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Newcotiana SIGNED

Developing Multipurpose Nicotiana Crops for Molecular Farming using New Plant Breeding Techniques

Total Cost €

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EC-Contrib. €

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Partnership

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 Newcotiana project word cloud

Explore the words cloud of the Newcotiana project. It provides you a very rough idea of what is the project "Newcotiana" about.

smoking    acceptance    valuable    opened    innovative    yield    cultivation    position    quality    communication    food    biomass    genetic    society    closely    science    serious    npbts    npbt    least    beneficial    environments    breeding    relative    genome    health    tools    stability    industrial    stakeholder    proteins    agriculture    refers    contrast    multipurpose    communicated    innovation    garde    plants    nicotiana    biomolecules    tabacum    ethical    transgenes    crops    secondary    benthamiana    decline    assured    tested    transferable    circumventing    species    monitored    alternatives    newcotiana    plant    introduction    close    easily    varieties    biopharmaceuticals    techniques    causing    molecular    avant    revitalize    biofactories    preferred    metabolites    chemicals    rural    sharp    bioproduct    australian    gain    social    group    tissue    perceived    productivity    biosafety    engagement    public    efficient    unprecedented    resilience    create    nutriceutical    toolbox    farming    metabolism    cultivated    traits    carefully    gm    regeneration    distant    heritable    elite    properly    tobacco    precise   

Project "Newcotiana" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://newcotiana.org/
 Total cost 7˙363˙310 €
 EC max contribution 7˙199˙560 € (98%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 702˙581.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 576˙125.00
3    ST GEORGE'S HOSPITAL MEDICAL SCHOOL UK (LONDON) participant 562˙822.00
4    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 495˙513.00
5    AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE IT (ROMA) participant 465˙000.00
6    ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE UK (EGHAM) participant 459˙862.00
7    UNIVERSITAET FUER BODENKULTUR WIEN AT (WIEN) participant 426˙131.00
8    KARLSRUHER INSTITUT FUER TECHNOLOGIE DE (KARLSRUHE) participant 388˙271.00
9    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 371˙321.00
10    VIB VZW BE (ZWIJNAARDE - GENT) participant 359˙475.00
11    JOHN INNES CENTRE UK (NORWICH) participant 349˙792.00
12    IDOASIS 2002 SL ES (MADRID) participant 343˙875.00
13    BIOFACTION KG AT (WIEN) participant 338˙131.00
14    NEUTRAL SUPPLY CHAIN LIMITED UK (SLOUGH, BERKSHIRE) participant 319˙062.00
15    Philip Morris Products S.A. CH (Neuchatel) participant 306˙250.00
16    ASOCIACION EMPRESARIAL DE INVESTIGACION CENTRO TECNOLOGICO NACIONAL AGROALIMENTARIO EXTREMADURA ES (VILLAFRANCO DEL GUADIANA (Badajoz)) participant 292˙107.00
17    LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE DE (Halle) participant 251˙250.00
18    SESDERMA SL ES (RAFELBUNYOL) participant 191˙987.00
19    QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT AU (BRISBANE) participant 0.00

Map

 Project objective

A group of New Plant Breeding Techniques (NPBT) has opened unprecedented opportunities in agriculture. Those NPBTs are at least as efficient and often more precise than previous traditional and GM techniques, while circumventing the introduction of heritable transgenes from distant species in the plant genome. Properly communicated, NPBTs are expected to gain wide acceptance, especially when applied to breeding objectives which are seen as beneficial for the society. A well-perceived objective is Molecular Farming, which refers to the use of plants for the production of valuable biomolecules (e. g. biopharmaceuticals). Cultivated tobacco (Nicotiana tabacum) and its close Australian relative Nicotiana benthamiana, are preferred species in Molecular Farming due to their favourable features: non-food crops, easy tissue regeneration, high productivity, rich secondary metabolism and availability of genetic tools. In sharp contrast, traditional tobacco cultivation is in serious decline in the EU, causing serious social problems in many rural areas. NEWCOTIANA aims to revitalize those areas by breeding efficient Nicotiana biofactories of high-value non-smoking products as alternatives for traditional tobacco crops. NEWCOTIANA will develop the most advanced tobacco NPBTs toolbox, easily transferable to other plants. This will position EU in the avant-garde of breeding innovation. This toolbox will be used to create elite multipurpose Nicotiana varieties improved in product-specific traits (bioproduct quality, stability and yield), next to more general traits as biomass, resilience and biosafety. The “Newcotiana” varieties will be carefully tested in relevant pre-industrial environments for the production of end-value chemicals, namely proteins and metabolites for health and nutriceutical use. Ethical, social and legal aspects will be closely monitored and public and stakeholder engagement will be assured using innovative science communication methodologies.

