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NVS SIGNED

Nano Voltage Sensors

Total Cost €

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EC-Contrib. €

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Partnership

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 NVS project word cloud

Explore the words cloud of the NVS project. It provides you a very rough idea of what is the project "NVS" about.

emergent    quantum    action    sensing    muscle    optimize    nanoscale    understand    single    insert    excellent    post    synaptic    ion    band    works    sites    stokes    afforded    neuroscientists    view    neurons    sub    giving    shifts    external    seek    ions    ultrafast    electron    effect    edges    shift    combined    photoexcited    tools    recording    heart    healthy    diseased    optically    detection    functionalization    temporal    modulated    origin    ratiometric    larger    imaging    dipole    nir    afford    excitation    brightness    synthesis    confined    emission    self    particle    cross    invasively    excited    noise    pairs    deep    spiking    interactions    channel    record    signals    lifetime    voltage    potentials    opposes    sensitivity    hence    electric    brain    multiple    fast    hole    networks    minimal    immune    sensors    absorption    cell    charges    affording    microscopy    stark    physiologists    advantages    sections    photobleaching    nanorods    compatibility    photon    tissues    threshold    ca2    generally    semiconductors    performance    events    linear    targetable    separation    physical    tissue    release    individual    membrane    spectral    stores   

Project "NVS" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://nsbrbiu.wixsite.com/nsbr
 Total cost 3˙497˙553 €
 EC max contribution 3˙497˙553 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 2˙772˙553.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 225˙000.00
3    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) participant 175˙000.00
4    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 175˙000.00
5    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) participant 150˙000.00

Map

 Project objective

To understand how the brain works, tools need to be developed that will allow neuroscientists to investigate how interactions between individual neurons lead to emergent networks. Towards this goal, we will develop targetable voltage sensing nanorods that self-insert into the cell membrane and optically and non-invasively record action potentials at the single particle and nanoscale level, at multiple sites and across a large field-of-view. In semiconductors, absorption and emission band edges are modulated by an external electric field, even more so when optically excited electron-hole pairs are confined, giving rise to the quantum confined Stark effect. The physical origin of this effect is in the separation of photoexcited charges, creating a dipole that opposes the external field. The proposed sensors will optically record action potential with unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift (affording noise-immune ratiometric measurements), fast temporal response, minimal photobleaching, large Stokes shifts, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. The proposed sensors could afford, for example, the recording of pre- and post-synaptic membrane potentials, sub-threshold events, ultrafast spiking, individual ion channel activity, or a release of ions from single Ca2 stores. In addition, deep tissue imaging could be afforded by two photon microscopy and far-field non-linear temporal focusing combined with lifetime imaging. Here we seek to optimize all aspects of the sensors’ synthesis, functionalization, delivery, targeting and detection, in order to provide neuroscientists and physiologists a viable and user-friendly technology that will be generally useful for the study of action potential signals in the brain and in healthy or diseased heart and muscle tissues.

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The information about "NVS" are provided by the European Opendata Portal: CORDIS opendata.

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