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LASER OPTIMAL SIGNED

Laser Ablation: SElectivity and monitoRing for OPTImal tuMor removAL

Total Cost €

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EC-Contrib. €

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Partnership

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 LASER OPTIMAL project word cloud

Explore the words cloud of the LASER OPTIMAL project. It provides you a very rough idea of what is the project "LASER OPTIMAL" about.

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Project "LASER OPTIMAL" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI MILANO 

Organization address
address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133
website: www.polimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙499˙575 €
 EC max contribution 1˙499˙575 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 1˙154˙660.00
2    FONDATION DE COOPERATION SCIENTIFIQUE FR (STRASBOURG) participant 184˙290.00
3    BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE US (DUARTE CA) participant 160˙625.00

Map

 Project objective

Laser Ablation (LA) was extensively investigated for its benefits as minimally invasive thermal therapy for tumor. Despite the LA pros as potential alternative to surgical resection (e.g., use of small fiber optics, echo-endoscope procedures and image-guidance without artifact), the lack of tools for safe and patient-specific treatment restrained its clinical use. LASER OPTIMAL offers a renaissance to LA for the practical management of challenging tumors (e.g., pancreatic cancer): it investigates and develops integrated solutions to achieve an effective and selective LA, that thermally destroys the whole tumor mass, while spearing the normal tissue around. The excellent ambition of LASER OPTIMAL is to achieve and merge: a) biocompatible nanoparticles (BNPs) injected in the tumor, to enhance the selective absorption of laser light; b) patient-specific anatomy of tumor and its surrounding, extracted from clinical images, to retrieve the optimal laser settings; c) accurate, fast and real-time heat-transfer model to simulate laser-tissue-BNPs interaction, predict and visualize the treatment dynamics; d) real-time temperature measurement system to monitor LA effects, account for unpredictable physiological events and tune the settings (closed-loop). The design of ex vivo and in vivo animal tests allows assessing the system performances and driving the possible workflow re-design. Finally, human trials are envisaged to prove the significant impact of the LASER OPTIMAL paradigm. The collaboration of researchers, engineers and clinicians will drive the use of this innovative strategy in clinical routine. The research on the patient-specific system for the mini-invasive tumors removal, and the ground-breaking insights on clinical use of BNPs will strongly impact on EU healthcare system and society, by creating a novel product. This paradigm is also embeddable in existing system of industrial partner, extendable to other procedures, thus able to encourage a dedicated market.

 Publications

year authors and title journal last update
List of publications.
2018 Paola Saccomandi, Alfonso Lapergola, Fabio Longo, Emiliano Schena, Giuseppe Quero
Thermal ablation of pancreatic cancer: A systematic literature review of clinical practice and pre-clinical studies
published pages: 398-418, ISSN: 0265-6736, DOI: 10.1080/02656736.2018.1506165
International Journal of Hyperthermia 35/1 2020-04-24

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