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Very fast Imaging by Broadband coherent RAman

Total Cost €


EC-Contrib. €






 VIBRA project word cloud

Explore the words cloud of the VIBRA project. It provides you a very rough idea of what is the project "VIBRA" about.

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Project "VIBRA" data sheet

The following table provides information about the project.


Organization address
city: MILANO
postcode: 20133

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 1˙822˙500 €
 EC max contribution 1˙822˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 1˙822˙500.00


 Project objective

The VIBRA project aims at developing an innovative microscope for real-time non-invasive imaging of cells and tissues, which promises to have a revolutionary impact on several fields of biology and medicine. Chemically specific vibrational signatures of molecules enable their direct structural characterization. Reliable and quantitative endogenous bio-markers can be established, e.g., to follow cell differentiation and to identify crucial properties of tissues (malignant vs benign phenotype of a tumour). In this way neoplasms can be located and their borders with normal tissue traced for surgery.

Spontaneous Raman spectroscopy demonstrated this capability, but it is intrinsically too slow for imaging. Coherent Raman microscopy, on the other hand, can reach extremely high speed (up to the video rate) but at the expense of poor chemical selectivity, being limited to a single vibrational frequency.

The ground-breaking goal of VIBRA is to combine the most detailed molecular information over the entire vibrational spectrum with the highest acquisition speed. The PI will develop a complete coherent Raman microscope for near-video-rate broadband vibrational imaging. This high risk/high gain goal will be achieved by the combination of four key developments: improved pulsed laser source; optimized non-linear interaction, enhancing the signal; increase in acquisition speed, thanks to innovative spectrometers; parallel on-board data processing.

In the final application phase, the VIBRA project will validate the performances of the novel vibrational imaging system studying two important bio-medical problems: cancerous cell differentiation and detection of neuronal tumours. This will pave the way towards future “virtual histopathology”: intraoperative non-invasive evaluation of cancerous tissue. My vision is to allow researchers and doctors without a specific knowledge in lasers and optics to routinely visualize functional properties of cells and tissues in vivo.


