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CLAUSTRUM SIGNED

Optical interrogation of the claustrum from synapses to behavior

Total Cost €

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EC-Contrib. €

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Partnership

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 CLAUSTRUM project word cloud

Explore the words cloud of the CLAUSTRUM project. It provides you a very rough idea of what is the project "CLAUSTRUM" about.

genetic    anatomy    electrophysiological    complete    neocortical    paucity    claustrum    experiments    fundamental    understand    probe    tools    region    hindered    manipulating    indicating    input    generate    function    regions    nucleus    neurons    anatomical    buried    possibility    drive    connectivity    sensory    integration    enigmatic    effect    brain    direct    play    perception    questions    claustral    feedback    behaviour    output    precise    monitoring    difficult    record    manner    multisensory    neocortex    striatum    indicates    animal    nearly    how    integrating    decisions    manipulate    harness    exerts    reciprocal    behavioural    suggested    optical    subcortical    relationships    lack    inputs    corticoclaustral    interconnectivity    inability    bilateral    none    influence    selectively    causal    integrate    distinctive    multiple    claustrocortical    battery    rectify    dense    data    modern    stimulation    motor    neuroscience    thin    environment    structure   

Project "CLAUSTRUM" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 1˙500˙000.00

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 Project objective

How does the brain integrate inputs from the environment to generate perception and drive decisions? An enigmatic brain region called the claustrum has been suggested to play a role by integrating inputs from multiple brain regions. There is strong interconnectivity between claustrum and nearly every neocortical brain region, indicating that it exerts widespread influence on brain function. However, approaches to specifically record from or manipulate activity in the claustrum have been hindered by the inability to target it selectively. This has been difficult due to the anatomy of the claustrum: it is a long, thin bilateral nucleus buried between the neocortex and the striatum. This proposal aims to understand the role of the claustrum in multisensory integration and behaviour by developing new approaches for monitoring and manipulating the activity of the claustrum. We will harness recent advances in electrophysiological, genetic, optical, and behavioural tools to probe its connectivity, activity, and function in a precise manner. Understanding the role of the claustrum in brain function will provide fundamental insight into information processing in the neocortex, which is a major goal in neuroscience. The claustrum is unique because of its dense reciprocal connectivity with neocortex but nearly complete lack of direct subcortical sensory input. This particular anatomical structure indicates the possibility of a unique function, but none has been observed yet. This proposal will rectify the paucity of data on this distinctive structure by applying a battery of modern tools to address the function of the claustrum. Experiments will address the following key questions:

1. How are claustrocortical inputs integrated and what is the effect of corticoclaustral feedback?

2. What is the activity of claustral neurons during sensory stimulation and motor output?

3. What are the causal relationships between claustrum activity and animal behaviour?

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The information about "CLAUSTRUM" are provided by the European Opendata Portal: CORDIS opendata.

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