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ASSIMILES SIGNED

Advanced Spectroscopy and Spectrometry for Imaging Metabolism using Isotopically-Labeled Endogenous Substrates

Total Cost €

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EC-Contrib. €

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Partnership

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 ASSIMILES project word cloud

Explore the words cloud of the ASSIMILES project. It provides you a very rough idea of what is the project "ASSIMILES" about.

detection    metabolites    endogenous    becomes    fulfill    transiently    noninvasively    create    frozen    instrument    metabolic    brain    isotopic    tissue    infusion    vivo    window    toxic    conventional    hyperpolarized    mouse    frontier    resonance    containing    drawbacks    signals    phenomenon    limited    exclusively    sensitivity    demonstrated    permitting    agents    prostate    isotope    detectable    exist    construction    spatial    place    obstacles    technological    unprecedented    temporal    photoexcited    revolution    models    cutting    physiological    potentially    enormous    pioneering    complementary    sections    reveal    compounds    quasi    humans    liver    metabolism    first    overcome    time    molecular    translation    mammals    resolution    supra    hyperpolarization    solutions    injected    doses    active    technique    substrates    principal    edge    cryonanosims    manner    central    continuous    cancer    spectroscopy    incl    distributions    enhances    imaging    mr    played    setups    image    magnetic    last    polarizing    subcellular    patients    preclinical    signal    interdisciplinary    localization    clinical   

Project "ASSIMILES" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://crukcambridgecentre.org.uk/users/arnaud-comment
 Total cost 2˙199˙145 €
 EC max contribution 2˙199˙145 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 2˙199˙145.00

Map

 Project objective

A technological revolution is currently taking place making it possible to noninvasively study metabolism in mammals (incl. humans) in vivo with unprecedented temporal and spatial resolution. Central to these developments is the phenomenon of hyperpolarization, which transiently enhances the magnetic resonance (MR) signals so much that real-time metabolic imaging and spectroscopy becomes possible. The first clinical translation of hyperpolarization MR technology has recently been demonstrated with prostate cancer patients. I have played an active role in these exciting developments, through design and construction of hyperpolarization MR setups that are defining the cutting-edge for in vivo preclinical metabolic studies. However, important obstacles still exist for the technology to fulfill its enormous potential. With this highly interdisciplinary proposal, I will overcome the principal drawbacks of current hyperpolarization technology, namely: 1) A limited time window for hyperpolarized MR detection; 2) The conventional use of potentially toxic polarizing agents; 3) The necessity to use supra-physiological doses of metabolic substrates to reach detectable MR signal I will develop a novel hyperpolarization instrument making use of photoexcited compounds as polarizing agents to produce hyperpolarized solutions containing exclusively endogenous compounds. It will become possible to deliver hyperpolarized solutions in a quasi-continuous manner, permitting infusion of physiological doses and greatly increasing sensitivity. I will also use a complementary isotope imaging technique, the so-called CryoNanoSIMS (developed at my institution over the last year), which can image isotopic distributions in frozen tissue sections and reveal the localization of injected substrates and their metabolites with subcellular spatial resolution. Case studies will include liver and brain cancer mouse models. This work is pioneering and will create a new frontier in molecular imaging.

 Publications

year authors and title journal last update
List of publications.
2018 Yuhei Takado, Tian Cheng, Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Bernard Lanz, Mor Mishkovsky, Sylvain Lengacher, Arnaud Comment
Hyperpolarized 13 C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of l -Lactate in Vivo
published pages: 2554-2562, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00066
ACS Chemical Neuroscience 9/11 2020-01-22
2018 Irene Marco-Rius, Tian Cheng, Adam P. Gaunt, Saket Patel, Felix Kreis, Andrea Capozzi, Alan J. Wright, Kevin M. Brindle, Olivier Ouari, Arnaud Comment
Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13 C MR with Photosensitive Metabolic Substrates
published pages: 14455-14463, ISSN: 0002-7863, DOI: 10.1021/jacs.8b09326
Journal of the American Chemical Society 140/43 2020-01-22
2018 Irene Marco‐Rius and Arnaud Comment
In Vivo Hyperpolarized 13C MRS and MRI Applications
published pages: 167-177, ISSN: , DOI:
eMagRes Volume 7 2020-01-22
2018 Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Andrea Capozzi, Juerg Schwitter, Rolf Gruetter, Matthew E. Merritt, Arnaud Comment
Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced nonpersistent radicals
published pages: 2451-2459, ISSN: 0740-3194, DOI: 10.1002/mrm.27122
Magnetic Resonance in Medicine 79/5 2020-01-22
2019 Andrea Capozzi, Saket Patel, Christine Pepke Gunnarsson, Irene Marco-Rius, Arnaud Comment, Magnus Karlsson, Mathilde H. Lerche, Olivier Ouari, Jan Henrik Ardenkjaer-Larsen
Efficient Hyperpolarization of U- 13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals
published pages: 1334-1339, ISSN: 1433-7851, DOI: 10.1002/anie.201810522
Angewandte Chemie International Edition 58/5 2020-01-22
2017 Andrea Capozzi, Tian Cheng, Giovanni Boero, Christophe Roussel, Arnaud Comment
Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates
published pages: 15757, ISSN: 2041-1723, DOI: 10.1038/ncomms15757
Nature Communications 8 2020-01-22
2017 Mor Mishkovsky, Brian Anderson, Magnus Karlsson, Mathilde H. Lerche, A. Dean Sherry, Rolf Gruetter, Zoltan Kovacs, Arnaud Comment
Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12086-z
Scientific Reports 7/1 2020-01-22

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