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PALEoRIDER SIGNED

Human health and migration in prehistory

Total Cost €

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EC-Contrib. €

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Partnership

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 PALEoRIDER project word cloud

Explore the words cloud of the PALEoRIDER project. It provides you a very rough idea of what is the project "PALEoRIDER" about.

evolution    disposal    sequencing    stone    basal    recent    3rd    75    technologies    central    ancient    appearing    steppes    intriguingly    contemporaneous    explanation    introgression    human    upheavals    capture    attested    innovative    preserved    explore    mobility    explicit    attractive    plague    climatic    bc    survive    ago    replacements    metal    though    individuals    paleo    trading    age    causative    agent    temporal    groups    societal    demise    periods    permits    europeans    genetic    turnover    hypothesis    immune    record    ideal    relationships    societies    archaeological    pestis    pathogens    ancestry    samples    infectious    extensive    led    assays    genome    form    epidemiological    mobile    alongside    database    investigation    contribution    evolutionary    eastern    detect    explained    dna    humans    vital    diseases    co    variants    characterization    continent    outbreaks    bronze    terminal    shotgun    regions    yersinia    demonstrates    reorganization    modeling    advent    substantial    period    time    track    suggests    framework    loci    coincides    transmissible    fleas    alternative    deep    data    discovered    direct    genomic    networks    strain    population    timing    millennium    bubonic    microbial    pathogen   

Project "PALEoRIDER" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙997˙500.00

Map

 Project objective

Recent ancient DNA studies have discovered a basal form of Yersinia pestis, the causative agent of bubonic plague, in 5,000 year-old individuals from Eastern and Central Europe. Even though this strain is an early form that does likely not survive in fleas and might have been less transmissible, the timing intriguingly coincides with a period of substantial societal changes. The archaeological record of 3rd millennium BC Europe clearly demonstrates the demise of terminal Stone Age and the rise of Bronze Age societies across the continent. This turnover has so far been explained by factors such as climatic changes or the advent of new metal working technologies and associated trading networks, which led to a reorganization of past societies. However, contemporaneous genomic data from ancient Europeans have attested major genetic upheavals in Europe 5,000 years ago, with an introgression of 75% genetic ancestry from mobile groups from the eastern steppes appearing in Central Europe. This substantial contribution suggests that early outbreaks of infectious diseases, such as plague, are a vital alternative explanation for large-scale population replacements and thus an attractive hypothesis for investigation. With well-preserved ancient human samples from relevant time periods and key regions in Europe at our disposal, we have a unique and ideal test case to track evolutionary relationships between the human genome and pathogens through time. We will specifically target an extensive number of variants in human immune-related loci using state-of-the-art DNA capture assays alongside deep sequencing of microbial shotgun and pathogen data, which permits a direct characterization of human-pathogen co-evolution. This unique temporal framework will allow us to detect loci under selection in humans and pathogens, and explore the role of infectious diseases and human mobility in past societies via an innovative paleo-epidemiological database and explicit modeling approaches.

 Publications

year authors and title journal last update
List of publications.
2019 Chuan-Chao Wang, Sabine Reinhold, Alexey Kalmykov, Antje Wissgott, Guido Brandt, Choongwon Jeong, Olivia Cheronet, Matthew Ferry, Eadaoin Harney, Denise Keating, Swapan Mallick, Nadin Rohland, Kristin Stewardson, Anatoly R. Kantorovich, Vladimir E. Maslov, Vladimira G. Petrenko, Vladimir R. Erlikh, Biaslan Ch. Atabiev, Rabadan G. Magomedov, Philipp L. Kohl, Kurt W. Alt, Sandra L. Pichler, Claudia
Ancient human genome-wide data from a 3000-year interval in the Caucasus corresponds with eco-geographic regions
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-08220-8
Nature Communications 10/1 2020-04-11

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