PRIORITY

Protecting the food chain from prions: shaping European priorities through basic and applied research

 Coordinatore UNIVERSIDADE DE SANTIAGO DE COMPOSTELA 

 Organization address address: "PAZO DE SAN XEROME, PRAZA DO OBRADOIRO S/N"
city: SANTIAGO DE COMPOSTELA
postcode: 15782

contact info
Titolo: Mr.
Nome: Martin
Cognome: Cacheiro Martinez
Email: send email
Telefono: +34 881 816233
Fax: +34 881 816263

 Nazionalità Coordinatore Spain [ES]
 Sito del progetto http://www.prion-priority.eu/web/
 Totale costo 7˙904˙904 €
 EC contributo 5˙999˙499 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-2A
 Funding Scheme CP-IP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-10-01   -   2014-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSIDADE DE SANTIAGO DE COMPOSTELA

 Organization address address: "PAZO DE SAN XEROME, PRAZA DO OBRADOIRO S/N"
city: SANTIAGO DE COMPOSTELA
postcode: 15782

contact info
Titolo: Mr.
Nome: Martin
Cognome: Cacheiro Martinez
Email: send email
Telefono: +34 881 816233
Fax: +34 881 816263

ES (SANTIAGO DE COMPOSTELA) coordinator 564˙126.00
2    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Prof.
Nome: Adriano
Cognome: Aguzzi
Email: send email
Telefono: +41 44 255 2869
Fax: +41 44 255 44 02

CH (ZURICH) participant 438˙124.00
3    UNIVERSITAT DE BARCELONA

 Organization address address: GRAN VIA DE LES CORTS CATALANES 585
city: BARCELONA
postcode: 8007

contact info
Titolo: Mr.
Nome: Xavier
Cognome: Gutierrez
Email: send email
Telefono: +34 93 4035385
Fax: +34 93 4489434

ES (BARCELONA) participant 378˙124.00
4    FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT

 Organization address city: GREIFSWALD-INSEL RIEMS
postcode: 17493

contact info
Titolo: Ms.
Nome: Lorena
Cognome: Retana Calderon
Email: send email
Telefono: +49 383517 1351
Fax: +49 383517 1219

DE (GREIFSWALD-INSEL RIEMS) participant 361˙248.00
5    INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

 Organization address address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338

contact info
Titolo: Ms.
Nome: Michèle
Cognome: Serthelon
Email: send email
Telefono: +33 5 61 19 38 70
Fax: +33 5 61 19 39 75

FR (PARIS CEDEX 07) participant 348˙498.00
6    HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

 Organization address address: UNIVERSITAETSSTRASSE 1
city: DUSSELDORF
postcode: 40225

contact info
Titolo: Mr.
Nome: Peter
Cognome: Bons
Email: send email
Telefono: +49 211 8117127

DE (DUSSELDORF) participant 345˙874.00
7    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 1 40613378
Fax: +33 1 40613940

FR (PARIS CEDEX 15) participant 345˙874.00
8    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Ms.
Nome: Eva
Cognome: Tegelberg
Email: send email
Telefono: 46852487855
Fax: 468333834

SE (STOCKHOLM) participant 345˙874.00
9    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 131 6509024
Fax: +44 131 6509023

UK (EDINBURGH) participant 330˙874.00
10    UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

 Organization address address: Robert-Koch-Strasse 40
city: GOETTINGEN
postcode: 37075

contact info
Titolo: Ms.
Nome: Christiane
Cognome: Hennecke
Email: send email
Telefono: +49 551 398770
Fax: +49 551 3922593

DE (GOETTINGEN) participant 330˙874.00
11    PRIONICS AG

 Organization address address: WAGISTRASSE 27 A
city: SCHLIEREN
postcode: 8952

contact info
Titolo: Dr.
Nome: Alex
Cognome: Raeber
Email: send email
Telefono: +41 44 2002000
Fax: +41 44 2002009

CH (SCHLIEREN) participant 308˙374.00
12    SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI

 Organization address address: VIA BONOMEA 265
city: TRIESTE
postcode: 34136

contact info
Titolo: Ms.
Nome: Giuliana
Cognome: Zotta
Email: send email
Telefono: +39 040 3787201
Fax: +39 040 3787249

IT (TRIESTE) participant 308˙374.00
13    INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA

 Organization address address: Carretera de la Coruna Km7.5
city: MADRID
postcode: 28040

contact info
Titolo: Ms.
Nome: María
Cognome: Alarcón Alarcón
Email: send email
Telefono: +34 91 3473966
Fax: +34 91 3474084

ES (MADRID) participant 300˙892.00
14    STICHTING HET NEDERLANDS KANKER INSTITUUT

 Organization address address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX

contact info
Titolo: Dr.
Nome: Henri G. A. M.
Cognome: Van Luenen
Email: send email
Telefono: +31 20 5122097
Fax: +31 20 6691383

NL (AMSTERDAM) participant 295˙248.00
15    THE HEBREW UNIVERSITY OF JERUSALEM.

