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SILICOFCM SIGNED

In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SILICOFCM" data sheet

The following table provides information about the project.

Coordinator
ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO 

Organization address
address: PRVOSLAVA STOJANOVICA STREET 6
city: KRAGUJEVAC
postcode: 34000
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Serbia [RS]
 Total cost 5˙507˙441 €
 EC max contribution 5˙507˙441 € (100%)
 Programme 1. H2020-EU.3.1.5. (Methods and data)
 Code Call H2020-SC1-2017-CNECT-2
 Funding Scheme /RIA
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO RS (KRAGUJEVAC) coordinator 653˙000.00
2    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 604˙090.00
3    UNIVERSITY OF WASHINGTON US (SEATTLE WA) participant 450˙201.00
4    INSTITUT ZA KARDIOVASKULARNE BOLESTI VOJVODINE RS (SREMSKA KAMENICA) participant 445˙750.00
5    ILLINOIS INSTITUTE OF TECHNOLOGY US (CHICAGO IL) participant 417˙750.00
6    UNIVERSITY OF KENT UK (CANTERBURY, KENT) participant 413˙550.00
7    SORBONNE UNIVERSITE FR (PARIS) participant 396˙625.00
8    KLINIKUM DER UNIVERSITAET REGENSBURG DE (REGENSBURG) participant 374˙625.00
9    BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION ES (BARCELONA) participant 342˙375.00
10    SEVEN BRIDGES GENOMICS INC US (CAMBRIDGE MA) participant 339˙375.00
11    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 327˙475.00
12    Steinbeis Advanced Risk Technologies GmbH DE (STUTTGART) participant 278˙750.00
13    PANEPISTIMIO IOANNINON EL (IOANNINA) participant 276˙375.00
14    UNIVERZA V LJUBLJANI SI (LJUBLJANA) participant 187˙500.00

Mappa

 Project objective

According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease or abnormal loading conditions. There are four major classifications of cardiomyopathy: hypertrophic (HCM), dilated (DCM), restrictive (RCM), and arrhythmogenic right ventricular (ARVC). Familial cardiomyopathies (FCM) are most commonly diagnosed, or progress of the disease is monitored, through in vivo imaging, with either echocardiography or, increasingly, cardiac magnetic resonance imaging (MRI). The treatment of symptoms of FCM by established therapies could only in part improve the outcome, but novel therapies need to be developed to affect the disease process and time course more fundamentally. SILICOFCM project will develop in silico computational cloud platform which will integrate from stopped-flow molecular kinetic assays to magnetic resonance imaging of the whole heart, bioinformatics and image processing tools with state of the art computer models with the aim to reduce animal and clinical studies for a new drug development and optimized clinical therapy of FCM. The developed system will be distributed on the cloud platforms in order to achieve efficient data storage and high-performance computing, that can offer end users results in reasonably short time. Academic technical partners IIT, UOI, UL and BSC will be responsible for developing and integration of in silico cloud computational platform with multi-scale cardiac muscle modelling which include experiments on protein mutation in vitro from UNIKENT, UNIFI and UW. Bioinformatics tools will be integrated by US company SBG. Clinical partners UNEW, ICVDV, UPMC and UHREG will do retrospective and prospective studies. SME partner R-Tech will be in charge of regulatory issues and reports and BIOIRC will do the exploitation of the project.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "SILICOFCM" are provided by the European Opendata Portal: CORDIS opendata.

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