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Opendata, web and dolomites

MRG-GRammar

Massive Reverse Genomics to Decipher Gene Regulatory Grammar

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

MRG-GRammar project word cloud

Explore the words cloud of the MRG-GRammar project. It provides you a very rough idea of what is the project "MRG-GRammar" about.

throughput regulation cell leverage industrial technological rules accelerate model lines decipher generate tree origins yeast substantially organism solutions designing employ tested technologies form mrg gene variations diseases melanogaster ex orthogonal models deciphering systematically designed generating individual base bacteria datasets community sequences edge breakthrough systematic diverse biological synthetic fuel cells genomic naturally strategy nature life natural libraries unbiased accurate predictions biology generation organisms regulatory consequently reference code synthesis algorithm explaining implementing serve vivo ultimate cutting deeper occurring dna synergizes extant entirely extensive algorithms profoundly embryos explore grammar types healthcare iterative interpret personal single mouse human landscapes devise therapeutic multidisciplinary

Project "MRG-GRammar" data sheet

The following table provides information about the project.

Coordinator	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Organization address address: SENATE BUILDING TECHNION CITY city: HAIFA postcode: 32000 website: www.technion.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Project website	http://www.mrg-grammar.eu
Total cost	3˙999˙661 €
EC max contribution	3˙999˙661 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2014-2015-RIA
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-08-01 to 2018-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Organization address address: SENATE BUILDING TECHNION CITY city: HAIFA postcode: 32000 website: www.technion.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (HAIFA)	coordinator	902˙000.00
2	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	850˙848.00
3	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	721˙273.00
4	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	716˙138.00
5	GENOME RESEARCH LIMITED GENOME RESEARCH LIMITED Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE website: http://www.sanger.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	581˙651.00
6	IMPASARA LIMITED IMPASARA LIMITED Organization address address: 43-45 DORSET STREET 2ND FLOOR city: LONDON postcode: W1U 7NA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	189˙000.00
7	AGILENT TECHNOLOGIES LDA ISRAEL LTD AGILENT TECHNOLOGIES LDA ISRAEL LTD Organization address address: 94 EM HAMOSHAVOT ROAD OFER BUSINESS PARK DEKEL BUI 7TH FLOOR city: PETACH TIKVA postcode: 4970602 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (PETACH TIKVA)	participant	38˙750.00

Map

Project objective

MRG-GRammar aims to devise an entirely new strategy for deciphering the regulatory rules of gene regulation. We will leverage Synthetic Biology with cutting-edge DNA synthesis technologies and high-throughput analysis to generate new types of biological datasets that systematically explore all possible regulatory landscapes rather than just the naturally occurring regulatory sequences. The extensive and unbiased nature of these unique datasets will allow us to build new models explaining different aspects of regulatory activity, which will be tested in second-generation libraries, designed based on model predictions. Consequently, through such an iterative process, we expect to make a significant breakthrough in deciphering, and evolving, the regulatory code. Our strategy synergizes four orthogonal objectives that will form a new knowledge base from which the regulatory algorithm can be derived. We will employ our strategy on diverse model organisms from the tree of life, from single cell to whole organism: bacteria, yeast, mouse ex-vivo cells, human cell-lines and finally, whole D. melanogaster and mouse embryos. We expect this multidisciplinary synthetic biology approach to generate a major technological advance, which will provide the community with algorithms that will not only decipher extant natural regulatory code, but also interpret variations leading to a profoundly deeper understanding of the origins of many diseases. We expect our models to also serve as a reference in designing and implementing accurate and more controllable synthetic biology devices, with applications in fuel production, healthcare and other industrial fields. Thus, our ultimate goal is to substantially accelerate the advance of technologies and knowledge related to generating systematic and personal therapeutic solutions based on the analysis of each individual's natural genomic variations.

Deliverables

List of deliverables.
Website	Other	2019-05-31 10:17:19

Take a look to the deliverables list in detail: detailed list of MRG-GRammar deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Edward Vitkin, Oz Solomon, Sharon Sultan, Zohar Yakhini Genome-wide analysis of fitness data and its application to improve metabolic models published pages: , ISSN: 1471-2105, DOI: 10.1186/s12859-018-2341-9	BMC Bioinformatics 19/1	2019-05-29
2018	Eileen E. M. Furlong, Michael Levine Developmental enhancers and chromosome topology published pages: , ISSN: 1095-9203, DOI: 10.1126/science.aau0320	Science	2019-04-04
2017	Lior Levy, Leon Anavy, Oz Solomon, Roni Cohen, Michal Brunwasser-Meirom, Shilo Ohayon, Orna Atar, Sarah Goldberg, Zohar Yakhini, Roee Amit A Synthetic Oligo Library and Sequencing Approach Reveals an Insulation Mechanism Encoded within Bacterial Ïƒ 54 Promoters published pages: 845-858, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.09.063	Cell Reports 21/3	2019-04-03

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The information about "MRG-GRAMMAR" are provided by the European Opendata Portal: CORDIS opendata.

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