EU-GEI

European Network of National Schizophrenia Networks Studying Gene-Environment Interactions

 Coordinatore UNIVERSITEIT MAASTRICHT 

 Organization address address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD

contact info
Titolo: Mr.
Nome: Laurent
Cognome: Louwies
Email: send email
Telefono: 31433884106
Fax: 31433875444

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://www.eu-gei.eu
 Totale costo 15˙030˙922 €
 EC contributo 11˙616˙855 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2009-single-stage
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-05-01   -   2015-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT

 Organization address address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD

contact info
Titolo: Mr.
Nome: Laurent
Cognome: Louwies
Email: send email
Telefono: 31433884106
Fax: 31433875444

NL (MAASTRICHT) coordinator 1˙340˙958.26
2    CARDIFF UNIVERSITY

 Organization address address: Newport Road 30-36
city: CARDIFF
postcode: CF24 ODE

contact info
Titolo: Mr.
Nome: Nick
Cognome: Bodycombe
Email: send email
Telefono: 442921000000
Fax: 442921000000

UK (CARDIFF) participant 2˙798˙872.00
3    SERVICIO MADRILENO DE SALUD

 Organization address address: PLAZA CARLOS TRIAS BERTRAN 7
city: MADRID
postcode: 28020

contact info
Titolo: Dr.
Nome: Antonio
Cognome: Barba Ruíz De Gauna
Email: send email
Telefono: +34 914 265 115
Fax: +34 914 008 156

ES (MADRID) participant 1˙181˙892.00
4    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Mr.
Nome: Paul
Cognome: Biersteker
Email: send email
Telefono: 31205666265
Fax: 31206915462

NL (AMSTERDAM) participant 1˙071˙201.00
5    ANKARA UNIVERSITESI

 Organization address address: DOGOL CADDESI
city: TANDOGAN ANKARA
postcode: 6100

contact info
Titolo: Prof.
Nome: Meram
Cognome: Saka
Email: send email
Telefono: +90 312 595 7223
Fax: +90 312 320 3696

TR (TANDOGAN ANKARA) participant 1˙042˙418.00
6    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Prof.
Nome: Philip
Cognome: Mcguire
Email: send email
Telefono: 442078000000
Fax: +4420 7848 0976

UK (LONDON) participant 1˙031˙012.74
7    ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

 Organization address address: Square J 5
city: MANNHEIM
postcode: 68159

contact info
Titolo: Ms.
Nome: Simone
Cognome: Fuchs
Email: send email
Telefono: 4962120000000
Fax: 4962120000000

DE (MANNHEIM) participant 776˙617.00
8    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Dr.
Nome: Elke
Cognome: Lammertyn
Email: send email
Telefono: +32 16 32 06 21
Fax: +32 16 326515

BE (LEUVEN) participant 414˙000.00
9    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Evelyne
Cognome: Lasfargues
Email: send email
Telefono: 33145172677
Fax: 33148995407

FR (PARIS) participant 350˙560.00
10    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Mr.
Nome: Keith
Cognome: Cann
Email: send email
Telefono: +44 1223 333543
Fax: +44 1223 332988

UK (CAMBRIDGE) participant 194˙940.00
11    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA

 Organization address address: BARRIO SARRIENA S N
city: LEIOA
postcode: 48940

contact info
Titolo: Ms.
Nome: Ione
Cognome: Isasa
Email: send email
Telefono: 34946012895
Fax: 34946013550

ES (LEIOA) participant 184˙998.00
12    The University of Hong Kong

 Organization address address: Pokfulam Road
city: Pokfulam

contact info
Titolo: Ms.
Nome: Kate
Cognome: Yip
Email: send email
Telefono: +852 22415266
Fax: +852 28030558

HK (Pokfulam) participant 179˙940.00
13    WINGZ BV

 Organization address address: HIGH TECH CAMPUS 9
city: Eindhoven
postcode: 5656 AE

contact info
Titolo: Ms.
Nome: Vera
Cognome: Veeren
Email: send email
Telefono: 31889464928
Fax: 31889464939

NL (Eindhoven) participant 175˙405.00
14    E.C.S. INTERNATIONAL BV

 Organization address address: Walburg 12
city: Maastricht
postcode: 6225CM

contact info
Titolo: Mr.
Nome: Peter
Cognome: Emonds
Email: send email
Telefono: 31433625628
Fax: 31433625628

