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GONOGO SIGNED

Multi-layered integration of motivated actions and their outcomes in basal ganglia circuits

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GONOGO project word cloud

Explore the words cloud of the GONOGO project. It provides you a very rough idea of what is the project "GONOGO" about.

imaging    depression    patients    traffic    dysfunctional    rats    bite    fluorescence    basis    translational    miniaturized    valence    dopamine    mosquito    modulating    researcher    innovative    interface    opposing    interaction    neurons    rewarding    interacts    ganglia    understand    monitoring    incomplete    behavioral    cross    suffering    aversive    valences    inform    crucially    ensemble    direct    initiation    mechanisms    stimuli    anticipated    disorders    repellant    paradigm    disciplinary    input    fellowship    implicated    action    potentially    anatomical    simultaneous    psychiatric    brain    impulsivity    supports    strengthen    light    respectively    neuronal    manipulation    impaired    red    transgenic    actions    integration    made    performing    ice    constitutes    outcome    basal    independent    street    calcium    govern    cream    implantable    tailor    neural    position    green    track    output    tenure    indirect    inter    suppression    optogenetic    hypothesize    functional    microscopes    wait    treatment    serotonin    receive    insect    chances   

Project "GONOGO" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 187˙572.00

Map

 Project objective

We cross the street when the traffic light is green (action initiation), and we wait if it is red (action suppression), both in order to reach a goal across the street, such as getting an ice cream (rewarding) or insect-repellant to avoid a mosquito bite (aversive). Such action control is dysfunctional in several psychiatric disorders. For example, action initiation and suppression are impaired in patients suffering from depression and impulsivity, respectively. Thus, improving our incomplete understanding of the neural basis of action control has translational value, specifically how action outcome valence (rewarding or aversive) interacts with brain mechanisms of action control (i.e., initiation or suppression). The direct and indirect output pathways of the basal ganglia are strongly implicated in action initiation and suppression, respectively, and receive modulating input from dopamine and serotonin neurons, which are implicated in processing rewarding and aversive stimuli, respectively. I hypothesize that the anatomical and functional integration of these opposing systems supports action control as well as constitutes a neural interface for the interaction of action control and outcome valence. I propose to use a set of innovative and inter-disciplinary approaches that include monitoring neuronal ensemble activity with calcium imaging using implantable, miniaturized fluorescence microscopes and simultaneous optogenetic manipulation in novel transgenic rats performing in a tailor-made behavioral paradigm. I aim to understand the neural mechanisms in the basal ganglia that crucially govern the control over actions with different outcome valences. My anticipated results will inform future research and potentially treatment of psychiatric disorders such as depression and impulsivity disorders. Further, this fellowship will strengthen my position as an independent researcher and increase my chances for a tenure-track position at a European research institution.

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The information about "GONOGO" are provided by the European Opendata Portal: CORDIS opendata.

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