 Organization address address: GIVAT RAM CAMPUS
city: JERUSALEM
postcode: 91904

contact info
Titolo: Ms.
Nome: Jane
Cognome: Turner
Email: send email
Telefono: +972 2 6586676
Fax: +972 2 6513205

IL (JERUSALEM) participant 254˙748.00
16    SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE

 Organization address address: LIMBOVA 12
city: BRATISLAVA
postcode: 83303

contact info
Titolo: Mr.
Nome: Milan
Cognome: Cagan
Email: send email
Telefono: +421 2 59370 651
Fax: +421 2 59370 652

SK (BRATISLAVA) participant 239˙750.00
17    SMP GMBH - PRUEFEN VALIDIEREN FORSCHEN

 Organization address address: Hechinger strasse 262
city: TUBINGEN
postcode: 72072

contact info
Titolo: Mr.
Nome: Klaus
Cognome: Roth
Email: send email
Telefono: +49 7071 8578930
Fax: +49 7071 857893200

DE (TUBINGEN) participant 153˙874.00
18    UNIVERSITAET HOHENHEIM

 Organization address address: Schloss Hohenheim 1
city: STUTTGART
postcode: 70599

contact info
Titolo: Prof.
Nome: Hans-Peter
Cognome: Liebig
Email: send email
Telefono: +49 711 459 0
Fax: +49 711 459 24050

DE (STUTTGART) participant 153˙874.00
19    VETERINAERINSTITUTTET - NORWEGIAN VETERINARY INSTITUTE

 Organization address address: ULLEVALSVEIEN 68
city: OSLO
postcode: 454

contact info
Titolo: Mr.
Nome: Frode åsmund
Cognome: Granås
Email: send email
Telefono: +47 2321 6150
Fax: +47 2321 6001

NO (OSLO) participant 77˙375.00
20    UNIVERSITEIT MAASTRICHT

 Organization address address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD

contact info
Titolo: Mr.
Nome: Ralf
Cognome: Henskens
Email: send email
Telefono: +31 43 3881967
Fax: +31 43 3884163

NL (MAASTRICHT) participant 74˙000.00
21    THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS

 Organization address address: Area 1A, Nobel House, Smith Square 17
city: LONDON
postcode: SW1P 3JR

contact info
Titolo: Ms.
Nome: Lucinda
Cognome: Cranham
Email: send email
Telefono: +44 1932 359571
Fax: +44 1932 357230

UK (LONDON) participant 43˙500.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

bse    biology    years    formulated    prions    prion    infection    bovine    questions    chain    species    brain    human    encephalopathy    us    caused    mad    structure    function    ban    transmission    blood    meal    prpsc    infectious    exposure    humans    vcjd    cow    food    bone    molecular    found    risk    data    proteins    decontamination    disease    strategies    cjd    ago    strains    atypical    meat    tse    spongiform    prevent    infectivity    spread   

 Obiettivo del progetto (Objective)

'Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent “atypical cases” of BSE. Only a profound understanding of the molecular biology of prions will enable us to control them. Thus, to understand why BSE-contaminated food causes vCJD, we need to understand how prions get into food, what happens with them in the gut, how they reach the brain, and how they initiate the chain reaction rapidly leading to death. We have formulated 7 key questions: 1) How can we avoid a new BSE outbreak, or other possible future prion infection of livestock? 2) Why did decontamination of meat and bone meal fail; is there an effective way to decontaminate feedstuffs, soil etc? 3) What is the risk of humans being infected with each of the different prion strains known thus far? 4) Which are the best strategies to implement feasible prion eradication programs? 5) How can we develop a pre-clinical prion blood test? 6) How can we identify human cases with potential secondary transmission? And 7) What is the origin of atypical human CJD cases? We will search for decisive data on the structure of PrPSc, the molecular basis of strains and species barriers, the mechanism of prion conversion, the cell biology of PrPSc, the function of PrPC, and the mechanisms of PrP-associated pathology. This information will be translated into a better estimation of current exposure risk to humans from TSE, evaluation of current intervention strategies, and development of improved decontamination techniques and prion tests. With all this, we will be able to respond to the questions formulated and thus advise the EC on TSE policy for the protection of European consumers..'

Introduzione (Teaser)

Proteins in general are good for us; but mis-folded proteins known as prions that caused the infectious mad cow disease are a different story. An EU-supported project is studying prions in order to prevent a recurrence of mad-cow disease or variant Creutzfeldt-Jakob disease (vCJD).

Descrizione progetto (Article)

Bovine Spongiform Encephalopathy (BSE), also called mad cow disease, decimated European cow populations over 20 years ago and caused major food scares across Europe. It even leapt across the species barrier to infect some humans with vCJD, killing around 200 people.

BSE and CJD are both caused by prions (infectious agents composed of misfolded proteins). Extensive research is required to prevent or deal with emergence of diseases due to prion infection.

Funded under the Seventh Framework Programme (FP7), the PRIORITY project sought to protect Europe's food chain by improving our understanding of prions. The EU-backed project focused on four areas related to prions: structure and function, detection, transmission and their epidemiology.

To investigate the structure of different prions, PRIORITY used cryo-electron microscopy and tomography, as well as various biochemical approaches. The project also studied how prions spread within an organism (including the brain) and the infectivity dynamics of blood and milk. Researchers found that prions spread from exposure site to brain via accumulation in follicular dendritic cells (FDCs).

PRIORITY confirmed that the ban on meat and bone meal (MBM) was the most significant factor supporting the containment of BSE, and recommended continuing the ban. TThe project also found that prion infectivity is quite persistent in wastewater.

Once complete, PRIORITY will help the EU deliver one of its major food safety priorities: safeguarding the food chain from fork to farm. Research data could identify factors that help prions flourish and spread across different species and the means to disrupt it.

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ENVIEVAL (2013)

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