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HBM4EU SIGNED

European Human Biomonitoring Initiative

Total Cost €

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EC-Contrib. €

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Partnership

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Project "HBM4EU" data sheet

The following table provides information about the project.

Coordinator
UMWELTBUNDESAMT 

Organization address
address: Woerlitzer Platz 1
city: DESSAU-ROSSLAU
postcode: 6844
website: www.uba.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://hbm4eu.eu
 Total cost 74˙169˙889 €
 EC max contribution 49˙933˙776 € (67%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme COFUND-EJP
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UMWELTBUNDESAMT DE (DESSAU-ROSSLAU) coordinator 10˙535˙680.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 5˙807˙866.00
3    VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V. BE (MOL) participant 4˙525˙900.00
4    RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU NL (BILTHOVEN) participant 3˙862˙579.00
5    INSTITUTO DE SALUD CARLOS III ES (MADRID) participant 3˙025˙889.00
6    Masarykova univerzita CZ (BRNO STRED) participant 1˙864˙456.00
7    ARISTOTELIO PANEPISTIMIO THESSALONIKIS EL (THESSALONIKI) participant 1˙767˙052.00
8    Department of Health UK (Leeds) participant 1˙703˙344.00
9    EUROPEAN ENVIRONMENT AGENCY DK (COPENHAGEN K) participant 1˙528˙355.00
10    TERVEYDEN JA HYVINVOINNIN LAITOS FI (HELSINKI) participant 1˙301˙133.00
11    REGION HOVEDSTADEN DK (HILLEROD) participant 1˙289˙859.00
12    ISTITUTO SUPERIORE DI SANITA IT (ROMA) participant 1˙158˙993.00
13    NATURVARDSVERKET SE (STOCKHOLM) participant 1˙132˙140.00
14    UMWELTBUNDESAMT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (UBA GMBH) AT (WIEN) participant 1˙130˙451.00
15    DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DK (KOBENHAVN) participant 1˙070˙625.00
16    FOLKEHELSEINSTITUTTET NO (OSLO) participant 840˙631.00
17    INSTITUT JOZEF STEFAN SI (LJUBLJANA) participant 703˙529.00
18    INSTITUTO NACIONAL DE SAUDE DR. RICARDO JORGE PT (LISBOA) participant 693˙077.00
19    HASKOLI ISLANDS IS (REYKJAVIK) participant 690˙171.00
20    TYOTERVEYSLAITOS FI (HELSINKI) participant 683˙419.00
21    SCIENSANO BE (ELSENE) participant 585˙212.00
22    Ministry of Health of the Republic of Cyprus CY (Nicosia) participant 405˙069.00
23    INSTYTUT MEDYCYNY PRACY IMIENIA PROF. DRA MED. JERZEGO NOFERA W LODZI PL (LODZ) participant 396˙441.00
24    FUNDACAO PARA A CIENCIA E A TECNOLOGIA PT (LISBOA) participant 393˙572.00
25    SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE SK (BRATISLAVA) participant 328˙784.00
26    NACIONALNI INSTITUT ZA JAVNO ZDRAVJE SI (LJUBLJANA) participant 277˙650.00
27    LABORATOIRE NATIONAL DE SANTE LU (DUDELANGE) participant 275˙212.00
28    HRVATSKI ZAVOD ZA JAVNO ZDRAVSTVO HR (ZAGREB) participant 267˙213.00
29    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) participant 263˙348.00
30    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 245˙362.00
31    MINISTRY OF HEALTH IL (JERUSALEM) participant 193˙789.00
32    HEALTH SERVICE EXECUTIVE HSE IE (NAAS) participant 160˙460.00
33    RIGAS STRADINA UNIVERSITATE LV (RIGA) participant 159˙830.00
34    NACIONALINE VISUOMENES SVEIKATOS PRIEZIUROS LABORATORIJA LT (VILNIUS) participant 158˙974.00
35    URAD VEREJNEHO ZDRAVOTNICTVA SLOVENSKEJ REPUBLIKY SK (BRATISLAVA) participant 133˙214.00
36    VALSTS IZGLITIBAS ATTISTIBAS AGENTURA LV (RIGA) participant 121˙095.00
37    NEMZETI NEPEGESZSEGUGYI KOZPONT HU (BUDAPEST) participant 108˙742.00
38    J.Z.U. INSTITUT ZA JAVNO ZDRAVJE NA REPUBLIKA SEVERNA MAKEDONIJA SKOPJE MK (SKOPJE) participant 79˙705.00
39    MOKSLO INOVACIJU IR TECHNOLOGIJU AGENTURA LT (VILNIUS) participant 46˙011.00
40    TERVISEAMET EE (TALLINN) participant 17˙318.00
41    MINISTERO DELLA SALUTE IT (ROMA) participant 1˙606.00
42    INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE BE (BRUXELLES) participant 0.00
43    SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT CH (Basel) participant 0.00

