I am a stem cell biologist specialized on modeling human neurodegenerative diseases. During my PhD with Dr. O. Brüstle (University of Bonn), I was trained in human stem cell and reprogramming technologies working on human models for Alzheimer’s Disease (AD). As a postdoc at the Salk Institute with Dr. F. H. Gage, I acquired and strong foundation in functional neuroscience, nuclear pore biology and systems biology/bioinformatics. My work helped to better understand complex neuropsychiatric disorders, as well as the process of neuronal aging. I could show that direct conversion of human fibroblasts into induced neurons (iN) preserves signatures of cell aging, while iPSC reprogramming erases them. To start my own independent lab, I have accepted a tenure track position at the University of Innsbruck. As an independent scientist, I seek to bring together my recent findings on reprogramming and aging, my permanent interest in AD, and powerful systems biology and bioinformatics to unravel the age-dependent disease-initiating mechanisms of sporadic AD. In this proposal, I, together with my supervisor Prof. Dr. Frank Edenhofer, designed a dedicated research and training plan. In the first aim of the project, I will generate phenotypically old (iN) and rejuvenated (iPSC) neurons from an established set of well-characterized AD patients and controls. Using unbiased transcriptome approaches, the data will help to better understand the impact of neuronal aging on sporadic AD pathogenesis. In a second aim, I will use live-cell imaging approaches to study the age-related dysregulation of nucleo-cytoplasmic transport. The goal is to better understand how cellular aging affects pathogenesis, in order to pinpoint the earliest and potentially most treatable mechanisms involved in AD. This award will enable my research in Innsbruck and give me protected time to successfully complete the proposed research, which is vital for establishing myself as an independent researcher in Europe.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INTOPOREAGE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "INTOPOREAGE" are provided by the European Opendata Portal: CORDIS opendata.
More projects from the same programme (H2020-EU.1.3.2.)
MultiSeaSpace (2019)
Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.
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No valid XML