objective

Neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and intellectual disability (ID) are clinically heterogeneous, often co-occur, affect ~15% of the EU population; and are associated with somatic illnesses (e.g. epilepsy, autoimmune and gastrointestinal disease) that lead to a significant increase in morbidity and mortality. For instance in ASD the combination of ID and epilepsy is associated with a reduction in lifespan of ~ 20 years; and an economic cost that is greater than cancer, stroke, or dementia. Yet, the research spend on NDDs is less than 1% of those disorders. Hence, we lack effective new treatments for NDDs and do not understand why they co-occur. There is hope, however. Recent evidence shows that rare genetic variants increasing risk for NDDs are shared, converge on final common pathways (e.g. synaptic plasticity, glutamate and GABA neurotransmission, and excitation/inhibition imbalance), and a key role is likely played by immune dysregulation. CANDY’s innovation is to test, for the first time, if NDDs, and their common mental and somatic multimorbidity, are caused by a combination(s) of common and rare genetic variants and immune activation acting at different ‘sensitive periods’. Our multidisciplinary team of world leading academics, patient organizations and SMEs will cost-effectively leverage existing EU-funded studies to 1) identify novel mechanisms underpinning NDDs and their multimorbidity, 2) develop new strategies for prevention and treatment, 3) deliver novel biomarkers to guide early diagnosis, stratification and/or treatment monitoring, and 4) provide open-access data bases, translational test batteries, and tools and targets for valorization. Together we will transform the landscape for people with NDDs and make possible personalized medicine approaches that target particular mechanisms, in specific subgroups of individuals and at different life stages.

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The information about "CANDY" are provided by the European Opendata Portal: CORDIS opendata.

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