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NVS SIGNED

Nano Voltage Sensors

Total Cost €

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EC-Contrib. €

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Partnership

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 NVS project word cloud

Explore the words cloud of the NVS project. It provides you a very rough idea of what is the project "NVS" about.

interactions    afford    cell    confined    particle    excitation    linear    insert    self    healthy    invasively    shift    combined    larger    optimize    tissue    nir    record    individual    voltage    brightness    photon    sensing    brain    spiking    release    sensors    optically    semiconductors    imaging    performance    muscle    membrane    nanorods    physical    generally    diseased    emergent    action    excited    functionalization    hole    electron    potentials    giving    compatibility    ion    signals    opposes    tissues    charges    stores    noise    effect    ratiometric    networks    stokes    fast    synthesis    minimal    quantum    single    stark    deep    channel    separation    tools    ultrafast    electric    sensitivity    dipole    shifts    multiple    origin    affording    detection    lifetime    photoexcited    ions    physiologists    works    absorption    emission    photobleaching    post    afforded    events    spectral    view    threshold    sites    cross    advantages    ca2    hence    targetable    excellent    external    sub    seek    band    neurons    recording    pairs    modulated    microscopy    synaptic    nanoscale    heart    sections    understand    immune    temporal    edges    neuroscientists   

Project "NVS" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://nsbrbiu.wixsite.com/nsbr
 Total cost 3˙497˙553 €
 EC max contribution 3˙497˙553 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 2˙772˙553.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 225˙000.00
3    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) participant 175˙000.00
4    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 175˙000.00
5    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) participant 150˙000.00

Map

 Project objective

To understand how the brain works, tools need to be developed that will allow neuroscientists to investigate how interactions between individual neurons lead to emergent networks. Towards this goal, we will develop targetable voltage sensing nanorods that self-insert into the cell membrane and optically and non-invasively record action potentials at the single particle and nanoscale level, at multiple sites and across a large field-of-view. In semiconductors, absorption and emission band edges are modulated by an external electric field, even more so when optically excited electron-hole pairs are confined, giving rise to the quantum confined Stark effect. The physical origin of this effect is in the separation of photoexcited charges, creating a dipole that opposes the external field. The proposed sensors will optically record action potential with unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift (affording noise-immune ratiometric measurements), fast temporal response, minimal photobleaching, large Stokes shifts, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. The proposed sensors could afford, for example, the recording of pre- and post-synaptic membrane potentials, sub-threshold events, ultrafast spiking, individual ion channel activity, or a release of ions from single Ca2 stores. In addition, deep tissue imaging could be afforded by two photon microscopy and far-field non-linear temporal focusing combined with lifetime imaging. Here we seek to optimize all aspects of the sensors’ synthesis, functionalization, delivery, targeting and detection, in order to provide neuroscientists and physiologists a viable and user-friendly technology that will be generally useful for the study of action potential signals in the brain and in healthy or diseased heart and muscle tissues.

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