Map

 Project objective

The overarching goal of the European Human Biomonitoring Initiative (HBM4EU) is to generate knowledge to inform the safe management of chemicals and so protect human health. We will use human biomonitoring to understand human exposure to chemicals and resulting health impacts and will communicate with policy makers to ensure that our results are exploited in the design of new chemicals policies and the evaluation of existing measures. Key objectives include: • Harmonizing procedures for human biomonitoring across 26 countries, to provide policy makers with comparable data on human internal exposure to chemicals and mixtures of chemicals at EU level; • Linking data on internal exposure to chemicals to aggregate external exposure and identifying exposure pathways and upstream sources. Information on exposure pathways is critical to the design of targeted policy measures to reduce exposure; • Generating scientific evidence on the causal links between human exposure to chemicals and negative health outcomes; and • Adapting chemical risk assessment methodologies to use human biomonitoring data and account for the contribution of multiple external exposure pathways to the total chemical body burden. We will achieve these objectives by harmonizing human biomonitoring initiatives in 26 countries, drawing on existing expertise and building new capacities. By establishing National Hubs in each country to coordinate activities, we will create a robust Human Biomonitoring Platform at European level. This initiative contributes directly to the improvement of health and well-being for all age groups, by investigating how exposure to chemicals affects the health of different groups, such as children, pregnant women, foetuses and workers. We will also investigate how factor such as behavior, lifestyle and socio-economic status influence internal exposure to chemicals across the EU population. This knowledge will support policy action to reduce chemical exposure and protect health.

