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Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Total Cost €


EC-Contrib. €






 ISPIC project word cloud

Explore the words cloud of the ISPIC project. It provides you a very rough idea of what is the project "ISPIC" about.

metastatic    tissues    guided    distal    postoperative    chemotherapy    surgical    basic    monitor    mass    personalised    gene    interactions    latent    effectiveness    platforms    relapse    encapsulated    conjunction    curative    accurate    therapeutic    toxicity    multidisciplinary    transgenic    biomolecules    tumour    immune    micrometastases    directions    efficacy    mouse    accessible    option    profiles    progression    optimise    identification    underlie    observation    image    visualised    forms    initial    limitations    therapy    signatures    encapsulate    models    events    nanoparticle    techniques    disease    surgery    resection    radiotherapy    lack    types    tumours    strategy    components    implementing    intended    biomarkers    ultimately    healthy    immunotherapeutic    function    followed    implies    months    libraries    modulating    combinations    multiplexed    radiation    inability    body    starts    lifetime    platform    protection    reagent    solid    cancer    payload    treatment    aggressive    time    immunotherapy    resides   

Project "ISPIC" data sheet

The following table provides information about the project.


Organization address
address: PLESMANLAAN 1
city: LEIDEN
postcode: 2333 BZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 3˙922˙309 €
 EC max contribution 3˙922˙309 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PERCUROS BV NL (LEIDEN) coordinator 255˙374.00
2    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 680˙998.00
3    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 546˙575.00
5    UNIVERSITETET I BERGEN NO (BERGEN) participant 286˙275.00
8    JENACELL GMBH DE (JENA) participant 249˙216.00
9    MEDRES-MEDICAL RESEARCH GMBH DE (KOLN) participant 249˙216.00
10    TECOBIOSCIENCES GMBH DE (LANDSHUT) participant 249˙216.00
11    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) participant 212˙811.00
13    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 127˙687.00
14    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 127˙687.00


 Project objective

The basic concept of our proposal is to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a lifetime of protection against cancer.


List of deliverables.
Project website live Websites, patent fillings, videos etc. 2020-02-20 16:32:03
All ESRs recruited Other 2020-02-20 16:32:03

Take a look to the deliverables list in detail:  detailed list of ISPIC deliverables.


