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SWEETOOLS SIGNED

Smart Biologics: Developing New Tools in Glycobiology

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EC-Contrib. €

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Partnership

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 SWEETOOLS project word cloud

Explore the words cloud of the SWEETOOLS project. It provides you a very rough idea of what is the project "SWEETOOLS" about.

despite    ubiquitous    tools    situ    chemistry    bioorthogonal    efficient    deepen    decipher    structure    reactions    merge    selectivity    aided    synthetic    unveil    polyvalent    enzyme    sugars    class    create    fluorogenic    considerably    significantly    molecular    methodology    enzymes    click    consist    biological    designed    realize    peptide    biomolecules    capability    constructs    influenza    easily    glycans    questions    inhibitors    blockers    dysfunctions    understand    biologics    screen    manipulators    smart    inhibitory    moieties    toward    fundamental    monitor    structures    warhead    protein    therapeutics    functions    outcomes    abnormalities    entry    events    generate    probes    library    glycosylation    sugar    molecules    templated    glycobiology    kingdoms    answer    found    scaffold    small    carbohydrate    mysteries    inhibitor    effect    appreciation    glycoconjugates    selective    interactions    showing    molecule    combine    virus    bioconjugate    pathogenesis    crystal    heteroglycosystems    construct    libraries    vaccines    contributed    life    complexity    severe    plan    multivalent    synthesized    glycan   

Project "SWEETOOLS" data sheet

The following table provides information about the project.

Coordinator
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. 

Organization address
address: FLEMINGOVO NAM. 542/2
city: PRAHA 6
postcode: 16610
website: www.uochb.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 1˙405˙625 €
 EC max contribution 1˙405˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. CZ (PRAHA 6) coordinator 1˙405˙625.00

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 Project objective

Glycans are ubiquitous biomolecules found throughout all kingdoms of life. Early studies contributed considerably to our appreciation of glycan functions by showing that abnormalities in the glycosylation can develop into pathogenesis and severe dysfunctions. Despite the crucial role of sugars in many biological events we still do not have adequate tools to decipher their complexity. To unveil the mysteries in the rapidly emerging field of glycobiology we aim in this proposal to develop new tools that will help us to study and understand these important biomolecules. To realize this, we plan to combine the unique targeting capability of biologics with the inhibitory effect of small molecules into robust constructs with advanced properties. The biological part of the construct will be evolved using synthetic peptide libraries ensuring high selectivity toward particular sugar processing enzymes. The second part of the construct will consist of small molecular inhibitor warhead that will be designed and synthesized based on crystal structure-aided analyses. To merge these two moieties we aim to develop a new target enzyme–templated fluorogenic in situ click chemistry methodology that will enable us to easily monitor and screen whole peptide–small molecule bioconjugate libraries as highly selective inhibitors and manipulators of sugar processing enzymes. In addition, we aim to create new multivalent heteroglycosystems by using bioorthogonal reactions on peptide library scaffold. These structures will enable us to study polyvalent carbohydrate–protein interactions and to generate novel therapeutics such as influenza virus entry blockers. Our goal is to develop a new class of smart bioconjugate probes that will help us to answer fundamental questions in glycobiology. The outcomes of this project will significantly deepen our knowledge of glycoconjugates and in the long term, will allow for the design of efficient vaccines and for the development of selective therapeutics.

 Publications

year authors and title journal last update
List of publications.
2019 Sebastian Joseph Siegl, Juraj Galeta, Rastislav Dzijak, Arcadio Vázquez, Miguel Del Río-Villanueva, Martin Dračínský, Milan Vrabel
An extended approach for the development of fluorogenic trans-cyclooctene-tetrazine cycloadditions
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201800711
ChemBioChem 2019-04-18
2018 Sebastian J. Siegl, Arcadio Vázquez, Rastislav Dzijak, Martin Dračínský, Juraj Galeta, Robert Rampmaier, Blanka Klepetářová, Milan Vrabel
Design and Synthesis of Aza-Bicyclononene Dienophiles for Rapid Fluorogenic Ligations
published pages: 2426-2432, ISSN: 0947-6539, DOI: 10.1002/chem.201705188
Chemistry - A European Journal 24/10 2019-03-18

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