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SILICOFCM SIGNED

In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

Total Cost €

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EC-Contrib. €

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Partnership

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 SILICOFCM project word cloud

Explore the words cloud of the SILICOFCM project. It provides you a very rough idea of what is the project "SILICOFCM" about.

protein    restrictive    tools    therapy    arvc    time    molecular    storage    uhreg    uw    coronary    assays    mri    structural    resonance    imaging    unikent    unifi    arrhythmogenic    loading    abnormal    fundamentally    limiting    reduce    myocardium    efficient    drug    academic    muscle    cloud    magnetic    according    hcm    right    clinical    bioinformatics    reports    vitro    computing    therapies    ul    reasonably    silico    upmc    2014    flow    familial    society    kinetic    computer    cardiology    performance    stopped    dilated    experiments    retrospective    symptoms    rcm    mutation    cardiac    ventricular    echocardiography    responsible    models    course    artery    distributed    icvdv    heart    monitored    charge    unew    dcm    optimized    treatment    fcm    guidelines    bsc    integration    image    sbg    progress    computational    either    unexplained    data    disease    hypertrophic    tech    integrate    functional    prospective    regulatory    classifications    outcome    vivo    platform    abnormalities    sme    cardiomyopathies    animal    bioirc    iit    cardiomyopathy    platforms    company    silicofcm    diagnosed    uoi   

Project "SILICOFCM" data sheet

The following table provides information about the project.

Coordinator
ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO 

Organization address
address: PRVOSLAVA STOJANOVICA STREET 6
city: KRAGUJEVAC
postcode: 34000
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Serbia [RS]
 Project website https://silicofcm.eu/
 Total cost 5˙507˙441 €
 EC max contribution 5˙507˙441 € (100%)
 Programme 1. H2020-EU.3.1.5. (Methods and data)
 Code Call H2020-SC1-2017-CNECT-2
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO RS (KRAGUJEVAC) coordinator 653˙000.00
2    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 604˙090.00
3    UNIVERSITY OF WASHINGTON US (SEATTLE WA) participant 450˙201.00
4    INSTITUT ZA KARDIOVASKULARNE BOLESTI VOJVODINE RS (SREMSKA KAMENICA) participant 445˙750.00
5    Illinois Institute of Technology US (CHICAGO IL) participant 417˙750.00
6    UNIVERSITY OF KENT UK (CANTERBURY, KENT) participant 413˙550.00
7    SORBONNE UNIVERSITE FR (PARIS) participant 396˙625.00
8    KLINIKUM DER UNIVERSITAET REGENSBURG DE (REGENSBURG) participant 374˙625.00
9    BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION ES (BARCELONA) participant 342˙375.00
10    SEVEN BRIDGES GENOMICS INC US (CAMBRIDGE MA) participant 339˙375.00
11    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 327˙475.00
12    STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH DE (STUTTGART) participant 278˙750.00
13    PANEPISTIMIO IOANNINON EL (IOANNINA) participant 276˙375.00
14    UNIVERZA V LJUBLJANI SI (LJUBLJANA) participant 187˙500.00

Map

 Project objective

According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease or abnormal loading conditions. There are four major classifications of cardiomyopathy: hypertrophic (HCM), dilated (DCM), restrictive (RCM), and arrhythmogenic right ventricular (ARVC). Familial cardiomyopathies (FCM) are most commonly diagnosed, or progress of the disease is monitored, through in vivo imaging, with either echocardiography or, increasingly, cardiac magnetic resonance imaging (MRI). The treatment of symptoms of FCM by established therapies could only in part improve the outcome, but novel therapies need to be developed to affect the disease process and time course more fundamentally. SILICOFCM project will develop in silico computational cloud platform which will integrate from stopped-flow molecular kinetic assays to magnetic resonance imaging of the whole heart, bioinformatics and image processing tools with state of the art computer models with the aim to reduce animal and clinical studies for a new drug development and optimized clinical therapy of FCM. The developed system will be distributed on the cloud platforms in order to achieve efficient data storage and high-performance computing, that can offer end users results in reasonably short time. Academic technical partners IIT, UOI, UL and BSC will be responsible for developing and integration of in silico cloud computational platform with multi-scale cardiac muscle modelling which include experiments on protein mutation in vitro from UNIKENT, UNIFI and UW. Bioinformatics tools will be integrated by US company SBG. Clinical partners UNEW, ICVDV, UPMC and UHREG will do retrospective and prospective studies. SME partner R-Tech will be in charge of regulatory issues and reports and BIOIRC will do the exploitation of the project.

