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GONOGO SIGNED

Multi-layered integration of motivated actions and their outcomes in basal ganglia circuits

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GONOGO project word cloud

Explore the words cloud of the GONOGO project. It provides you a very rough idea of what is the project "GONOGO" about.

researcher    constitutes    respectively    suffering    depression    innovative    understand    mosquito    miniaturized    independent    imaging    implicated    ganglia    dysfunctional    supports    transgenic    interface    actions    basis    valences    cross    cream    neurons    simultaneous    outcome    crucially    receive    potentially    opposing    inform    impulsivity    valence    action    inter    interaction    input    chances    translational    psychiatric    traffic    impaired    disorders    basal    incomplete    modulating    fluorescence    tailor    repellant    neural    output    disciplinary    brain    insect    implantable    calcium    suppression    interacts    behavioral    indirect    hypothesize    street    ice    rewarding    manipulation    position    direct    fellowship    track    performing    strengthen    anticipated    aversive    ensemble    govern    anatomical    functional    neuronal    made    red    integration    microscopes    mechanisms    optogenetic    monitoring    green    initiation    dopamine    light    rats    serotonin    tenure    treatment    bite    stimuli    paradigm    wait    patients   

Project "GONOGO" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 187˙572.00

Map

 Project objective

We cross the street when the traffic light is green (action initiation), and we wait if it is red (action suppression), both in order to reach a goal across the street, such as getting an ice cream (rewarding) or insect-repellant to avoid a mosquito bite (aversive). Such action control is dysfunctional in several psychiatric disorders. For example, action initiation and suppression are impaired in patients suffering from depression and impulsivity, respectively. Thus, improving our incomplete understanding of the neural basis of action control has translational value, specifically how action outcome valence (rewarding or aversive) interacts with brain mechanisms of action control (i.e., initiation or suppression). The direct and indirect output pathways of the basal ganglia are strongly implicated in action initiation and suppression, respectively, and receive modulating input from dopamine and serotonin neurons, which are implicated in processing rewarding and aversive stimuli, respectively. I hypothesize that the anatomical and functional integration of these opposing systems supports action control as well as constitutes a neural interface for the interaction of action control and outcome valence. I propose to use a set of innovative and inter-disciplinary approaches that include monitoring neuronal ensemble activity with calcium imaging using implantable, miniaturized fluorescence microscopes and simultaneous optogenetic manipulation in novel transgenic rats performing in a tailor-made behavioral paradigm. I aim to understand the neural mechanisms in the basal ganglia that crucially govern the control over actions with different outcome valences. My anticipated results will inform future research and potentially treatment of psychiatric disorders such as depression and impulsivity disorders. Further, this fellowship will strengthen my position as an independent researcher and increase my chances for a tenure-track position at a European research institution.

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The information about "GONOGO" are provided by the European Opendata Portal: CORDIS opendata.

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