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NVS SIGNED

Nano Voltage Sensors

Total Cost €

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EC-Contrib. €

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Partnership

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 NVS project word cloud

Explore the words cloud of the NVS project. It provides you a very rough idea of what is the project "NVS" about.

afforded    potentials    interactions    nanoscale    physiologists    optimize    charges    band    events    self    separation    neuroscientists    electric    deep    diseased    lifetime    multiple    physical    confined    noise    photoexcited    post    ions    muscle    insert    channel    effect    threshold    recording    compatibility    membrane    electron    imaging    heart    microscopy    generally    sections    individual    particle    excitation    origin    cell    record    voltage    modulated    performance    ca2    hence    nanorods    advantages    photobleaching    emission    minimal    excellent    tissues    functionalization    edges    neurons    hole    temporal    view    sensitivity    ratiometric    larger    healthy    opposes    brain    sensors    signals    single    detection    semiconductors    release    sites    cross    spiking    combined    stores    linear    giving    dipole    shift    seek    synaptic    ion    stokes    excited    immune    absorption    targetable    emergent    synthesis    external    affording    sub    action    networks    invasively    ultrafast    photon    spectral    shifts    works    sensing    afford    understand    nir    optically    pairs    fast    quantum    brightness    stark    tissue    tools   

Project "NVS" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://nsbrbiu.wixsite.com/nsbr
 Total cost 3˙497˙553 €
 EC max contribution 3˙497˙553 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 2˙772˙553.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 225˙000.00
3    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) participant 175˙000.00
4    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 175˙000.00
5    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) participant 150˙000.00

Map

 Project objective

To understand how the brain works, tools need to be developed that will allow neuroscientists to investigate how interactions between individual neurons lead to emergent networks. Towards this goal, we will develop targetable voltage sensing nanorods that self-insert into the cell membrane and optically and non-invasively record action potentials at the single particle and nanoscale level, at multiple sites and across a large field-of-view. In semiconductors, absorption and emission band edges are modulated by an external electric field, even more so when optically excited electron-hole pairs are confined, giving rise to the quantum confined Stark effect. The physical origin of this effect is in the separation of photoexcited charges, creating a dipole that opposes the external field. The proposed sensors will optically record action potential with unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift (affording noise-immune ratiometric measurements), fast temporal response, minimal photobleaching, large Stokes shifts, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. The proposed sensors could afford, for example, the recording of pre- and post-synaptic membrane potentials, sub-threshold events, ultrafast spiking, individual ion channel activity, or a release of ions from single Ca2 stores. In addition, deep tissue imaging could be afforded by two photon microscopy and far-field non-linear temporal focusing combined with lifetime imaging. Here we seek to optimize all aspects of the sensors’ synthesis, functionalization, delivery, targeting and detection, in order to provide neuroscientists and physiologists a viable and user-friendly technology that will be generally useful for the study of action potential signals in the brain and in healthy or diseased heart and muscle tissues.

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