 Deliverables

List of deliverables.
Report on approaches to identify mixture health effects (UBRUN) Documents, reports 2020-03-25 16:16:45
2020 Programme of training activities, materials and capacity building mechanisms (RUMC) Documents, reports 2020-03-25 16:16:45
2nd review of training methods (RUMC) Documents, reports 2020-03-25 16:16:44
Report information needs from policy makers translated in terms of functionality of HBM mixture information Documents, reports 2020-03-25 16:16:44
Second report on biobank activities (KI) Documents, reports 2020-03-25 16:16:44
Second report on targeted new fieldwork and results Documents, reports 2020-03-25 16:16:44
2020 Strategy for the communication and dissemination of HBM4EU results Documents, reports 2020-03-25 16:16:44
Scoping documents for 2020 Documents, reports 2020-03-25 16:16:44
2019 Programme of training activities, materials and capacity building mechanisms (RUMC) Documents, reports 2020-03-25 16:16:44
1st Report on analytical results and new methods development (IPA) Documents, reports 2020-03-25 16:16:44
Report on estimation of relevant tissue and biological fluid doses of 1st set of priority compounds in the EU population using refined PBTK modeling Documents, reports 2020-03-25 16:16:44
Sustainability of HBM4EU in the future and related operational architecture concept: first report Documents, reports 2020-03-25 16:16:44
Revised set of key indicators (DOMG) Documents, reports 2020-03-25 16:16:44
Identified gaps for the establishment of AOPs and required studies Documents, reports 2020-03-25 16:16:44
2nd substance-group specific risk assessment Documents, reports 2020-03-25 16:16:44
1st update on the report on opportunities and obstacles of combining HBM and health studies, availability of health studies and administrative registers and guidelines Documents, reports 2020-03-25 16:16:44
2nd-priorisation-Report on survey design: Study protocols, SOPs and Guidelines, tailored and transferred questionnaires for recruitment and sampling Documents, reports 2020-03-25 16:16:44
Report Outline and workplan for the joint survey on HBM mixtures (IRAS) Documents, reports 2020-03-25 16:16:44
Databases of candidate laboratories for the 2nd prioritization round of substances (ULPGC) Documents, reports 2020-03-25 16:16:44
2nd material for communication to participants, including informed consent Documents, reports 2020-03-25 16:16:44
1st Phased Action Plan for translation of HBM results into policy advise, measures and suggestions for further research at general level (UAntwerpen) Documents, reports 2020-03-25 16:16:44
Initial report on occupational studies Documents, reports 2020-03-25 16:16:44
Statistical Analysis Plan for each substance group for 1st set of substances (ISGlobal) Documents, reports 2020-03-25 16:16:42
1st Report on stakeholder consultation and mapping of needs Documents, reports 2020-03-25 16:16:42
HBM4EU website Websites, patent fillings, videos etc. 2020-03-25 16:16:42
Scoping paper on the development of an indicator on chemical exposure in the European population Documents, reports 2020-03-25 16:16:42
Review paper on PBTK/D models for the 1st set of priority compounds Documents, reports 2020-03-25 16:16:43
2019 Strategy for the communication and dissemination of HBM4EU results Documents, reports 2020-03-25 16:16:43
Report on ongoing activities and existing data and data gaps for the 2nd prioritised substances including a list of metadata that can be uploaded in IPCheM (FMUL) Documents, reports 2020-03-25 16:16:43
Inventory of available samples and data collected from existing cohorts and preliminary results on exposure-response associations for 1st list of priority substances Documents, reports 2020-03-25 16:16:43
Statistical Analysis Plan for each substance group for 2nd set of substances (ISGlobal) Documents, reports 2020-03-25 16:16:44
The Quality Assurance/Quality Control Scheme in HBM4EU project (IPASUM) Documents, reports 2020-03-25 16:16:42
List of biomarkers for the 1st set of prioritized substances (UGR) Documents, reports 2020-03-25 16:16:43
Report real-life exposure profiles from re-analysis of existing HBM mixture data Documents, reports 2020-03-25 16:16:43
Report on biological half-lives of 1st set of priority compounds Documents, reports 2020-03-25 16:16:42
Report on the optimal methodology for exposure reconstruction from HBM data Documents, reports 2020-03-25 16:16:43
2017 Strategy for the communication and dissemination of HBM4EU results Documents, reports 2020-03-25 16:16:43
