Explore the words cloud of the ASSIMILES project. It provides you a very rough idea of what is the project "ASSIMILES" about.
The following table provides information about the project.
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙199˙145 €|
|EC max contribution||2˙199˙145 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-09-01 to 2021-08-31|
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|1||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||coordinator||2˙199˙145.00|
A technological revolution is currently taking place making it possible to noninvasively study metabolism in mammals (incl. humans) in vivo with unprecedented temporal and spatial resolution. Central to these developments is the phenomenon of hyperpolarization, which transiently enhances the magnetic resonance (MR) signals so much that real-time metabolic imaging and spectroscopy becomes possible. The first clinical translation of hyperpolarization MR technology has recently been demonstrated with prostate cancer patients. I have played an active role in these exciting developments, through design and construction of hyperpolarization MR setups that are defining the cutting-edge for in vivo preclinical metabolic studies. However, important obstacles still exist for the technology to fulfill its enormous potential. With this highly interdisciplinary proposal, I will overcome the principal drawbacks of current hyperpolarization technology, namely: 1) A limited time window for hyperpolarized MR detection; 2) The conventional use of potentially toxic polarizing agents; 3) The necessity to use supra-physiological doses of metabolic substrates to reach detectable MR signal I will develop a novel hyperpolarization instrument making use of photoexcited compounds as polarizing agents to produce hyperpolarized solutions containing exclusively endogenous compounds. It will become possible to deliver hyperpolarized solutions in a quasi-continuous manner, permitting infusion of physiological doses and greatly increasing sensitivity. I will also use a complementary isotope imaging technique, the so-called CryoNanoSIMS (developed at my institution over the last year), which can image isotopic distributions in frozen tissue sections and reveal the localization of injected substrates and their metabolites with subcellular spatial resolution. Case studies will include liver and brain cancer mouse models. This work is pioneering and will create a new frontier in molecular imaging.
|year||authors and title||journal||last update|
Yuhei Takado, Tian Cheng, Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Bernard Lanz, Mor Mishkovsky, Sylvain Lengacher, Arnaud Comment
Hyperpolarized 13 C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Bloodâ€“Brain Barrier in the Cerebral Uptake and Metabolism of l -Lactate in Vivo
published pages: 2554-2562, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00066
|ACS Chemical Neuroscience 9/11||2020-01-22|
Irene Marco-Rius, Tian Cheng, Adam P. Gaunt, Saket Patel, Felix Kreis, Andrea Capozzi, Alan J. Wright, Kevin M. Brindle, Olivier Ouari, Arnaud Comment
Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13 C MR with Photosensitive Metabolic Substrates
published pages: 14455-14463, ISSN: 0002-7863, DOI: 10.1021/jacs.8b09326
|Journal of the American Chemical Society 140/43||2020-01-22|
Irene Marcoâ€Rius and Arnaud Comment
In Vivo Hyperpolarized 13C MRS and MRI Applications
published pages: 167-177, ISSN: , DOI:
|eMagRes Volume 7||2020-01-22|
Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Andrea Capozzi, Juerg Schwitter, Rolf Gruetter, Matthew E. Merritt, Arnaud Comment
Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced nonpersistent radicals
published pages: 2451-2459, ISSN: 0740-3194, DOI: 10.1002/mrm.27122
|Magnetic Resonance in Medicine 79/5||2020-01-22|
Andrea Capozzi, Saket Patel, Christine Pepke Gunnarsson, Irene Marco-Rius, Arnaud Comment, Magnus Karlsson, Mathilde H. Lerche, Olivier Ouari, Jan Henrik Ardenkjaer-Larsen
Efficient Hyperpolarization of U- 13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals
published pages: 1334-1339, ISSN: 1433-7851, DOI: 10.1002/anie.201810522
|Angewandte Chemie International Edition 58/5||2020-01-22|
Andrea Capozzi, Tian Cheng, Giovanni Boero, Christophe Roussel, Arnaud Comment
Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates
published pages: 15757, ISSN: 2041-1723, DOI: 10.1038/ncomms15757
|Nature Communications 8||2020-01-22|
Mor Mishkovsky, Brian Anderson, Magnus Karlsson, Mathilde H. Lerche, A. Dean Sherry, Rolf Gruetter, Zoltan Kovacs, Arnaud Comment
Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12086-z
|Scientific Reports 7/1||2020-01-22|
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