year authors and title journal last update
List of publications.
2017 Antonio Perri, Fabrizio Preda, Cosimo D’Andrea, Erling Thyrhaug, Giulio Cerullo, Dario Polli, Jürgen Hauer
Excitation-emission Fourier-transform spectroscopy based on a birefringent interferometer
published pages: A483, ISSN: 1094-4087, DOI: 10.1364/oe.25.00a483
Optics Express 25/12 2020-02-04
2019 A. Ragni, G. Sciortino, M. Sampietro, G. Ferrari, D. Polli
Multi-channel lock-in based differential front-end for broadband Raman spectroscopy
published pages: 44-49, ISSN: 0167-9260, DOI: 10.1016/j.vlsi.2019.03.001
Integration 67 2020-02-04
2018 Maida De Bortoli, Elena Taverna, Elisa Maffioli, Patrizia Casalini, Francesco Crisafi, Vikas Kumar, Claudio Caccia, Dario Polli, Gabriella Tedeschi, Italia Bongarzone
Lipid accumulation in human breast cancer cells injured by iron depletors
published pages: 1-17, ISSN: 1756-9966, DOI: 10.1186/s13046-018-0737-z
Journal of Experimental & Clinical Cancer Research 37/1 2019-08-30
2018 Fabrizio Preda, Antonio Perri, Julien Réhault, Biplab Dutta, Jan Helbing, Giulio Cerullo, Dario Polli
Time-domain measurement of optical activity by an ultrastable common-path interferometer
published pages: 1882, ISSN: 0146-9592, DOI: 10.1364/ol.43.001882
Optics Letters 43/8 2019-09-02
2018 Dario Polli, Vikas Kumar, Carlo M. Valensise, Marco Marangoni, Giulio Cerullo
Broadband Coherent Raman Scattering Microscopy
published pages: 1800020, ISSN: 1863-8880, DOI: 10.1002/lpor.201800020
Laser & Photonics Reviews 12/9 2019-08-30
2018 Vikas Kumar, Alejandro De la Cadena, Antonio Perri, Fabrizio Preda, Nicola Coluccelli, Giulio Cerullo, Dario Polli
Invited Article: Complex vibrational susceptibility by interferometric Fourier transform stimulated Raman scattering
published pages: 92403, ISSN: 2378-0967, DOI: 10.1063/1.5034114
APL Photonics 3/9 2019-06-06
2019 Erling Thyrhaug, Stefan Krause, Antonio Perri, Giulio Cerullo, Dario Polli, Tom Vosch, Jürgen Hauer
Single-molecule excitation–emission spectroscopy
published pages: 201808290, ISSN: 0027-8424, DOI: 10.1073/pnas.1808290116
Proceedings of the National Academy of Sciences Feb 2019 2019-03-11
2017 Antonio Perri, Fabrizio Preda, Cosimo D’Andrea, Erling Thyrhaug, Giulio Cerullo, Dario Polli, Jürgen Hauer
Excitation-emission Fourier-transform spectroscopy based on a birefringent interferometer
published pages: A483, ISSN: 1094-4087, DOI: 10.1364/OE.25.00A483
Optics Express 25/12 2019-06-06
2017 Nicola Coluccelli, Daniele Viola, Vikas Kumar, Antonio Perri, Marco Marangoni, Giulio Cerullo, Dario Polli
Tunable 30  fs light pulses at 1  W power level from a Yb-pumped optical parametric oscillator
published pages: 4545, ISSN: 0146-9592, DOI: 10.1364/OL.42.004545
Optics Letters 42/21 2019-06-06
2017 Francesco Crisafi, Vikas Kumar, Tullio Scopigno, Marco Marangoni, Giulio Cerullo, Dario Polli
In-line balanced detection stimulated Raman scattering microscopy
published pages: 8, ISSN: 2045-2322, DOI: 10.1038/s41598-017-09839-1
Scientific Reports 7/1 2019-06-06
2016 Francesco Saltarelli, Vikas Kumar, Daniele Viola, Francesco Crisafi, Fabrizio Preda, Giulio Cerullo, Dario Polli
Broadband stimulated Raman scattering spectroscopy by a photonic time stretcher
published pages: 21264, ISSN: 1094-4087, DOI: 10.1364/OE.24.021264
Optics Express 24/19 2019-06-06
2015 Julien Réhault, Francesco Crisafi, Vikas Kumar, Gustavo Ciardi, Marco Marangoni, Giulio Cerullo, Dario Polli
Broadband stimulated Raman scattering with Fourier-transform detection
published pages: 25235, ISSN: 1094-4087, DOI: 10.1364/OE.23.025235
Optics Express 23/19 2019-06-06
2017 Fabrizio Preda, Aurelio Oriana, Julien Rehault, Lucia Lombardi, Andrea C. Ferrari, Giulio Cerullo, Dario Polli
Linear and Nonlinear Spectroscopy by a Common-Path Birefringent Interferometer
published pages: 1-9, ISSN: 1077-260X, DOI: 10.1109/JSTQE.2016.2630840
IEEE Journal of Selected Topics in Quantum Electronics 23/3 2019-06-06
2018 Antonio Perri, John H. Gaida, Andrea Farina, Fabrizio Preda, Daniele Viola, Matteo Ballottari, Jürgen Hauer, Sandro De Silvestri, Cosimo D’Andrea, Giulio Cerullo, Dario Polli
Time- and frequency-resolved fluorescence with a single TCSPC detector via a Fourier-transform approach
published pages: 2270, ISSN: 1094-4087, DOI: 10.1364/oe.26.002270
Optics Express 26/3 2019-06-06
2018 Francesco Crisafi, Vikas Kumar, Antonio Perri, Marco Marangoni, Giulio Cerullo, Dario Polli
Multimodal nonlinear microscope based on a compact fiber-format laser source
published pages: 135-140, ISSN: 1386-1425, DOI: 10.1016/j.saa.2017.06.055
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 188 2019-06-06
2016 Aurelio Oriana, Julien Réhault, Fabrizio Preda, Dario Polli, Giulio Cerullo
Scanning Fourier transform spectrometer in the visible range based on birefringent wedges
published pages: 1415, ISSN: 1084-7529, DOI: 10.1364/JOSAA.33.001415
Journal of the Optical Society of America A 33/7 2019-06-06
2016 Fabrizio Preda, Vikas Kumar, Francesco Crisafi, Diana Gisell Figueroa del Valle, Giulio Cerullo, Dario Polli
Broadband pump-probe spectroscopy at 20-MHz modulation frequency
published pages: 2970, ISSN: 0146-9592, DOI: 10.1364/OL.41.002970
Optics Letters 41/13 2019-06-06

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