Report on ongoing activities and existing data and data gaps for the 1st prioritised substances including a list of metadata that can be uploaded in IPCheM (FMUL) Documents, reports 2020-03-25 16:16:43
Prioritised list of biomarkers, matrices and analytical methods for the 1st prioritization round of substances Documents, reports 2020-03-25 16:16:43
Report on available biomarkers of effect of proven utility in human epidemiological studies for the 1st set of prioritised substances (UGR) Documents, reports 2020-03-25 16:16:42
Legal and Ethics Policy document (UCPH) Documents, reports 2020-03-25 16:16:43
Templates for the submission of urgent requests for new information, one for EU policy makers and one for national policy makers (ANSES) Documents, reports 2020-03-25 16:16:43
Prioritisation strategy and criteria (ANSES) Documents, reports 2020-03-25 16:16:42
Report on results of the selected biomarker of effect (UGR) Documents, reports 2020-03-25 16:16:42
List of criteria for selecting cohort studies Documents, reports 2020-03-25 16:16:42
Strategy and SOPs for human sample exchange, including ethical demands (IBMT) Documents, reports 2020-03-25 16:16:42
Second list of prioritised substances and proposed CGLs for 2019-2021 (ANSES) Documents, reports 2020-03-25 16:16:42
First report on targeted new fieldwork study results Documents, reports 2020-03-25 16:16:43
Description of national programmes Documents, reports 2020-03-25 16:16:43
Report on opportunities and obstacles of combining HBM and health studies, availability of health studies and administrative registers and guidelines Documents, reports 2020-03-25 16:16:43
Databases of candidate laboratories for the 1st prioritization round of substances (ULPGC) Documents, reports 2020-03-25 16:16:42
1st review of training methods (RUMC) Documents, reports 2020-03-25 16:16:44
Criteria for prioritisation of biomarkers of effect (UGR) Documents, reports 2020-03-25 16:16:42
Initial report on strategies adopted to align studies across Europe and preliminary results Documents, reports 2020-03-25 16:16:43
2018 Strategy for the communication and dissemination of HBM4EU results Documents, reports 2020-03-25 16:16:43
Establishment of Stakeholder Forum and Advisory Board Documents, reports 2020-03-25 16:16:42
1st substance-group specific derivation of EU-wide health based guidance values Documents, reports 2020-03-25 16:16:42
First set of key indicators (LNE Department) Documents, reports 2020-03-25 16:16:42
Workflows for screening emerging chemicals (INRA) Documents, reports 2020-03-25 16:16:43
1st annual list of exposure distributions and/or EU-wide reference values Documents, reports 2020-03-25 16:16:43
Report on workshop about opportunities and obstracles for linking HBM and health studies Documents, reports 2020-03-25 16:16:43
2018 Programme of training activities, materials and capacity building mechanisms (RUMC) Documents, reports 2020-03-25 16:16:43
1st Report on the content and use of the online library Documents, reports 2020-03-25 16:16:43
1st substance-group specific risk assessment Documents, reports 2020-03-25 16:16:42
Scoping documents for 2019 Documents, reports 2020-03-25 16:16:44
Prioritized list of known emerging chemicals (IRAS) Documents, reports 2020-03-25 16:16:42
Establishment of Governing Board Documents, reports 2020-03-25 16:16:42
Criteria for prioritisation of biomarkers, matrices and analytical methods (ANSP) Documents, reports 2020-03-25 16:16:43
First report on biobank activities (KI) Documents, reports 2020-03-25 16:16:43
Prioritised list of biomarkers, matrices and analytical methods for the 2nd prioritization round of substances Documents, reports 2020-03-25 16:16:43
1st-priorisation-Report on survey design: Study protocols, SOPs and Guidelines, tailored and transferred questionnaires for recruitment and sampling Documents, reports 2020-03-25 16:16:43
1st material for communication to participants, including informed consent Documents, reports 2020-03-25 16:16:43
Data management plan Documents, reports 2020-03-25 16:16:43
Template for AOP update report for selected priority substances Documents, reports 2020-03-25 16:16:43
Scoping documents for 2018 Documents, reports 2020-03-25 16:16:42
First Report on national needs, objectives of a long-term HBM4EU, inventory of funding mechanisms and recommendations for a sustainable HBM initiative in Europe and its organisation Documents, reports 2020-03-25 16:16:43
Selection criteria and inventory of effect biomarkers for the 2nd set of substances (UGR) Documents, reports 2020-03-13 11:15:10

