Immuno-NanoDecoder SIGNED
Nanostructured molecular decoders for the quantitative, multiplexed, layer-by-layer detection of disease-associated proteins
Total Cost €
0EC-Contrib. €
0Partnership
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Project "Immuno-NanoDecoder" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 441˙000 € |
| EC max contribution | 441˙000 € (100%) |
| Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
| Code Call | H2020-MSCA-RISE-2014 |
| Funding Scheme | MSCA-RISE |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-01 to 2019-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA | IT (ROMA) | coordinator | 198˙000.00 |
| 2 | AZIENDA SANITARIA UNIVERSITARIA INTEGRATA DI UDINE | IT (UDINE) | participant | 180˙000.00 |
| 3 | UNIVERSITY OF LINCOLN | UK (LINCOLN) | participant | 63˙000.00 |
| 4 | CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) | AR (BUENOS AIRES) | partner | 0.00 |
| 5 | Temple University-Of The Commonwealth System of Higher Education | US (Philadelphia) | partner | 0.00 |
Map
Project objective
The long-range goal of this project is to develop a molecular nanodevice, based on nucleic acid-protein conjugates, for the multiplexed, quantitative imaging of biomarkers in tissue samples and cultured cells. The Immuno-nanodecoder will be used for the accurate molecular characterization of skin cancer (melanoma) and glycogenosis type II cellular models and to evaluate the in vitro response to experimental therapies. The nanodevices (nanodecoders) will consist of self-assembled DNA nanostructures that can reversibly change their fluorescence signal output in response to hybridization to nucleic acid sequences, or to a specific enzymatic reaction. Each nanodevice will be coupled to a specific molecular probe, such as an antibody, peptide, or protein that uniquely recognize disease biomarkers. The coupling will allow the nanodecoder to detect biomarker presence and distribution in cells and tissues, in a layer-by-layer fashion, using optical fluorescence microscopy. The number of biomarkers that can be detected will be limited only by the capacity to design nanodecoders with differing specificities, which is essentially unlimited. The creation of nanodecoders and optimization of their function will greatly advance biomarker imaging, which currently lacks a high-throughput, convenient method for the in situ, quantitative microscopic analysis of altered tissue regions. This project will be driven by knowledge exchange and the expertise of an interdisciplinary team comprised of both early-stage and experienced university and hospital researchers. Complementary research programs, ranging from nanotechnology to molecular medicine and pathology will support each step of the developmental and applicative parts of the project towards the achievement of its objectives. Funding of this program will enable long-term, transformative collaborations that will contribute to the integration and collaboration of research groups between European Countries and key Third Countries.
Deliverables
| D3.4 | Demonstrators, pilots, prototypes | 2019-07-24 10:31:19 |
| D1.6 | Demonstrators, pilots, prototypes | 2019-07-23 16:23:00 |
| D6.1.4 | Documents, reports | 2019-07-22 17:08:12 |
| D1.4 | Demonstrators, pilots, prototypes | 2019-07-22 17:08:11 |
| D4.3 | Demonstrators, pilots, prototypes | 2019-07-24 10:31:15 |
| D4.4 | Demonstrators, pilots, prototypes | 2019-07-24 10:31:17 |
| D2.6 | Demonstrators, pilots, prototypes | 2019-07-22 17:06:51 |
| D5.3 | Other | 2019-07-22 17:07:35 |
| D2.5 | Demonstrators, pilots, prototypes | 2019-07-24 10:31:20 |
| D2.2 | Demonstrators, pilots, prototypes | 2019-07-24 10:31:34 |
| D6.1.6 | Documents, reports | 2019-07-24 10:31:14 |
| D6.4.1 | Demonstrators, pilots, prototypes | 2019-07-23 16:23:04 |
| D5.2 | Other | 2019-07-24 10:31:15 |
| D6.1.5 | Documents, reports | 2019-07-23 16:23:04 |
| D5.4 | Other | 2019-07-22 17:07:59 |
| D1.5 | Demonstrators, pilots, prototypes | 2019-07-22 17:08:14 |
| D6.3.1 | Documents, reports | 2019-07-23 16:23:07 |
| D4.1 | Other | 2019-07-22 17:07:36 |
| D5.5 | Demonstrators, pilots, prototypes | 2019-07-22 17:07:35 |
| D5.1 | Other | 2019-07-22 17:07:35 |
| D4.2 | Other | 2019-07-22 17:07:31 |
| D2.3 | Demonstrators, pilots, prototypes | 2019-07-24 10:31:20 |
| D6.1.7 | Documents, reports | 2019-07-23 16:23:05 |
| D2.4 | Demonstrators, pilots, prototypes | 2019-07-22 17:06:50 |
| D2.8 | Other | 2019-07-22 17:06:48 |
| D2.7 | Documents, reports | 2019-07-22 17:06:49 |
| D3.3 | Other | 2019-07-22 17:06:49 |
| D1.3 | Demonstrators, pilots, prototypes | 2019-07-22 17:08:13 |
| D1.8 | Other | 2019-07-22 17:08:11 |
| D1.2 | Demonstrators, pilots, prototypes | 2019-07-22 17:07:36 |
| D3.2 | Other | 2019-05-30 11:40:56 |
| D6.1.2 | Documents, reports | 2019-05-30 11:41:05 |
| D2.1 | Demonstrators, pilots, prototypes | 2019-05-30 11:41:02 |
| D3.1 | Other | 2019-05-30 11:41:00 |
| D6.1.3 | Documents, reports | 2019-05-30 11:41:06 |
| D1.1 | Demonstrators, pilots, prototypes | 2019-05-30 11:40:58 |
| D6.1.1 | Documents, reports | 2019-05-30 11:41:03 |
| D1.7 | Documents, reports | 2019-05-30 11:41:07 |
Take a look to the deliverables list in detail: detailed list of Immuno-NanoDecoder deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Anish Parmar, Abhishek Iyer, Stephen H. Prior, Daniel G. Lloyd, Eunice Tze Leng Goh, Charlotte S. Vincent, Timea Palmai-Pallag, Csanad Z. Bachrati, Eefjan Breukink, Annemieke Madder, Rajamani Lakshminarayanan, Edward J. Taylor, Ishwar Singh Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding published pages: 8183-8192, ISSN: 2041-6520, DOI: 10.1039/c7sc03241b |
Chemical Science 8/12 | 2019-08-05 |
| 2018 |
Wenwei Ma, Angela Saccardo, Danilo Roccatano, Dorothy Aboagye-Mensah, Mohammad Alkaseem, Matthew Jewkes, Francesca Di Nezza, Mark Baron, Mikhail Soloviev, Enrico Ferrari Modular assembly of proteins on nanoparticles published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03931-4 |
Nature Communications 9/1 | 2019-05-30 |
| 2017 |
W. Ma, D. Aboagye-Mensah, M. Soloviev, B. Davletov, E. Ferrari Protein Conjugation to Nanoparticles by Designer Affinity Tags published pages: 6923-6929, ISSN: 2214-7853, DOI: 10.1016/j.matpr.2017.07.021 |
Materials Today: Proceedings 4/7 | 2019-05-30 |
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