Opendata, web and dolomites

PALEoRIDER SIGNED

Human health and migration in prehistory

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PALEoRIDER project word cloud

Explore the words cloud of the PALEoRIDER project. It provides you a very rough idea of what is the project "PALEoRIDER" about.

epidemiological    ago    diseases    stone    time    explanation    bc    innovative    variants    shotgun    technologies    transmissible    fleas    evolutionary    direct    form    record    relationships    demise    microbial    ancestry    vital    capture    continent    coincides    attractive    explore    explicit    hypothesis    permits    intriguingly    led    data    pathogens    reorganization    basal    explained    investigation    causative    turnover    assays    characterization    networks    human    bubonic    timing    75    survive    3rd    genetic    co    alternative    ancient    paleo    terminal    mobile    groups    population    contemporaneous    outbreaks    bronze    dna    advent    metal    plague    trading    strain    discovered    disposal    agent    age    though    genome    archaeological    modeling    evolution    detect    pathogen    europeans    societal    periods    appearing    steppes    alongside    regions    ideal    attested    sequencing    infectious    mobility    substantial    individuals    upheavals    introgression    database    suggests    humans    millennium    yersinia    samples    track    climatic    eastern    recent    period    preserved    deep    contribution    replacements    demonstrates    temporal    extensive    loci    immune    genomic    pestis    framework    central    societies   

Project "PALEoRIDER" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙997˙500.00

Map

 Project objective

Recent ancient DNA studies have discovered a basal form of Yersinia pestis, the causative agent of bubonic plague, in 5,000 year-old individuals from Eastern and Central Europe. Even though this strain is an early form that does likely not survive in fleas and might have been less transmissible, the timing intriguingly coincides with a period of substantial societal changes. The archaeological record of 3rd millennium BC Europe clearly demonstrates the demise of terminal Stone Age and the rise of Bronze Age societies across the continent. This turnover has so far been explained by factors such as climatic changes or the advent of new metal working technologies and associated trading networks, which led to a reorganization of past societies. However, contemporaneous genomic data from ancient Europeans have attested major genetic upheavals in Europe 5,000 years ago, with an introgression of 75% genetic ancestry from mobile groups from the eastern steppes appearing in Central Europe. This substantial contribution suggests that early outbreaks of infectious diseases, such as plague, are a vital alternative explanation for large-scale population replacements and thus an attractive hypothesis for investigation. With well-preserved ancient human samples from relevant time periods and key regions in Europe at our disposal, we have a unique and ideal test case to track evolutionary relationships between the human genome and pathogens through time. We will specifically target an extensive number of variants in human immune-related loci using state-of-the-art DNA capture assays alongside deep sequencing of microbial shotgun and pathogen data, which permits a direct characterization of human-pathogen co-evolution. This unique temporal framework will allow us to detect loci under selection in humans and pathogens, and explore the role of infectious diseases and human mobility in past societies via an innovative paleo-epidemiological database and explicit modeling approaches.

 Publications

year authors and title journal last update
List of publications.
2019 Chuan-Chao Wang, Sabine Reinhold, Alexey Kalmykov, Antje Wissgott, Guido Brandt, Choongwon Jeong, Olivia Cheronet, Matthew Ferry, Eadaoin Harney, Denise Keating, Swapan Mallick, Nadin Rohland, Kristin Stewardson, Anatoly R. Kantorovich, Vladimir E. Maslov, Vladimira G. Petrenko, Vladimir R. Erlikh, Biaslan Ch. Atabiev, Rabadan G. Magomedov, Philipp L. Kohl, Kurt W. Alt, Sandra L. Pichler, Claudia
Ancient human genome-wide data from a 3000-year interval in the Caucasus corresponds with eco-geographic regions
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-08220-8
Nature Communications 10/1 2020-04-11

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PALEORIDER" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PALEORIDER" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

RODRESET (2019)

Development of novel optogenetic approaches for improving vision in macular degeneration

Read More