Opendata, web and dolomites


Dipeptide-Repeat Vaccine to prevent ALS and FTD in C9orf72 mutation carriers

Total Cost €


EC-Contrib. €






 DPR-VAX project word cloud

Explore the words cloud of the DPR-VAX project. It provides you a very rough idea of what is the project "DPR-VAX" about.

halting    monogenic    diseases    translated    ftd    detection    complemented    poly    repeat    aggregates    regulatory    opportunity    generation    first    dpr    proteins    attractive    business    pathology    biomarkers    species    mutation    initial    als    preventing    clinical    families    prevents    class    realistic    ga    rapid    abundant    csf    aggregation    immunoassays    completely    motor    survival    generate    driver    therapies    causal    parallel    vaccine    dementia    symptoms    almost    carriers    sensitive    spin    vivo    space    proven    solid    venture    cns    protein    shown    data    triggered    dipeptide    external    mouse    pharmaceutical    reputable    companies    expertise    opment    expanded    create    aggregating    pet    mechanisms    rare    c9orf72    devel    shape    neurodegenerative    ready    poc    progression    gene    internal    deficits    preclinical    accelerate    off    erc    tracer    disease    not    trials    pharma    10    blessing    downstream    drug    fatal    frontotemporal    safety    sclerosis    fund    proposition    suitable    capitalists    strategy    validation    vaccination    experiment    antibodies    neuron    published    patient    society    expansion    clearance    dprs    model    multiple    patented    licensing    therapy    affairs    additional    amyotrophic    variants    reduces    lateral    monoclonal    optimize    caused    prevention   

Project "DPR-VAX" data sheet

The following table provides information about the project.


Organization address
city: BONN
postcode: 53127

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Neurodegenerative diseases are triggered by protein aggregation in the CNS, but developing therapies has been challenging. Since key disease mechanisms change during disease progression, halting further neuron loss has not been achieved and may not even improve the symptoms and survival. Causal therapy is most realistic for monogenic disease variants. About 10% of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases are caused by repeat expansion in the C9orf72 gene. We have shown that the expanded repeat is translated into multiple aggregating dipeptide repeat (DPR) proteins. Poly-GA, the most abundant DPR species, is a key driver of downstream pathology. A poly-GA vaccine reduces aggregates and almost completely prevents motor deficits in our mouse model. With additional validation and safety experiment we will generate a pharma-ready data package for rapid preclinical and clinical devel-opment of the vaccine as first-in-class drug for prevention of ALS and FTD in C9orf72 carriers. The parallel development of suitable biomarkers to show clearance of DPR aggregates in vivo will greatly accelerate clinical trials. Thus, we will optimize our published immunoassays to allow more sensitive detection of DPRs in patient CSF. Moreover, we will develop our patented DPR monoclonal antibodies into a PET tracer. The solid data package is complemented by internal and external expertise in business development and regulatory affairs to shape an attractive business proposition and create value. ERC-PoC funding will allow us to present the opportunity to potential partners in large pharmaceutical companies and reputable venture capitalists for licensing or spin-off generation. Another proven strategy in the rare disease space would be collaboration with patient organizations to fund initial clinical trials. Preventing fatal ALS and FTD using vaccination in C9orf72 mutation carriers would be cost-effective for society and a blessing for affected families.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DPR-VAX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DPR-VAX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  


Economic Fluctuations, Productivity Growth and Stabilization Policies: A Keynesian Growth Perspective

Read More  
lastchecktime (2022-08-14 12:18:33) correctly updated