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iNtoPoreAge SIGNED

Assessing transcriptional and nuclear pore aging in age-equivalent and rejuvenated induced neurons from Alzheimer patients

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 iNtoPoreAge project word cloud

Explore the words cloud of the iNtoPoreAge project. It provides you a very rough idea of what is the project "iNtoPoreAge" about.

give    neuronal    neuropsychiatric    accepted    functional    data    innsbruck    modeling    rejuvenated    nuclear    neurodegenerative    frank    cytoplasmic    complete    stle    conversion    live    trained    preserves    mechanisms    potentially    stem    dysregulation    phd    acquired    erases    specialized    biology    understand    pore    ipsc    transport    designed    establishing    myself    edenhofer    foundation    bonn    tenure    controls    postdoc    pinpoint    alzheimer    disease    unbiased    track    pathogenesis    scientist    generate    gage    university    award    independent    cellular    start    me    lab    ad    neurons    initiating    patients    plan    fibroblasts    supervisor    diseases    dependent    time    signatures    uuml    technologies    biologist    vital    models    treatable    age    nucleo    aging    cell    bioinformatics    disorders    successfully    am    training    transcriptome    earliest    seek    neuroscience    br    unravel    sporadic    dr    first    human    reprogramming    powerful    imaging    phenotypically    position    salk    permanent    researcher    direct    prof    protected    helped   

Project "iNtoPoreAge" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET INNSBRUCK 

Organization address
address: INNRAIN 52
city: INNSBRUCK
postcode: 6020
website: http://www.uibk.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET INNSBRUCK AT (INNSBRUCK) coordinator 178˙156.00

Map

 Project objective

I am a stem cell biologist specialized on modeling human neurodegenerative diseases. During my PhD with Dr. O. Brüstle (University of Bonn), I was trained in human stem cell and reprogramming technologies working on human models for Alzheimer’s Disease (AD). As a postdoc at the Salk Institute with Dr. F. H. Gage, I acquired and strong foundation in functional neuroscience, nuclear pore biology and systems biology/bioinformatics. My work helped to better understand complex neuropsychiatric disorders, as well as the process of neuronal aging. I could show that direct conversion of human fibroblasts into induced neurons (iN) preserves signatures of cell aging, while iPSC reprogramming erases them. To start my own independent lab, I have accepted a tenure track position at the University of Innsbruck. As an independent scientist, I seek to bring together my recent findings on reprogramming and aging, my permanent interest in AD, and powerful systems biology and bioinformatics to unravel the age-dependent disease-initiating mechanisms of sporadic AD. In this proposal, I, together with my supervisor Prof. Dr. Frank Edenhofer, designed a dedicated research and training plan. In the first aim of the project, I will generate phenotypically old (iN) and rejuvenated (iPSC) neurons from an established set of well-characterized AD patients and controls. Using unbiased transcriptome approaches, the data will help to better understand the impact of neuronal aging on sporadic AD pathogenesis. In a second aim, I will use live-cell imaging approaches to study the age-related dysregulation of nucleo-cytoplasmic transport. The goal is to better understand how cellular aging affects pathogenesis, in order to pinpoint the earliest and potentially most treatable mechanisms involved in AD. This award will enable my research in Innsbruck and give me protected time to successfully complete the proposed research, which is vital for establishing myself as an independent researcher in Europe.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INTOPOREAGE" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INTOPOREAGE" are provided by the European Opendata Portal: CORDIS opendata.

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