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NVS SIGNED

Nano Voltage Sensors

Total Cost €

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EC-Contrib. €

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Partnership

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 NVS project word cloud

Explore the words cloud of the NVS project. It provides you a very rough idea of what is the project "NVS" about.

synthesis    optically    recording    understand    brain    neuroscientists    electron    insert    advantages    excitation    ca2    voltage    stokes    post    temporal    shift    synaptic    cell    noise    detection    emergent    absorption    nanoscale    spectral    sections    giving    excited    neurons    spiking    lifetime    single    membrane    cross    heart    release    shifts    band    confined    sites    ions    deep    separation    stark    dipole    performance    compatibility    opposes    quantum    seek    emission    physical    self    imaging    sensing    stores    networks    semiconductors    edges    ratiometric    larger    brightness    record    works    individual    view    modulated    photoexcited    immune    diseased    microscopy    afforded    minimal    excellent    sensors    sub    particle    photobleaching    potentials    effect    healthy    multiple    nanorods    physiologists    targetable    photon    tissues    combined    charges    ion    signals    affording    threshold    origin    invasively    sensitivity    hence    hole    linear    muscle    nir    electric    tissue    action    functionalization    pairs    external    channel    interactions    generally    fast    ultrafast    afford    tools    optimize    events   

Project "NVS" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://nsbrbiu.wixsite.com/nsbr
 Total cost 3˙497˙553 €
 EC max contribution 3˙497˙553 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 2˙772˙553.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 225˙000.00
3    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) participant 175˙000.00
4    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 175˙000.00
5    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) participant 150˙000.00

Map

 Project objective

To understand how the brain works, tools need to be developed that will allow neuroscientists to investigate how interactions between individual neurons lead to emergent networks. Towards this goal, we will develop targetable voltage sensing nanorods that self-insert into the cell membrane and optically and non-invasively record action potentials at the single particle and nanoscale level, at multiple sites and across a large field-of-view. In semiconductors, absorption and emission band edges are modulated by an external electric field, even more so when optically excited electron-hole pairs are confined, giving rise to the quantum confined Stark effect. The physical origin of this effect is in the separation of photoexcited charges, creating a dipole that opposes the external field. The proposed sensors will optically record action potential with unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift (affording noise-immune ratiometric measurements), fast temporal response, minimal photobleaching, large Stokes shifts, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. The proposed sensors could afford, for example, the recording of pre- and post-synaptic membrane potentials, sub-threshold events, ultrafast spiking, individual ion channel activity, or a release of ions from single Ca2 stores. In addition, deep tissue imaging could be afforded by two photon microscopy and far-field non-linear temporal focusing combined with lifetime imaging. Here we seek to optimize all aspects of the sensors’ synthesis, functionalization, delivery, targeting and detection, in order to provide neuroscientists and physiologists a viable and user-friendly technology that will be generally useful for the study of action potential signals in the brain and in healthy or diseased heart and muscle tissues.

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The information about "NVS" are provided by the European Opendata Portal: CORDIS opendata.

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