year authors and title journal last update
List of publications.
2019 Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz
Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles
published pages: 6485-6500, ISSN: 1838-7640, DOI: 10.7150/thno.34429
Theranostics 9/22 2020-02-20
2019 Tamim Abdelaal, Vincent van Unen, Thomas Höllt, Frits Koning, Marcel J.T. Reinders, Ahmed Mahfouz
Predicting Cell Populations in Single Cell Mass Cytometry Data
published pages: 769-781, ISSN: 1552-4922, DOI: 10.1002/cyto.a.23738
Cytometry Part A 95/7 2020-02-20
2019 Na Li, Vincent van Unen, Nannan Guo, Tamim Abdelaal, Antonios Somarakis, Jeroen Eggermont, Ahmed Mahfouz, Susana M. Chuva de Sousa Lopes, Boudewijn P. F. Lelieveldt, Frits Koning
Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01932
Frontiers in Immunology 10 2020-02-20
2018 Di Martino, Piera; Gigliobianco, Maria; Casadidio, Cristina; Censi, Roberta
Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability
published pages: , ISSN: 1999-4923, DOI: 10.20944/PREPRINTS201807.0233.V1
Pharmaceutics, Vol 10, Iss 3, p 134 (2018) 4 2020-02-20
2018 Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte
Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02542-9
Nature Communications 9/1 2020-02-20
2019 Cristina Casadidio, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Siyuan Deng, Roberta Censi, Piera Di Martino
Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science
published pages: 369, ISSN: 1660-3397, DOI: 10.3390/md17060369
Marine Drugs 17/6 2020-02-20
2018 Roberta Censi, Dolores Vargas Peregrina, Giovanna Lacava, Dimitrios Agas, Giulio Lupidi, Maria Sabbieti, Piera Di Martino
Cosmetic Formulation Based on an Açai Extract
published pages: 48, ISSN: 2079-9284, DOI: 10.3390/cosmetics5030048
Cosmetics 5/3 2020-02-20
2019 Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz
A comparison of automatic cell identification methods for single-cell RNA sequencing data
published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-019-1795-z
Genome Biology 20/1 2020-02-20
2019 Michele Genangeli, Annemarie M. M. Heijens, Alice Rustichelli, Noortje Dien Schuit, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Sauro Vittori, Tiffany Porta Siegel, Ron M.A. Heeren
MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment
published pages: 2041-2050, ISSN: 1044-0305, DOI: 10.1007/s13361-019-02265-9
Journal of The American Society for Mass Spectrometry 30/10 2020-02-20
2019 Vinícius Barreto Garcia, Thaís Gomes de Carvalho, Luiz Henrique da Silva Gasparotto, Heloiza Fernanda Oliveira da Silva, Aurigena Antunes de Araújo, Gerlane Coelho Bernardo Guerra, Timo Schomann, Luis J. Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging
published pages: , ISSN: 1931-7573, DOI: 10.1186/s11671-019-2986-y
Nanoscale Research Letters 14/1 2020-02-20
2019 Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp
PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors
published pages: , ISSN: 2051-1426, DOI: 10.1186/s40425-019-0700-3
Journal for ImmunoTherapy of Cancer 7/1 2020-02-20
2018 Jing Zuo, Dapeng Sun, Langping Tu, Yanni Wu, Yinghui Cao, Bin Xue, Youlin Zhang, Yulei Chang, Xiaomin Liu, Xianggui Kong, Wybren Jan Buma, Evert Jan Meijer, Hong Zhang
Precisely Tailoring Upconversion Dynamics via Energy Migration in Core-Shell Nanostructures
published pages: 3054-3058, ISSN: 1433-7851, DOI: 10.1002/anie.201711606
Angewandte Chemie International Edition 57/12 2020-02-20
2018 Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. Löwik
Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase
published pages: 1-7, ISSN: 1368-8375, DOI: 10.1016/j.oraloncology.2017.12.006
Oral Oncology 78 2020-02-20
2019 Michele Genangeli, Ron M. A. Heeren, Tiffany Porta Siegel
Tissue classification by rapid evaporative ionization mass spectrometry (REIMS): comparison between a diathermic knife and CO2 laser sampling on classification performance
published pages: , ISSN: 1618-2642, DOI: 10.1007/s00216-019-02148-8
Analytical and Bioanalytical Chemistry 2020-02-20
2018 Guillaume Beyrend, Koen Stam, Thomas Höllt, Ferry Ossendorp, Ramon Arens
Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations
published pages: 435-442, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2018.10.004
Computational and Structural Biotechnology Journal 16 2020-02-20
2019 Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens Löwik
A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.03097
Frontiers in Immunology 9 2020-02-20
2019 Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda
High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity
published pages: gutjnl-2019-3186, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2019-318672
Gut 2020-02-20
2019 Roberta Censi, Cristina Casadidio, Alessandra Dubbini, Manuela Cortese, Stefania Scuri, Iolanda Grappasonni, Samuel Golob, Dario Vojnovic, Maria Giovanna Sabbieti, Dimitrios Agas, Piera Di Martino
Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections
published pages: 322-333, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.07.006
European Journal of Pharmaceutics and Biopharmaceutics 142 2020-02-20
2018 Iris N. Pardieck, Guillaume Beyrend, Anke Redeker, Ramon Arens
Cytomegalovirus infection and progressive differentiation of effector-memory T cells
published pages: 1554, ISSN: 2046-1402, DOI: 10.12688/f1000research.15753.1
F1000Research 7 2020-02-20
2019 Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino
Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry
published pages: 460622, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2019.460622
Journal of Chromatography A 2020-02-20
2019 Yaima Campos, Amisel Almirall, Gastón Fuentes, Hans L. Bloem, Eric L. Kaijzel, Luis J. Cruz
Tissue Engineering: An Alternative to Repair Cartilage
published pages: 357-373, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0330
Tissue Engineering Part B: Reviews 25/4 2020-02-20
2017 Jian Yang, Yuxue Liu, Yangyang Zhao, Zheng Gong, Meng Zhang, Duanting Yan, Hancheng Zhu, Chunguang Liu, Changshan Xu, Hong Zhang
Ratiometric Afterglow Nanothermometer for Simultaneous in Situ Bioimaging and Local Tissue Temperature Sensing
published pages: 8119-8131, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.7b01958
Chemistry of Materials 29/19 2020-02-20
2018 Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats
published pages: , ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2018.06.008
International Journal of Pharmaceutics 2020-02-20
2018 Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas
Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis
published pages: , ISSN: 1566-5232, DOI: 10.2174/1566523218666180105122626
Current Gene Therapy 17/5 2020-02-20
2018 Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences
published pages: 56-66, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.07.011
Journal of Controlled Release 285 2020-02-20
2018 Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch
Opportunities of bacterial cellulose to treat epithelial tissues
published pages: 808-822, ISSN: 1389-4501, DOI: 10.2174/1389450120666181129092144
Current Drug Targets 20 2020-02-20
2018 Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis
Diverse Functions of Macrophages in Different Tumor Microenvironments
published pages: 5492-5503, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-1367
Cancer Research 78/19 2020-02-20
2019 Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya A. Kasatskaya, Kristin Ladell, James E. McLaren, Evgeny S. Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas Höllt, Olga V Britanova, Jeroen Eggermont, Noel F. C. C. de Miranda, Dmitriy M. Chudakov, David A. Price, Boudewijn P. F. Lelieveldt, Frits Koning
Memory CD4+ T cells are generated in the human fetal intestine
published pages: , ISSN: 1529-2908, DOI: 10.1038/s41590-018-0294-9
Nature Immunology 2020-02-20

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