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Immuno-NanoDecoder SIGNED

Nanostructured molecular decoders for the quantitative, multiplexed, layer-by-layer detection of disease-associated proteins

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Immuno-NanoDecoder project word cloud

Explore the words cloud of the Immuno-NanoDecoder project. It provides you a very rough idea of what is the project "Immuno-NanoDecoder" about.

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Project "Immuno-NanoDecoder" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA 

Organization address
address: VIA CRACOVIA 50
city: ROMA
postcode: 133
website: www.uniroma2.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 441˙000 €
 EC max contribution 441˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA IT (ROMA) coordinator 198˙000.00
2    AZIENDA SANITARIA UNIVERSITARIA INTEGRATA DI UDINE IT (UDINE) participant 180˙000.00
3    UNIVERSITY OF LINCOLN UK (LINCOLN) participant 63˙000.00
4    CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) AR (BUENOS AIRES) partner 0.00
5    Temple University-Of The Commonwealth System of Higher Education US (Philadelphia) partner 0.00

Map

 Project objective

The long-range goal of this project is to develop a molecular nanodevice, based on nucleic acid-protein conjugates, for the multiplexed, quantitative imaging of biomarkers in tissue samples and cultured cells. The Immuno-nanodecoder will be used for the accurate molecular characterization of skin cancer (melanoma) and glycogenosis type II cellular models and to evaluate the in vitro response to experimental therapies. The nanodevices (nanodecoders) will consist of self-assembled DNA nanostructures that can reversibly change their fluorescence signal output in response to hybridization to nucleic acid sequences, or to a specific enzymatic reaction. Each nanodevice will be coupled to a specific molecular probe, such as an antibody, peptide, or protein that uniquely recognize disease biomarkers. The coupling will allow the nanodecoder to detect biomarker presence and distribution in cells and tissues, in a layer-by-layer fashion, using optical fluorescence microscopy. The number of biomarkers that can be detected will be limited only by the capacity to design nanodecoders with differing specificities, which is essentially unlimited. The creation of nanodecoders and optimization of their function will greatly advance biomarker imaging, which currently lacks a high-throughput, convenient method for the in situ, quantitative microscopic analysis of altered tissue regions. This project will be driven by knowledge exchange and the expertise of an interdisciplinary team comprised of both early-stage and experienced university and hospital researchers. Complementary research programs, ranging from nanotechnology to molecular medicine and pathology will support each step of the developmental and applicative parts of the project towards the achievement of its objectives. Funding of this program will enable long-term, transformative collaborations that will contribute to the integration and collaboration of research groups between European Countries and key Third Countries.

 Deliverables

List of deliverables.
D3.4 Demonstrators, pilots, prototypes 2019-07-24 10:31:19
D1.6 Demonstrators, pilots, prototypes 2019-07-23 16:23:00
D6.1.4 Documents, reports 2019-07-22 17:08:12
D1.4 Demonstrators, pilots, prototypes 2019-07-22 17:08:11
D4.3 Demonstrators, pilots, prototypes 2019-07-24 10:31:15
D4.4 Demonstrators, pilots, prototypes 2019-07-24 10:31:17
D2.6 Demonstrators, pilots, prototypes 2019-07-22 17:06:51
D5.3 Other 2019-07-22 17:07:35
D2.5 Demonstrators, pilots, prototypes 2019-07-24 10:31:20
D2.2 Demonstrators, pilots, prototypes 2019-07-24 10:31:34
D6.1.6 Documents, reports 2019-07-24 10:31:14
D6.4.1 Demonstrators, pilots, prototypes 2019-07-23 16:23:04
D5.2 Other 2019-07-24 10:31:15
D6.1.5 Documents, reports 2019-07-23 16:23:04
D5.4 Other 2019-07-22 17:07:59
D1.5 Demonstrators, pilots, prototypes 2019-07-22 17:08:14
D6.3.1 Documents, reports 2019-07-23 16:23:07
D4.1 Other 2019-07-22 17:07:36
D5.5 Demonstrators, pilots, prototypes 2019-07-22 17:07:35
D5.1 Other 2019-07-22 17:07:35
D4.2 Other 2019-07-22 17:07:31
D2.3 Demonstrators, pilots, prototypes 2019-07-24 10:31:20
D6.1.7 Documents, reports 2019-07-23 16:23:05
D2.4 Demonstrators, pilots, prototypes 2019-07-22 17:06:50
D2.8 Other 2019-07-22 17:06:48
D2.7 Documents, reports 2019-07-22 17:06:49
D3.3 Other 2019-07-22 17:06:49
D1.3 Demonstrators, pilots, prototypes 2019-07-22 17:08:13
D1.8 Other 2019-07-22 17:08:11
D1.2 Demonstrators, pilots, prototypes 2019-07-22 17:07:36
D3.2 Other 2019-05-30 11:40:56
D6.1.2 Documents, reports 2019-05-30 11:41:05
D2.1 Demonstrators, pilots, prototypes 2019-05-30 11:41:02
D3.1 Other 2019-05-30 11:41:00
D6.1.3 Documents, reports 2019-05-30 11:41:06
D1.1 Demonstrators, pilots, prototypes 2019-05-30 11:40:58
D6.1.1 Documents, reports 2019-05-30 11:41:03
D1.7 Documents, reports 2019-05-30 11:41:07

Take a look to the deliverables list in detail:  detailed list of Immuno-NanoDecoder deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Anish Parmar, Abhishek Iyer, Stephen H. Prior, Daniel G. Lloyd, Eunice Tze Leng Goh, Charlotte S. Vincent, Timea Palmai-Pallag, Csanad Z. Bachrati, Eefjan Breukink, Annemieke Madder, Rajamani Lakshminarayanan, Edward J. Taylor, Ishwar Singh
Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding
published pages: 8183-8192, ISSN: 2041-6520, DOI: 10.1039/c7sc03241b
Chemical Science 8/12 2019-08-05
2018 Wenwei Ma, Angela Saccardo, Danilo Roccatano, Dorothy Aboagye-Mensah, Mohammad Alkaseem, Matthew Jewkes, Francesca Di Nezza, Mark Baron, Mikhail Soloviev, Enrico Ferrari
Modular assembly of proteins on nanoparticles
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03931-4
Nature Communications 9/1 2019-05-30
2017 W. Ma, D. Aboagye-Mensah, M. Soloviev, B. Davletov, E. Ferrari
Protein Conjugation to Nanoparticles by Designer Affinity Tags
published pages: 6923-6929, ISSN: 2214-7853, DOI: 10.1016/j.matpr.2017.07.021
Materials Today: Proceedings 4/7 2019-05-30

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