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PALEoRIDER SIGNED

Human health and migration in prehistory

Total Cost €

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EC-Contrib. €

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Partnership

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 PALEoRIDER project word cloud

Explore the words cloud of the PALEoRIDER project. It provides you a very rough idea of what is the project "PALEoRIDER" about.

pathogens    periods    attractive    evolutionary    3rd    vital    technologies    agent    characterization    temporal    bc    plague    societies    population    europeans    deep    demonstrates    immune    pathogen    direct    mobile    fleas    attested    bubonic    hypothesis    humans    discovered    record    extensive    introgression    samples    detect    survive    bronze    genomic    loci    database    basal    explore    millennium    continent    dna    groups    genetic    ancient    contribution    explicit    individuals    intriguingly    climatic    track    suggests    upheavals    capture    investigation    transmissible    sequencing    age    ancestry    paleo    advent    diseases    recent    permits    explained    contemporaneous    metal    ago    demise    strain    modeling    central    disposal    timing    relationships    eastern    led    innovative    75    form    mobility    regions    epidemiological    infectious    appearing    archaeological    pestis    outbreaks    ideal    reorganization    shotgun    assays    steppes    trading    data    co    though    time    turnover    replacements    evolution    human    coincides    stone    societal    alongside    preserved    period    variants    causative    terminal    framework    yersinia    genome    explanation    alternative    microbial    substantial    networks   

Project "PALEoRIDER" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙997˙500.00

Map

 Project objective

Recent ancient DNA studies have discovered a basal form of Yersinia pestis, the causative agent of bubonic plague, in 5,000 year-old individuals from Eastern and Central Europe. Even though this strain is an early form that does likely not survive in fleas and might have been less transmissible, the timing intriguingly coincides with a period of substantial societal changes. The archaeological record of 3rd millennium BC Europe clearly demonstrates the demise of terminal Stone Age and the rise of Bronze Age societies across the continent. This turnover has so far been explained by factors such as climatic changes or the advent of new metal working technologies and associated trading networks, which led to a reorganization of past societies. However, contemporaneous genomic data from ancient Europeans have attested major genetic upheavals in Europe 5,000 years ago, with an introgression of 75% genetic ancestry from mobile groups from the eastern steppes appearing in Central Europe. This substantial contribution suggests that early outbreaks of infectious diseases, such as plague, are a vital alternative explanation for large-scale population replacements and thus an attractive hypothesis for investigation. With well-preserved ancient human samples from relevant time periods and key regions in Europe at our disposal, we have a unique and ideal test case to track evolutionary relationships between the human genome and pathogens through time. We will specifically target an extensive number of variants in human immune-related loci using state-of-the-art DNA capture assays alongside deep sequencing of microbial shotgun and pathogen data, which permits a direct characterization of human-pathogen co-evolution. This unique temporal framework will allow us to detect loci under selection in humans and pathogens, and explore the role of infectious diseases and human mobility in past societies via an innovative paleo-epidemiological database and explicit modeling approaches.

 Publications

year authors and title journal last update
List of publications.
2019 Chuan-Chao Wang, Sabine Reinhold, Alexey Kalmykov, Antje Wissgott, Guido Brandt, Choongwon Jeong, Olivia Cheronet, Matthew Ferry, Eadaoin Harney, Denise Keating, Swapan Mallick, Nadin Rohland, Kristin Stewardson, Anatoly R. Kantorovich, Vladimir E. Maslov, Vladimira G. Petrenko, Vladimir R. Erlikh, Biaslan Ch. Atabiev, Rabadan G. Magomedov, Philipp L. Kohl, Kurt W. Alt, Sandra L. Pichler, Claudia
Ancient human genome-wide data from a 3000-year interval in the Caucasus corresponds with eco-geographic regions
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-08220-8
Nature Communications 10/1 2020-04-11

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