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iNtoPoreAge SIGNED

Assessing transcriptional and nuclear pore aging in age-equivalent and rejuvenated induced neurons from Alzheimer patients

Total Cost €

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EC-Contrib. €

0

Partnership

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 iNtoPoreAge project word cloud

Explore the words cloud of the iNtoPoreAge project. It provides you a very rough idea of what is the project "iNtoPoreAge" about.

scientist    stle    treatable    powerful    dysregulation    reprogramming    am    me    patients    uuml    bonn    innsbruck    understand    researcher    cellular    ipsc    age    nuclear    biology    phenotypically    potentially    technologies    preserves    vital    give    controls    unravel    specialized    establishing    functional    fibroblasts    neuropsychiatric    br    conversion    neuroscience    plan    salk    designed    neuronal    pathogenesis    transport    acquired    independent    university    tenure    imaging    seek    neurodegenerative    initiating    sporadic    live    postdoc    biologist    nucleo    direct    dr    myself    foundation    dependent    protected    cytoplasmic    neurons    bioinformatics    earliest    generate    helped    time    models    accepted    frank    transcriptome    award    edenhofer    trained    gage    ad    unbiased    position    disease    aging    pinpoint    modeling    pore    complete    disorders    rejuvenated    erases    cell    start    phd    mechanisms    training    supervisor    lab    permanent    first    stem    diseases    prof    signatures    alzheimer    track    human    successfully    data   

Project "iNtoPoreAge" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET INNSBRUCK 

Organization address
address: INNRAIN 52
city: INNSBRUCK
postcode: 6020
website: http://www.uibk.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET INNSBRUCK AT (INNSBRUCK) coordinator 178˙156.00

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 Project objective

I am a stem cell biologist specialized on modeling human neurodegenerative diseases. During my PhD with Dr. O. Brüstle (University of Bonn), I was trained in human stem cell and reprogramming technologies working on human models for Alzheimer’s Disease (AD). As a postdoc at the Salk Institute with Dr. F. H. Gage, I acquired and strong foundation in functional neuroscience, nuclear pore biology and systems biology/bioinformatics. My work helped to better understand complex neuropsychiatric disorders, as well as the process of neuronal aging. I could show that direct conversion of human fibroblasts into induced neurons (iN) preserves signatures of cell aging, while iPSC reprogramming erases them. To start my own independent lab, I have accepted a tenure track position at the University of Innsbruck. As an independent scientist, I seek to bring together my recent findings on reprogramming and aging, my permanent interest in AD, and powerful systems biology and bioinformatics to unravel the age-dependent disease-initiating mechanisms of sporadic AD. In this proposal, I, together with my supervisor Prof. Dr. Frank Edenhofer, designed a dedicated research and training plan. In the first aim of the project, I will generate phenotypically old (iN) and rejuvenated (iPSC) neurons from an established set of well-characterized AD patients and controls. Using unbiased transcriptome approaches, the data will help to better understand the impact of neuronal aging on sporadic AD pathogenesis. In a second aim, I will use live-cell imaging approaches to study the age-related dysregulation of nucleo-cytoplasmic transport. The goal is to better understand how cellular aging affects pathogenesis, in order to pinpoint the earliest and potentially most treatable mechanisms involved in AD. This award will enable my research in Innsbruck and give me protected time to successfully complete the proposed research, which is vital for establishing myself as an independent researcher in Europe.

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The information about "INTOPOREAGE" are provided by the European Opendata Portal: CORDIS opendata.

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