NL (Maastricht) participant 163˙154.00
15    KLINIKUM DER UNIVERSITAET ZU KOELN

 Organization address address: Kerpener Strasse 62
city: KOELN
postcode: 50937

contact info
Titolo: Ms.
Nome: Jutta
Cognome: Landvogt
Email: send email
Telefono: 492215000000
Fax: 4922150000000

DE (KOELN) participant 112˙905.00
16    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Prof.
Nome: Anita
Cognome: Riecher-Rössler
Email: send email
Telefono: 41612655114
Fax: 41612654599

CH (BASEL) participant 109˙171.00
17    MEDIZINISCHE UNIVERSITAET WIEN

 Organization address address: SPITALGASSE 23
city: WIEN
postcode: 1090

contact info
Titolo: Prof.
Nome: Siegfried
Cognome: Kasper
Email: send email
Telefono: 431404000000
Fax: 431404000000

AT (WIEN) participant 108˙915.00
18    SERMES PLANIFICACION

 Organization address address: CALLE RUFINO GONZALEZ 14
city: MADRID
postcode: 28037

contact info
Titolo: Ms.
Nome: Anna
Cognome: Jurczynska
Email: send email
Telefono: 34913756930
Fax: 34913756931

ES (MADRID) participant 75˙500.00
19    ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA

 Organization address address: Via Zamboni 33
city: BOLOGNA
postcode: 40126

contact info
Titolo: Ms.
Nome: Verdiana
Cognome: Bandini
Email: send email
Telefono: 390512000000
Fax: 390512000000

IT (BOLOGNA) participant 73˙224.00
20    UNIVERSITA DEGLI STUDI DI PALERMO

 Organization address address: PIAZZA MARINA 61
city: PALERMO
postcode: 90133

contact info
Titolo: Mr.
Nome: Giacomo Antonio
Cognome: Aiello
Email: send email
Telefono: +39 091 6554236
Fax: +39 091 6554202

IT (PALERMO) participant 72˙000.00
21    ROYAL COLLEGE OF SURGEONS IN IRELAND

 Organization address address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
Titolo: Mr.
Nome: Barry
Cognome: Mcgowan
Email: send email
Telefono: 35314022478
Fax: 35314022450

IE (DUBLIN) participant 54˙000.00
22    MEDIAMENS B.V.

 Organization address address: MILAANSTRAAT 70
city: SITTARD
postcode: 6135LH

contact info
Titolo: Ms.
Nome: Daniëlle
Cognome: Dohmen
Email: send email
Telefono: 31464008616
Fax: 31847468736

NL (SITTARD) participant 53˙172.00
23    Omega Pro Proje Arastirma Gelistirme ve Danismanlik Ltd ?ti

 Organization address address: CYBERPLAZA C BLOK 3 KAT 22
city: Ankara
postcode: 6800

contact info
Titolo: Mr.
Nome: Berk
Cognome: Ozdemir
Email: send email
Telefono: 903123000000
Fax: 903124000000

TR (Ankara) participant 40˙000.00
24    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Nome: Alexander
Cognome: Vogl
Email: send email
Telefono: 498971000000
Fax: 498971000000

DE (MUENCHEN) participant 12˙000.00
25    UNIVERSITY MENTAL HEALTH RESEARCH INSTITUTE

 Organization address address: SORANOU TOU EFESSIOU ST. 2
city: ATHENS
postcode: 11527

contact info
Titolo: Ms.
Nome: Eleni
Cognome: Kavadia
Email: send email
Telefono: 302106000000
Fax: 302106000000

EL (ATHENS) participant 0.00
26    UNIVERSITY OF MELBOURNE

 Organization address address: PARKVILLEOFFICE OF THE VICE CHANCELLOR
city: MELBOURNE
postcode: 3010

contact info
Titolo: Mr.
Nome: Adriaan
Cognome: Adolph
Email: send email
Telefono: +61 3 8344 2016
Fax: +61 3 9347 6739

AU (MELBOURNE) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

individuals    clinical    behavioural    charts    cohorts    samples    helps    flow    severity    gei    treatment    schizophrenia    risk    mental    mechanisms    evaluation    multidisciplinary    underlying    functional    disorders    interactions    family    people    psymate    interactive    disorder    prediction    environment    psychotic    diagnosis    person    statistical    tool    momentary    patients    networks    outcome    experiences    latest    life    gene    twin    variables    psychosis    determinants    genetic    data    environmental    health    lives    tools    course   

 Obiettivo del progetto (Objective)

