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SWEETOOLS SIGNED

Smart Biologics: Developing New Tools in Glycobiology

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EC-Contrib. €

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Partnership

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 SWEETOOLS project word cloud

Explore the words cloud of the SWEETOOLS project. It provides you a very rough idea of what is the project "SWEETOOLS" about.

molecule    complexity    sugars    biomolecules    dysfunctions    efficient    deepen    virus    library    enzymes    selective    warhead    decipher    small    chemistry    tools    synthesized    fundamental    designed    multivalent    capability    therapeutics    sugar    vaccines    abnormalities    manipulators    mysteries    outcomes    found    bioorthogonal    templated    understand    protein    contributed    structure    answer    constructs    smart    glycobiology    inhibitors    inhibitory    blockers    reactions    molecular    pathogenesis    effect    fluorogenic    click    functions    screen    entry    severe    interactions    generate    considerably    toward    heteroglycosystems    selectivity    significantly    molecules    showing    combine    create    scaffold    synthetic    methodology    glycans    glycan    glycoconjugates    libraries    events    probes    situ    carbohydrate    biologics    peptide    polyvalent    moieties    construct    merge    ubiquitous    influenza    unveil    structures    appreciation    biological    enzyme    questions    plan    crystal    easily    despite    monitor    realize    kingdoms    glycosylation    class    life    inhibitor    bioconjugate    consist    aided   

Project "SWEETOOLS" data sheet

The following table provides information about the project.

Coordinator
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. 

Organization address
address: FLEMINGOVO NAM. 542/2
city: PRAHA 6
postcode: 16610
website: www.uochb.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 1˙405˙625 €
 EC max contribution 1˙405˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. CZ (PRAHA 6) coordinator 1˙405˙625.00

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 Project objective

Glycans are ubiquitous biomolecules found throughout all kingdoms of life. Early studies contributed considerably to our appreciation of glycan functions by showing that abnormalities in the glycosylation can develop into pathogenesis and severe dysfunctions. Despite the crucial role of sugars in many biological events we still do not have adequate tools to decipher their complexity. To unveil the mysteries in the rapidly emerging field of glycobiology we aim in this proposal to develop new tools that will help us to study and understand these important biomolecules. To realize this, we plan to combine the unique targeting capability of biologics with the inhibitory effect of small molecules into robust constructs with advanced properties. The biological part of the construct will be evolved using synthetic peptide libraries ensuring high selectivity toward particular sugar processing enzymes. The second part of the construct will consist of small molecular inhibitor warhead that will be designed and synthesized based on crystal structure-aided analyses. To merge these two moieties we aim to develop a new target enzyme–templated fluorogenic in situ click chemistry methodology that will enable us to easily monitor and screen whole peptide–small molecule bioconjugate libraries as highly selective inhibitors and manipulators of sugar processing enzymes. In addition, we aim to create new multivalent heteroglycosystems by using bioorthogonal reactions on peptide library scaffold. These structures will enable us to study polyvalent carbohydrate–protein interactions and to generate novel therapeutics such as influenza virus entry blockers. Our goal is to develop a new class of smart bioconjugate probes that will help us to answer fundamental questions in glycobiology. The outcomes of this project will significantly deepen our knowledge of glycoconjugates and in the long term, will allow for the design of efficient vaccines and for the development of selective therapeutics.

 Publications

year authors and title journal last update
List of publications.
2019 Sebastian Joseph Siegl, Juraj Galeta, Rastislav Dzijak, Arcadio Vázquez, Miguel Del Río-Villanueva, Martin Dračínský, Milan Vrabel
An extended approach for the development of fluorogenic trans-cyclooctene-tetrazine cycloadditions
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201800711
ChemBioChem 2019-04-18
2018 Sebastian J. Siegl, Arcadio Vázquez, Rastislav Dzijak, Martin Dračínský, Juraj Galeta, Robert Rampmaier, Blanka Klepetářová, Milan Vrabel
Design and Synthesis of Aza-Bicyclononene Dienophiles for Rapid Fluorogenic Ligations
published pages: 2426-2432, ISSN: 0947-6539, DOI: 10.1002/chem.201705188
Chemistry - A European Journal 24/10 2019-03-18

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