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CLAUSTRUM SIGNED

Optical interrogation of the claustrum from synapses to behavior

Total Cost €

EC-Contrib. €

Partnership

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CLAUSTRUM project word cloud

Explore the words cloud of the CLAUSTRUM project. It provides you a very rough idea of what is the project "CLAUSTRUM" about.

structure electrophysiological causal selectively integration behavioural direct integrate probe effect monitoring manner complete indicates multiple optical integrating inability inputs function record rectify motor anatomy environment neocortical how nearly hindered animal lack brain suggested decisions neocortex generate bilateral behaviour distinctive striatum claustrum stimulation regions paucity subcortical experiments play neurons genetic reciprocal multisensory enigmatic perception output drive understand data dense precise anatomical sensory difficult indicating nucleus questions manipulating fundamental influence possibility interconnectivity neuroscience region exerts modern relationships manipulate battery connectivity none feedback buried thin tools corticoclaustral claustrocortical claustral harness input

Project "CLAUSTRUM" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2019-STG
Funding Scheme	ERC-STG
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2024-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	coordinator	1˙500˙000.00

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Project objective

How does the brain integrate inputs from the environment to generate perception and drive decisions? An enigmatic brain region called the claustrum has been suggested to play a role by integrating inputs from multiple brain regions. There is strong interconnectivity between claustrum and nearly every neocortical brain region, indicating that it exerts widespread influence on brain function. However, approaches to specifically record from or manipulate activity in the claustrum have been hindered by the inability to target it selectively. This has been difficult due to the anatomy of the claustrum: it is a long, thin bilateral nucleus buried between the neocortex and the striatum. This proposal aims to understand the role of the claustrum in multisensory integration and behaviour by developing new approaches for monitoring and manipulating the activity of the claustrum. We will harness recent advances in electrophysiological, genetic, optical, and behavioural tools to probe its connectivity, activity, and function in a precise manner. Understanding the role of the claustrum in brain function will provide fundamental insight into information processing in the neocortex, which is a major goal in neuroscience. The claustrum is unique because of its dense reciprocal connectivity with neocortex but nearly complete lack of direct subcortical sensory input. This particular anatomical structure indicates the possibility of a unique function, but none has been observed yet. This proposal will rectify the paucity of data on this distinctive structure by applying a battery of modern tools to address the function of the claustrum. Experiments will address the following key questions:

1. How are claustrocortical inputs integrated and what is the effect of corticoclaustral feedback?

2. What is the activity of claustral neurons during sensory stimulation and motor output?

3. What are the causal relationships between claustrum activity and animal behaviour?

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The information about "CLAUSTRUM" are provided by the European Opendata Portal: CORDIS opendata.