 Deliverables

List of deliverables.
SILICOFCM flyers Other 2019-07-23 15:45:40
Imaging acquisition data Documents, reports 2019-07-23 15:45:34
SILICOFCM Cloud platform Documents, reports 2019-07-23 15:45:48
Project Website Other 2019-07-23 15:45:37
Project videos Other 2019-07-23 15:45:45
Road map on Business Model v1 Documents, reports 2019-07-23 15:45:29
Software: Upgrade FE simulation Documents, reports 2019-07-23 15:45:45
SILICOFCM Reference Architecture Documents, reports 2019-07-23 15:45:33

Take a look to the deliverables list in detail:  detailed list of SILICOFCM deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Chloe A. Johnson, Jonathan Walklate, Marina Svicevic, Srboljub M. Mijailovich, Carlos Vera, Anastasia Karabina, Leslie A. Leinwand, Michael A. Geeves
The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles
published pages: , ISSN: , DOI:
BioRxiv 2019-08-29
2019 Sarah Charman, Nduka Okwose, Gregory Maniatopoulos, Sara Graziadio, Tamara Metzler, Helen Banks, Luke Vale, Guy A MacGowan, Petar M Seferović, Ahmet Fuat, Christi Deaton, Jonathan Mant, Richard F D Hobbs, Djordje G Jakovljevic
Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: qualitative study
published pages: e028122, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2018-028122
BMJ Open 9/4 2019-08-29
2019 J. Walklate, Zoltan Ujfalusi, Vincent Behrens, Edward J. King, Michael A. Geeves
A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins
published pages: 113338, ISSN: 0003-2697, DOI: 10.1016/j.ab.2019.06.009
Analytical Biochemistry 581 2019-08-29
2019 Nicoletta Piroddi, E. Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Beatrice Scellini, Paul J.M. Wijnker, Vasco Sequiera, Dennis Dooijes, Cristobal dos Remedios, Saskia Schlossarek, Man Ching Leung, Andrew Messer, Douglas G. Ward, Annibale Biggeri, Chiara Tesi, Lucie Carrier, Charles S. Redwood, Steven B. Marston, Jolanda van der Velden, Corrado Poggesi
The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM
published pages: 18-29, ISSN: 0022-1295, DOI: 10.1085/jgp.201812160
The Journal of General Physiology 151/1 2019-08-05
2018 Miljan Milosevic, Dusica Stojanovic, Vladimir Simic, Bogdan Milicevic, Andjela Radisavljevic, Petar Uskokovic, Milos Kojic
A Computational Model for Drug Release from PLGA Implant
published pages: 2416, ISSN: 1996-1944, DOI: 10.3390/ma11122416
Materials 11/12 2019-08-05
2019 Milos Parovic, Nduka C. Okwose, Kristian Bailey, Lazar Velicki, Zlatko Fras, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic
NT‐proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure
published pages: 449-454, ISSN: 2055-5822, DOI: 10.1002/ehf2.12424
ESC Heart Failure 6/2 2019-08-05
2019 Giulia Vitale, Erica Lazzeri, Irene Costantini, Francesco Giardini, Giacomo Mazzamuto, Claudia Crocini, Nicoletta Piroddi, Beatrice Scellini, Manuel J. Pioner, Cecilia Ferrantini, Chiara Tesi, Francesco S. Pavone, Leonardo Sacconi, Corrado Poggesi
Advanced Morpho-Functional Analysis on Ventricular and Atrial Tissue Reveals Cross-Bridge Kinetics Alterations and Sarcomere Energetic Impairment in Hcm Patients
published pages: 29a, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.11.198
Biophysical Journal 116/3 2019-08-05
2019 Carlos D Vera, Chloe A Johnson, Jonathan Walklate, Arjun Adhikari, Zoltan Ujfalusi, Marina Svicevic, Srba M Mijailovich, Ariana Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Leslie A. Leinwand, Michael A. Geeves
Pediatric and adult-onset HCM mutations in the myosin motor domain have similar properties
published pages: , ISSN: , DOI:
2019-08-05
2019 Srboljub M. Mijailovich, Momcilo Prodanovic, Lazar Vasovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier
Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments
published pages: 116a, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.11.654
Biophysical Journal 116/3 2019-08-05
2019 Samuel Sossalla, Christine Meindl, Marcus Fischer, Matthias Lubnow, Thomas Müller, Lars S. Maier
Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock
published pages: , ISSN: 1941-7640, DOI: 10.1161/circinterventions.118.007425
Circulation: Cardiovascular Interventions 12/2 2019-08-05
2019 M. Kojic, M. Milosevic, V. Simic, V. Geroski, A. Ziemys, N. Filipovic, M. Ferrari
Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue
published pages: 288-304, ISSN: 0010-4825, DOI: 10.1016/j.compbiomed.2019.03.023
Computers in Biology and Medicine 108 2019-08-05
2019 Aaron Koshy, Nduka C. Okwose, David Nunan, Anet Toms, David A. Brodie, Patrick Doherty, Petar Seferovic, Arsen Ristic, Lazar Velicki, Nenad Filipovic, Dejana Popovic, Jane Skinner, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic
Association between heart rate variability and haemodynamic response to exercise in chronic heart failure
published pages: 77-82, ISSN: 1401-7431, DOI: 10.1080/14017431.2019.1590629
Scandinavian Cardiovascular Journal 53/2 2019-08-05
2019 Srboljub M. Mijailovich, Boban Stojanovic, Djordje Nedic, Marina Svicevic, Michael A. Geeves, Thomas C. Irving, Henk L. Granzier
Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity
published pages: 680-704, ISSN: 0022-1295, DOI: 10.1085/jgp.201812165
The Journal of General Physiology 151/5 2019-08-05
2019 Federica Sacco
Quantification of the influence of detailed endocardial structures on human cardiac haemodynamics and electrophysiology using HPC
published pages: , ISSN: , DOI:
2019-08-30
2019 Xin Gao, Djordje G. Jakovljevic, Daniel A. Beard
Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging
published pages: , ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.06.026
Biophysical Journal 2019-08-30

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