 Deliverables

List of deliverables.
Initial Report on Regulation and Biosafety updates Documents, reports 2019-10-31 11:03:43
Communication Plan and Gender Action Plan Documents, reports 2019-10-31 11:03:46
PacBio sequencing and assembly of N. benthaminana genome Other 2019-10-31 11:03:44
Dissemination Plan Documents, reports 2019-10-31 11:03:49
Development of Apollo web based genome browser for PacBio N. benthamiana genome assembly Websites, patent fillings, videos etc. 2019-10-31 11:03:47
Initial report on Stakeholder information of NPBTs and Molecular Farming Documents, reports 2019-10-31 11:03:46
Collection of editing enzymes with compared efficiencies and predictive model Documents, reports 2019-10-31 11:03:41

Take a look to the deliverables list in detail:  detailed list of Newcotiana deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Junjie Tan; Fei Zhang; Daniel Karcher; Ralph Bock
Engineering of high-precision base editors for site-specific single nucleotide replacement
published pages: , ISSN: 2041-1723, DOI: 10.5281/zenodo.2586572
Nature Communications 10 1 2019-08-29
2019 Marilise Nogueira, Eugenia M.A. Enfissi, Ralf Welsch, Peter Beyer, Matias D. Zurbriggen, Paul D. Fraser
Construction of a fusion enzyme for astaxanthin formation and its characterisation in microbial and plant hosts: A new tool for engineering ketocarotenoids
published pages: 243-252, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.12.006
Metabolic Engineering 52 2019-08-29
2018 Matthijs Hoelscher, Nadine Tiller, Audrey Y.-H. Teh, Guo-Zhang Wu, Julian K-C. Ma, Ralph Bock
High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves
published pages: 357-370, ISSN: 0167-4412, DOI: 10.1007/s11103-018-0744-7
Plant Molecular Biology 97/4-5 2019-08-29
2019 Joan Miquel Bernabé‐Orts, Iván Casas‐Rodrigo, Eugenio G. Minguet, Viola Landolfi, Victor Garcia‐Carpintero, Silvia Gianoglio, Marta Vázquez‐Vilar, Antonio Granell, Diego Orzaez
Assessment of Cas12a‐mediated gene editing efficiency in plants
published pages: , ISSN: 1467-7644, DOI: 10.1111/pbi.13113
Plant Biotechnology Journal 2019-08-05
2019 Philippe V. Jutras, Friederike Grosse‐Holz, Farnusch Kaschani, Markus Kaiser, Dominique Michaud, Renier A.L. Hoorn
Activity‐based proteomics reveals nine target proteases for the recombinant protein‐stabilizing inhibitor Sl CYS 8 in Nicotiana benthamiana
published pages: , ISSN: 1467-7644, DOI: 10.1111/pbi.13092
Plant Biotechnology Journal 2019-08-05
2019 Lei Pei, Markus Schmidt
Novel biotechnological approaches to produce biological compounds: challenges and opportunities for science communication
published pages: 43-47, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2018.08.012
Current Opinion in Biotechnology 56 2019-08-05
2019 Stefan Schillberg, Nicole Raven, Holger Spiegel, Stefan Rasche, Matthias Buntru
Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins
published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2019.00720
Frontiers in Plant Science 10 2019-09-05

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The information about "NEWCOTIANA" are provided by the European Opendata Portal: CORDIS opendata.

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