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CLAUSTRUM SIGNED

Optical interrogation of the claustrum from synapses to behavior

Total Cost €

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EC-Contrib. €

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Partnership

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 CLAUSTRUM project word cloud

Explore the words cloud of the CLAUSTRUM project. It provides you a very rough idea of what is the project "CLAUSTRUM" about.

bilateral    how    modern    neocortex    function    inputs    record    stimulation    possibility    hindered    lack    relationships    difficult    probe    neuroscience    causal    motor    paucity    sensory    distinctive    generate    region    striatum    reciprocal    enigmatic    brain    buried    nucleus    inability    claustral    precise    manner    output    drive    behavioural    manipulating    integrating    integrate    multisensory    genetic    decisions    behaviour    thin    play    anatomy    questions    multiple    neocortical    regions    exerts    optical    influence    claustrocortical    structure    environment    nearly    rectify    suggested    dense    perception    tools    interconnectivity    input    claustrum    corticoclaustral    feedback    animal    electrophysiological    subcortical    anatomical    fundamental    harness    understand    monitoring    indicates    effect    indicating    data    neurons    selectively    connectivity    experiments    integration    complete    none    battery    manipulate    direct   

Project "CLAUSTRUM" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 1˙500˙000.00

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 Project objective

How does the brain integrate inputs from the environment to generate perception and drive decisions? An enigmatic brain region called the claustrum has been suggested to play a role by integrating inputs from multiple brain regions. There is strong interconnectivity between claustrum and nearly every neocortical brain region, indicating that it exerts widespread influence on brain function. However, approaches to specifically record from or manipulate activity in the claustrum have been hindered by the inability to target it selectively. This has been difficult due to the anatomy of the claustrum: it is a long, thin bilateral nucleus buried between the neocortex and the striatum. This proposal aims to understand the role of the claustrum in multisensory integration and behaviour by developing new approaches for monitoring and manipulating the activity of the claustrum. We will harness recent advances in electrophysiological, genetic, optical, and behavioural tools to probe its connectivity, activity, and function in a precise manner. Understanding the role of the claustrum in brain function will provide fundamental insight into information processing in the neocortex, which is a major goal in neuroscience. The claustrum is unique because of its dense reciprocal connectivity with neocortex but nearly complete lack of direct subcortical sensory input. This particular anatomical structure indicates the possibility of a unique function, but none has been observed yet. This proposal will rectify the paucity of data on this distinctive structure by applying a battery of modern tools to address the function of the claustrum. Experiments will address the following key questions:

1. How are claustrocortical inputs integrated and what is the effect of corticoclaustral feedback?

2. What is the activity of claustral neurons during sensory stimulation and motor output?

3. What are the causal relationships between claustrum activity and animal behaviour?

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The information about "CLAUSTRUM" are provided by the European Opendata Portal: CORDIS opendata.

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