Take a look to the deliverables list in detail:  detailed list of HBM4EU deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Marylène Rugard, Xavier Coumoul, Jean-Charles Carvaillo, Robert Barouki, Karine Audouze
Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches
published pages: 32-40, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfz214
Toxicological Sciences 173/1 2020-03-25
2020 Elina Drakvik, Rolf Altenburger, Yasunobu Aoki, Thomas Backhaus, Tina Bahadori, Robert Barouki, Werner Brack, Mark T.D. Cronin, Barbara Demeneix, Susanne Hougaard Bennekou, Jacob van Klaveren, Carsten Kneuer, Marike Kolossa-Gehring, Erik Lebret, Leo Posthuma, Lena Reiber, Cynthia Rider, Joëlle Rüegg, Giuseppe Testa, Bart van der Burg, Hilko van der Voet, A. Michael Warhurst, Bob van de Water, Ku
Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
published pages: 105267, ISSN: 0160-4120, DOI: 10.1016/j.envint.2019.105267
Environment International 134 2020-03-25
2019 Loreta Strumylaite, Rima Kregzdyte, Algirdas Bogusevicius, Lina Poskiene, Dale Baranauskiene, Darius Pranys
Cadmium Exposure and Risk of Breast Cancer by Histological and Tumor Receptor Subtype in White Caucasian Women: A Hospital-Based Case-Control Study
published pages: 3029, ISSN: 1422-0067, DOI: 10.3390/ijms20123029
International Journal of Molecular Sciences 20/12 2020-03-25
2019 Jean-Charles Carvaillo, Robert Barouki, Xavier Coumoul, Karine Audouze
Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach
published pages: 47005, ISSN: 0091-6765, DOI: 10.1289/ehp4200
Environmental Health Perspectives 127/4 2020-03-25
2017 Tamar Berman, Rebecca Goldsmith, Hagai Levine, Itamar Grotto
Human biomonitoring in Israel: Recent results and lessons learned
published pages: 6-12, ISSN: 1438-4639, DOI: 10.1016/j.ijheh.2016.09.008
International Journal of Hygiene and Environmental Health 220/2 2020-03-25
2019 Michiel Bastiaensen, Govindan Malarvannan, Frederic Been, Shanshan Yin, Yiming Yao, Johan Huygh, Katrien Clotman, Tom Schepens, Philippe G. Jorens, Adrian Covaci
Metabolites of phosphate flame retardants and alternative plasticizers in urine from intensive care patients
published pages: 590-596, ISSN: 0045-6535, DOI: 10.1016/J.CHEMOSPHERE.2019.05.280
Chemosphere 233 2020-03-25
2018 Bilal B Mughal, Jean-Baptiste Fini, Barbara A Demeneix
Thyroid-disrupting chemicals and brain development: an update
published pages: R160-R186, ISSN: 2049-3614, DOI: 10.1530/EC-18-0029
Endocrine Connections 7/4 2020-03-25
2019 Tiina Santonen, Alessandro Alimonti, Beatrice Bocca, Radu Corneliu Duca, Karen S. Galea, Lode Godderis, Thomas Göen, Bruno Gomes, Ogier Hanser, Ivo Iavicoli, Beata Janasik, Kate Jones, Mirja Kiilunen, Holger M. Koch, Elizabeth Leese, Veruscka Leso, Henriqueta Louro, Sophie Ndaw, Simo P. Porras, Alain Robert, Flavia Ruggieri, Paul T.J. Scheepers, Maria J. Silva, Susana Viegas, Wojciech Wasowicz, A
Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium
published pages: 108583, ISSN: 0013-9351, DOI: 10.1016/j.envres.2019.108583
Environmental Research 177 2020-03-25
2019 Kirsten A. Baken, Nathalie Lambrechts, Sylvie Remy, Vicente Mustieles, Andrea Rodríguez-Carrillo, Christiana M. Neophytou, Nicolas Olea, Greet Schoeters
A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects
published pages: 235-256, ISSN: 0013-9351, DOI: 10.1016/j.envres.2019.05.013
Environmental Research 175 2020-03-25
2019 Henriqueta Louro, Milla Heinälä, Jos Bessems, Jurgen Buekers, Theo Vermeire, Marjolijn Woutersen, Jacqueline van Engelen, Teresa Borges, Christophe Rousselle, Eva Ougier, Paula Alvito, Carla Martins, Ricardo Assunção, Maria João Silva, Anjoeka Pronk, Bernice Schaddelee-Scholten, Maria Del Carmen Gonzalez, Mercedes de Alba, Argelia Castaño, Susana Viegas, Tatjana Humar-Juric, Lijana Kononenko
Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
published pages: 727-737, ISSN: 1438-4639, DOI: 10.1016/j.ijheh.2019.05.009
International Journal of Hygiene and Environmental Health 222/5 2020-03-25
2018 Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie Nørager, Joëlle Rüegg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Åke Bergman
Current EU research activities on combined exposure to multiple chemicals
published pages: 544-562, ISSN: 0160-4120, DOI: 10.1016/j.envint.2018.07.037
Environment International 120 2020-03-25
2019 Dimosthenis A. Sarigiannis, Spyros Karakitsios, Elena Dominguez-Romero, Krystalia Papadaki, Celine Brochot, Vikas Kumar, Marta Schumacher, Moustapha Sy, Hans Mielke, Mathias Greiner, Marcel Mengelers, Martin Scheringer
Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative
published pages: 216-230, ISSN: 0013-9351, DOI: 10.1016/j.envres.2019.01.045
Environmental Research 172 2020-03-25
2017 Catherine Ganzleben, Jean-Philippe Antignac, Robert Barouki, Argelia Castaño, Ulrike Fiddicke, Jana Klánová, Erik Lebret, Nicolas Olea, Dimosthenis Sarigiannis, Greet R. Schoeters, Ovnair Sepai, Hanna Tolonen, Marike Kolossa-Gehring
Human biomonitoring as a tool to support chemicals regulation in the European Union
published pages: 94-97, ISSN: 1438-4639, DOI: 10.1016/j.ijheh.2017.01.007
International Journal of Hygiene and Environmental Health 220/2 2020-03-25
2019 Lola Bajard, Lisa Melymuk, Ludek Blaha
Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways
published pages: , ISSN: 2190-4707, DOI: 10.1186/s12302-019-0195-z
Environmental Sciences Europe 31/1 2020-03-25
2018 Jurgen Buekers, Madlen David, Gudrun Koppen, Jos Bessems, Martin Scheringer, Erik Lebret, Denis Sarigiannis, Marike Kolossa-Gehring, Marika Berglund, Greet Schoeters, Xenia Trier
Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population
published pages: 2085, ISSN: 1660-4601, DOI: 10.3390/ijerph15102085
International Journal of Environmental Research and Public Health 15/10 2020-03-25

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