'The aim of EU-GEI is to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order to identify these interactive determinants, EU-GEI will employ family-based, multidisciplinary research paradigms, which allow for the efficient assessment of gene-environment interactions. In order to go beyond old findings from historical convenience cohorts with crude measures of environmental factors and clinical outcomes, the focus in EU-GEI will be on recruitment of new, family-based clinical samples with state-of-the-art assessments of environmental, clinical and genetic determinants as well as their underlying neural and behavioural mechanisms. New statistical tools will be developed to combine the latest multilevel epidemiological with the latest genome-wide genetic approaches to analysis. Translation of results to clinical practice will be facilitated by additional experimental research and risk assessment bioinformatics approaches. This will result in the identification of modifiable biological and cognitive mechanisms underlying gene-environment interactions and the construction of Risk Assessment Charts and Momentary Assessment Technology tools which can be used for (i) early prediction of transition to psychotic disorder in help-seeking individuals with an at-risk mental state and (ii) early prediction of course and outcome after illness onset. In order to reach these goals, EU-GEI has assembled a multidisciplinary team of top schizophrenia researchers who have the range of skills required to deliver a program of research that meets all the call’s requirements and who have access to / will collect a number of unique European samples. The partners in EU-GEI represent the nationally funded schizophrenia / mental health networks of the UK, Netherlands, France, Spain, Turkey and Germany as well as other partners.'

Introduzione (Teaser)

Up to 3 % of people develop a psychotic disorder in the course of their lives, and approximately 1 % develop schizophrenia, one type of psychotic disorder. European researchers, together with international partners, are looking into measuring the genetic, clinical and environmental factors and mechanisms that determine the development, severity and outcome of schizophrenia.

Descrizione progetto (Article)

People with psychotic disorders are overwhelmed by inner experiences that disturb their ability to connect in an adequate way with their social environment. Importantly, there is currently no reliable method allowing prediction of the risk of an individual to develop a psychotic disorder.

The risk of developing a psychotic disorder is known to be related in particular to both a person's genetic make-up, and environmental factors during his/her course of life. These factors include adversity during childhood, belonging to a society's minority group, drug addiction, or just living in a city rather than in a rural environment. Twin studies show that susceptibility to developing a psychotic disorder may be to 50 % determined by genetics. It is assumed, but still needs to be rigorously tested, that a person's genetic make-up also influences the role that environmental factors can play to enhance/or decrease risk for psychiatric disorders to develop.

To address this key question, a multidisciplinary, multinational collaboration within, and beyond, Europe has been initiated, the EU-funded 'European network of national schizophrenia networks studying gene-environment interactions' project (http://www.eu-gei.eu (EU-GEI)).

EU-GEI is investigating genetic, environmental, behavioural and clinical variables in samples and data from more than 7 500 individuals, including families of patients with psychotic disorders, twin pairs and individuals from the general population.

In order to better understand fluctuations in behaviour and experiences in the flow of daily life, EU-GEI scientists have developed the PSYMATE device and application. This data collection and software tool, is able to capture multiple parameters during moments in the flow of people's everyday life, and is thus providing a 'film' rather than a 'snapshot' of the patient's day. Data from the PSYMATE tool helps to empower patients in managing their own lives, helps clinicians in terms of diagnosis and it can contribute to the evaluation of mental health care interventions.

The EU-GEI website is up and running, providing both information for the general public and patients as well as a web-based training package available for researchers in the centres that are participating in the clinical study under the project.

A fully functional database has been established that handles the large quantities of incoming data from the large EU-GEI cohorts that will provide the largest set of data available on genetic, environmental, behavioural and clinical variables in psychosis, in particular schizophrenia. DNA samples collected under the EU-GEI study are all genotyped in the project's centralised genotyping facilities, and a large number of subjects have already been genetically analysed.

Approaches for statistical analyses of the complex EU-GEI data sets have been developed and are currently in use. The full data set from the Dutch part of the study has become available and is currently under investigation for genotype x environment interactions. First explorations have already provided replicated evidence that the impact of cannabis use on psychosis is moderated in people that carry a specific variant of the AKT1 gene.

Considerable progress has been made in discovering genetic variants that increase risk for schizophrenia. Moreover, functional neuroimaging studies have discovered correlates of environmental exposures in the brain.

The prime clinical relevance of the EU-GEI project will be the establishment of risk assessment charts based on genetic, environmental, behavioural and clinical variables. These momentary assessment tools, which are amendable to predict risk to develop clinical manifestation of psychotic disorders, will significantly improve diagnosis, treatment outcome prediction and treatment evaluation.

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