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TETRA TERMINATED

Autologous Stem Cell Seeded Tissue Engineered Trachea

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TETRA project word cloud

Explore the words cloud of the TETRA project. It provides you a very rough idea of what is the project "TETRA" about.

stent validated 827 maa indication gmp 517 estimate patient hospitalised competitor generate patients subjected dying tracheal rate commercial dossier benefits therapeutic scaffold disease limitations infection tens insertion lives deaths efficacy susceptible 20 limited market repeated organs 11 savings liver reduce plan structural successful length 48 diseases strategies trial eliminate thousands synthetic sme prepare airway pivotal bowel tissues 22 follow surviving scaffolds route led treating million interventions preliminary care inspire severe standard submission risk cells replacements compassionate group atmp tetra surgical quality platform prototype seeded transplants data poorly orphan manufacturing unmet cell life stem conduct accelerated clinical autologous

Project "TETRA" data sheet

The following table provides information about the project.

Coordinator	VIDEREGEN LIMITED Organization address address: INNOVATION CENTRE 1, LIVERPOOL SCIENCE PARK, 131 M ANT city: LIVERPOOL postcode: L3 5TF website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.tetra-h2020.eu/
Total cost	6˙828˙887 €
EC max contribution	6˙828˙884 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-single-stage_RTD
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	VIDEREGEN LIMITED VIDEREGEN LIMITED Organization address address: INNOVATION CENTRE 1, LIVERPOOL SCIENCE PARK, 131 M ANT city: LIVERPOOL postcode: L3 5TF website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	coordinator	1˙563˙340.00
2	TMC PHARMA SERVICES LIMITED TMC PHARMA SERVICES LIMITED Organization address address: Lodge Farm Barn, Elvetham Park Estate city: Hartley Wintney postcode: RG27 8AS website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Hartley Wintney)	participant	1˙127˙146.00
3	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 website: http://www.med.tu.muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	903˙250.00
4	UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST Organization address address: EUSTON ROAD 250 city: LONDON postcode: NW1 2PG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	669˙578.00
5	NHS BLOOD AND TRANSPLANT NHS BLOOD AND TRANSPLANT Organization address address: OAK HOUSE REEDS CRESCENT city: WATFORD postcode: WD24 4QN website: www.nhsbt.nhs.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (WATFORD)	participant	535˙250.00
6	MANCHESTER UNIVERSITY NHS FOUNDATION TRUST MANCHESTER UNIVERSITY NHS FOUNDATION TRUST Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9WL website: www.cmft.nhs.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	483˙512.00
7	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	455˙118.00
8	INSTYTUT GRUZLICY I CHOROB PLUC INSTYTUT GRUZLICY I CHOROB PLUC Organization address address: UL. PLOCKA 26 city: WARSZAWA postcode: 1138 website: www.igichp.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (WARSZAWA)	participant	365˙000.00
9	UNIVERSITA DEGLI STUDI DI BRESCIA UNIVERSITA DEGLI STUDI DI BRESCIA Organization address address: PIAZZA MERCATO 15 city: BRESCIA postcode: 25121 website: www.unibs.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BRESCIA)	participant	346˙266.00
10	CELL THERAPY CATAPULT LIMITED CELL THERAPY CATAPULT LIMITED Organization address address: 12TH FLOOR TOWER WING GUY'S HOSPITAL GREAT MAZE POND city: LONDON postcode: SE1 9RT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	281˙681.00
11	EURAM LIMITED EURAM LIMITED Organization address address: LUCY TOWER STREET TOWER HOUSE city: LINCOLN postcode: LN1 1XW website: www.euram.ltd.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LINCOLN)	participant	65˙496.00
12	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	30˙700.00
13	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	2˙546.00
14	UNIVERSITY HOSPITAL OF SOUTH MANCHESTER NHS FOUNDATION TRUST UNIVERSITY HOSPITAL OF SOUTH MANCHESTER NHS FOUNDATION TRUST Organization address address: SOUTHMOOR ROAD WYTHENSHAWE city: MANCHESTER postcode: M239LT website: www.uhsm.nhs.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	0.00

Map

Project objective

CLINICAL PROBLEM AND UNMET NEED There are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate.

Other therapeutic strategies under development include synthetic tracheal scaffolds seeded with patients own stem cells. Preliminary data show that these scaffolds are poorly integrated and are susceptible to infection.

TETRA PROJECT Our SME-led project will address the limitations of standard clinical care and competitor products under development and will: - Build on our successful compassionate use experience using autologous stem cell seeded scaffold-tracheal transplants in 48 patients - Follow on from our Phase I 4 patient INSPIRE clinical trial which will improve on the clinical prototype used in compassionate use cases - Conduct a 48 patient Phase II pivotal clinical trial to provide robust, quality data with validated GMP manufacturing processes to support an accelerated route to market for commercial exploitation in this orphan indication - Prepare a dossier for MAA submission

BENEFITS Our product, an ATMP, aims to eliminate the need for repeated surgical interventions of high risk and limited efficacy, reduce deaths and improve the quality of life for surviving patients. If treating 20% of the patients with severe structural airway disease, we estimate that in Europe our technology will improve the quality and length of patient lives and result in savings of €517 million per year.

We plan to further develop our platform technology to generate other complex tissues/organs such as bowel and liver replacements for clinical applications which will impact the lives of tens of thousands of patient in the EU with bowel and liver diseases.

Deliverables

List of deliverables.
Project Website	Websites, patent fillings, videos etc.	2019-05-31 18:06:05

Take a look to the deliverables list in detail: detailed list of TETRA deliverables.

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