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NVS SIGNED

Nano Voltage Sensors

Total Cost €

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EC-Contrib. €

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Partnership

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 NVS project word cloud

Explore the words cloud of the NVS project. It provides you a very rough idea of what is the project "NVS" about.

shifts    view    sensors    temporal    stark    channel    photon    immune    optically    dipole    ion    tissue    minimal    electron    potentials    performance    individual    single    optimize    membrane    muscle    excited    linear    invasively    generally    emergent    sections    detection    sensing    particle    lifetime    hole    absorption    stokes    tissues    self    hence    stores    pairs    microscopy    targetable    seek    ca2    record    understand    insert    compatibility    photobleaching    fast    healthy    spiking    external    ions    voltage    semiconductors    effect    heart    action    sensitivity    imaging    brightness    edges    spectral    interactions    quantum    signals    ultrafast    origin    works    threshold    photoexcited    brain    neurons    emission    shift    excitation    neuroscientists    electric    physiologists    afford    confined    affording    functionalization    advantages    excellent    band    larger    networks    modulated    deep    noise    diseased    nanorods    synthesis    post    ratiometric    charges    tools    release    multiple    separation    physical    sites    events    giving    combined    sub    nir    recording    synaptic    opposes    cross    nanoscale    afforded    cell   

Project "NVS" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://nsbrbiu.wixsite.com/nsbr
 Total cost 3˙497˙553 €
 EC max contribution 3˙497˙553 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 2˙772˙553.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 225˙000.00
3    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) participant 175˙000.00
4    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 175˙000.00
5    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) participant 150˙000.00

Map

 Project objective

To understand how the brain works, tools need to be developed that will allow neuroscientists to investigate how interactions between individual neurons lead to emergent networks. Towards this goal, we will develop targetable voltage sensing nanorods that self-insert into the cell membrane and optically and non-invasively record action potentials at the single particle and nanoscale level, at multiple sites and across a large field-of-view. In semiconductors, absorption and emission band edges are modulated by an external electric field, even more so when optically excited electron-hole pairs are confined, giving rise to the quantum confined Stark effect. The physical origin of this effect is in the separation of photoexcited charges, creating a dipole that opposes the external field. The proposed sensors will optically record action potential with unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift (affording noise-immune ratiometric measurements), fast temporal response, minimal photobleaching, large Stokes shifts, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. The proposed sensors could afford, for example, the recording of pre- and post-synaptic membrane potentials, sub-threshold events, ultrafast spiking, individual ion channel activity, or a release of ions from single Ca2 stores. In addition, deep tissue imaging could be afforded by two photon microscopy and far-field non-linear temporal focusing combined with lifetime imaging. Here we seek to optimize all aspects of the sensors’ synthesis, functionalization, delivery, targeting and detection, in order to provide neuroscientists and physiologists a viable and user-friendly technology that will be generally useful for the study of action potential signals in the brain and in healthy or diseased heart and muscle tissues.

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