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Newcotiana SIGNED

Developing Multipurpose Nicotiana Crops for Molecular Farming using New Plant Breeding Techniques

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

Newcotiana project word cloud

Explore the words cloud of the Newcotiana project. It provides you a very rough idea of what is the project "Newcotiana" about.

tabacum closely least precise carefully causing newcotiana crops resilience garde close communicated tobacco relative efficient quality genome stability toolbox biofactories properly innovation monitored cultivated alternatives decline industrial chemicals biosafety biopharmaceuticals cultivation gm npbt metabolism nicotiana opened breeding unprecedented food serious tested perceived revitalize heritable plant bioproduct nutriceutical agriculture contrast varieties biomolecules secondary acceptance ethical rural preferred public proteins elite health biomass assured distant easily innovative stakeholder productivity valuable environments plants techniques science engagement avant beneficial create refers smoking yield position introduction traits transgenes australian group molecular sharp transferable society tools farming tissue regeneration social communication benthamiana npbts genetic multipurpose species gain metabolites circumventing

Project "Newcotiana" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://newcotiana.org/
Total cost	7˙363˙310 €
EC max contribution	7˙199˙560 € (98%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-NMBP-BIO-2017
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	702˙581.00
2	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	576˙125.00
3	ST GEORGE'S HOSPITAL MEDICAL SCHOOL ST GEORGE'S HOSPITAL MEDICAL SCHOOL Organization address address: CRANMER TERRACE city: LONDON postcode: SW17 0RE website: http://www.sgul.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	562˙822.00
4	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	495˙513.00
5	AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE Organization address address: LUNGOTEVERE GRANDE AMMIRAGLIO THAON DI REVEL 76 city: ROMA postcode: 196 website: http://www.enea.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	465˙000.00
6	ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE Organization address address: EGHAM HILL UNIVERSITY OF LONDON city: EGHAM postcode: TW20 0EX website: http://www.rhul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EGHAM)	participant	459˙862.00
7	UNIVERSITAET FUER BODENKULTUR WIEN UNIVERSITAET FUER BODENKULTUR WIEN Organization address address: GREGOR MENDEL STRASSE 33 city: WIEN postcode: 1180 website: www.boku.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	426˙131.00
8	KARLSRUHER INSTITUT FUER TECHNOLOGIE KARLSRUHER INSTITUT FUER TECHNOLOGIE Organization address address: KAISERSTRASSE 12 city: KARLSRUHE postcode: 76131 website: www.kit.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KARLSRUHE)	participant	388˙271.00
9	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	371˙321.00
10	VIB VZW VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	359˙475.00
11	JOHN INNES CENTRE JOHN INNES CENTRE Organization address address: NORWICH RESEARCH PARK COLNEY city: NORWICH postcode: NR4 7UH website: www.jic.bbsrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORWICH)	participant	349˙792.00
12	IDOASIS 2002 SL IDOASIS 2002 SL Organization address address: C/ TELLEZ, 25 2-1 city: MADRID postcode: 28007 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	343˙875.00
13	BIOFACTION KG BIOFACTION KG Organization address address: KUNDMANNGASSE 39/12 city: WIEN postcode: 1030 website: www.biofaction.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	338˙131.00
14	NEUTRAL SUPPLY CHAIN LIMITED NEUTRAL SUPPLY CHAIN LIMITED Organization address address: 337 BATH ROAD city: SLOUGH, BERKSHIRE postcode: SL1 5PR website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SLOUGH, BERKSHIRE)	participant	319˙062.00
15	Philip Morris Products S.A. Philip Morris Products S.A. Organization address address: Quai Jeanrenaud 56 city: Neuchatel postcode: 2000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Neuchatel)	participant	306˙250.00
16	ASOCIACION EMPRESARIAL DE INVESTIGACION CENTRO TECNOLOGICO NACIONAL AGROALIMENTARIO EXTREMADURA ASOCIACION EMPRESARIAL DE INVESTIGACION CENTRO TECNOLOGICO NACIONAL AGROALIMENTARIO EXTREMADURA Organization address address: CTRA VILLAFRANCO A BALBOA KM 1,2 city: VILLAFRANCO DEL GUADIANA (Badajoz) postcode: 6195 website: www.ctaex.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VILLAFRANCO DEL GUADIANA (Badajoz))	participant	292˙107.00
17	LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE Organization address address: Weinberg 3 city: Halle postcode: 6120 website: www.ipb-halle.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Halle)	participant	251˙250.00
18	SESDERMA SL SESDERMA SL Organization address address: CALLE MASSAMAGRELL 5 POLIGONO INDUSTRIAL RAFELBUNYOL city: RAFELBUNYOL postcode: 46138 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (RAFELBUNYOL)	participant	191˙987.00
19	QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT Organization address address: GEORGE STREET 2 city: BRISBANE postcode: 4001 website: www.qut.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (BRISBANE)	participant	0.00

