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PALEoRIDER SIGNED

Human health and migration in prehistory

Total Cost €

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EC-Contrib. €

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Partnership

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 PALEoRIDER project word cloud

Explore the words cloud of the PALEoRIDER project. It provides you a very rough idea of what is the project "PALEoRIDER" about.

disposal    individuals    timing    reorganization    data    pathogen    time    diseases    human    advent    detect    recent    explanation    permits    periods    humans    central    strain    shotgun    archaeological    alternative    deep    preserved    ancient    genetic    mobility    turnover    samples    discovered    immune    plague    temporal    intriguingly    fleas    europeans    evolutionary    pestis    genomic    framework    ago    substantial    extensive    climatic    suggests    though    bubonic    population    transmissible    alongside    vital    period    steppes    direct    microbial    regions    assays    attested    explained    contemporaneous    basal    attractive    eastern    technologies    database    metal    millennium    track    mobile    epidemiological    explore    terminal    co    75    continent    demonstrates    modeling    sequencing    ideal    form    introgression    paleo    pathogens    hypothesis    yersinia    explicit    age    trading    variants    stone    appearing    societies    characterization    networks    loci    contribution    replacements    causative    upheavals    societal    survive    genome    bc    groups    ancestry    record    demise    capture    dna    coincides    evolution    outbreaks    bronze    agent    investigation    relationships    3rd    innovative    infectious    led   

Project "PALEoRIDER" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙997˙500.00

Map

 Project objective

Recent ancient DNA studies have discovered a basal form of Yersinia pestis, the causative agent of bubonic plague, in 5,000 year-old individuals from Eastern and Central Europe. Even though this strain is an early form that does likely not survive in fleas and might have been less transmissible, the timing intriguingly coincides with a period of substantial societal changes. The archaeological record of 3rd millennium BC Europe clearly demonstrates the demise of terminal Stone Age and the rise of Bronze Age societies across the continent. This turnover has so far been explained by factors such as climatic changes or the advent of new metal working technologies and associated trading networks, which led to a reorganization of past societies. However, contemporaneous genomic data from ancient Europeans have attested major genetic upheavals in Europe 5,000 years ago, with an introgression of 75% genetic ancestry from mobile groups from the eastern steppes appearing in Central Europe. This substantial contribution suggests that early outbreaks of infectious diseases, such as plague, are a vital alternative explanation for large-scale population replacements and thus an attractive hypothesis for investigation. With well-preserved ancient human samples from relevant time periods and key regions in Europe at our disposal, we have a unique and ideal test case to track evolutionary relationships between the human genome and pathogens through time. We will specifically target an extensive number of variants in human immune-related loci using state-of-the-art DNA capture assays alongside deep sequencing of microbial shotgun and pathogen data, which permits a direct characterization of human-pathogen co-evolution. This unique temporal framework will allow us to detect loci under selection in humans and pathogens, and explore the role of infectious diseases and human mobility in past societies via an innovative paleo-epidemiological database and explicit modeling approaches.

 Publications

year authors and title journal last update
List of publications.
2019 Chuan-Chao Wang, Sabine Reinhold, Alexey Kalmykov, Antje Wissgott, Guido Brandt, Choongwon Jeong, Olivia Cheronet, Matthew Ferry, Eadaoin Harney, Denise Keating, Swapan Mallick, Nadin Rohland, Kristin Stewardson, Anatoly R. Kantorovich, Vladimir E. Maslov, Vladimira G. Petrenko, Vladimir R. Erlikh, Biaslan Ch. Atabiev, Rabadan G. Magomedov, Philipp L. Kohl, Kurt W. Alt, Sandra L. Pichler, Claudia
Ancient human genome-wide data from a 3000-year interval in the Caucasus corresponds with eco-geographic regions
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-08220-8
Nature Communications 10/1 2020-04-11

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