Map

Project objective

A group of New Plant Breeding Techniques (NPBT) has opened unprecedented opportunities in agriculture. Those NPBTs are at least as efficient and often more precise than previous traditional and GM techniques, while circumventing the introduction of heritable transgenes from distant species in the plant genome. Properly communicated, NPBTs are expected to gain wide acceptance, especially when applied to breeding objectives which are seen as beneficial for the society. A well-perceived objective is Molecular Farming, which refers to the use of plants for the production of valuable biomolecules (e. g. biopharmaceuticals). Cultivated tobacco (Nicotiana tabacum) and its close Australian relative Nicotiana benthamiana, are preferred species in Molecular Farming due to their favourable features: non-food crops, easy tissue regeneration, high productivity, rich secondary metabolism and availability of genetic tools. In sharp contrast, traditional tobacco cultivation is in serious decline in the EU, causing serious social problems in many rural areas. NEWCOTIANA aims to revitalize those areas by breeding efficient Nicotiana biofactories of high-value non-smoking products as alternatives for traditional tobacco crops. NEWCOTIANA will develop the most advanced tobacco NPBTs toolbox, easily transferable to other plants. This will position EU in the avant-garde of breeding innovation. This toolbox will be used to create elite multipurpose Nicotiana varieties improved in product-specific traits (bioproduct quality, stability and yield), next to more general traits as biomass, resilience and biosafety. The “Newcotiana” varieties will be carefully tested in relevant pre-industrial environments for the production of end-value chemicals, namely proteins and metabolites for health and nutriceutical use. Ethical, social and legal aspects will be closely monitored and public and stakeholder engagement will be assured using innovative science communication methodologies.

Deliverables

List of deliverables.
Initial Report on Regulation and Biosafety updates	Documents, reports	2019-10-31 11:03:43
Communication Plan and Gender Action Plan	Documents, reports	2019-10-31 11:03:46
PacBio sequencing and assembly of N. benthaminana genome	Other	2019-10-31 11:03:44
Dissemination Plan	Documents, reports	2019-10-31 11:03:49
Development of Apollo web based genome browser for PacBio N. benthamiana genome assembly	Websites, patent fillings, videos etc.	2019-10-31 11:03:47
Initial report on Stakeholder information of NPBTs and Molecular Farming	Documents, reports	2019-10-31 11:03:46
Collection of editing enzymes with compared efficiencies and predictive model	Documents, reports	2019-10-31 11:03:41

Take a look to the deliverables list in detail: detailed list of Newcotiana deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Junjie Tan; Fei Zhang; Daniel Karcher; Ralph Bock Engineering of high-precision base editors for site-specific single nucleotide replacement published pages: , ISSN: 2041-1723, DOI: 10.5281/zenodo.2586572	Nature Communications 10 1	2019-08-29
2019	Marilise Nogueira, Eugenia M.A. Enfissi, Ralf Welsch, Peter Beyer, Matias D. Zurbriggen, Paul D. Fraser Construction of a fusion enzyme for astaxanthin formation and its characterisation in microbial and plant hosts: A new tool for engineering ketocarotenoids published pages: 243-252, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.12.006	Metabolic Engineering 52	2019-08-29
2018	Matthijs Hoelscher, Nadine Tiller, Audrey Y.-H. Teh, Guo-Zhang Wu, Julian K-C. Ma, Ralph Bock High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves published pages: 357-370, ISSN: 0167-4412, DOI: 10.1007/s11103-018-0744-7	Plant Molecular Biology 97/4-5	2019-08-29
2019	Joan Miquel BernabÃ©â€Orts, IvÃ¡n Casasâ€Rodrigo, Eugenio G. Minguet, Viola Landolfi, Victor Garciaâ€Carpintero, Silvia Gianoglio, Marta VÃ¡zquezâ€Vilar, Antonio Granell, Diego Orzaez Assessment of Cas12aâ€mediated gene editing efficiency in plants published pages: , ISSN: 1467-7644, DOI: 10.1111/pbi.13113	Plant Biotechnology Journal	2019-08-05
2019	Philippe V. Jutras, Friederike Grosseâ€Holz, Farnusch Kaschani, Markus Kaiser, Dominique Michaud, Renier A.L. Hoorn Activityâ€based proteomics reveals nine target proteases for the recombinant proteinâ€stabilizing inhibitor Sl CYS 8 in Nicotiana benthamiana published pages: , ISSN: 1467-7644, DOI: 10.1111/pbi.13092	Plant Biotechnology Journal	2019-08-05
2019	Lei Pei, Markus Schmidt Novel biotechnological approaches to produce biological compounds: challenges and opportunities for science communication published pages: 43-47, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2018.08.012	Current Opinion in Biotechnology 56	2019-08-05
2019	Stefan Schillberg, Nicole Raven, Holger Spiegel, Stefan Rasche, Matthias Buntru Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2019.00720	Frontiers in Plant Science 10	2019-09-05

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The information about "NEWCOTIANA" are provided by the European Opendata Portal: CORDIS opendata.

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