Opendata, web and dolomites

SCREENED SIGNED

A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SCREENED project word cloud

Explore the words cloud of the SCREENED project. It provides you a very rough idea of what is the project "SCREENED" about.

purpose    screened    vivo    2d    mimic    scaffold    particles    construct    morphogenetic    rodent    individually    innovative    groups    bodies    complexity    bioprinted    assessment    function    biomimetic    vascular    biological    sex    magnetic    mechanistic    stem    human    assays    equipped    supporting    constructs    mode    anatomy    underlying    repopulated    gland    reproduce    classes    eds    endocrine    organoids    native    fit    engage    spatiotemporal    cell    doses    3d    superparamagnetic    animal    proteogenomics    safety    action    models    screen    stakeholder    ultimately    homing    effect    thyroid    geometrical    decellularized    precise    exposure    organoid    anatomical    biocompatible    sensitivity    performance    outcome    dimensional    microbioreactor    culture    chain    sensing    modular    ed    structure    replication    architecture    events    disruptors    gain    industry    vitro    regulatory    cells    hosted    composition    predict    adverse    spatial    specificity   

Project "SCREENED" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 5˙655˙088 €
 EC max contribution 5˙655˙088 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙795˙750.00
2    UNIVERSITA DEGLI STUDI DI PARMA IT (PARMA) participant 1˙000˙000.00
3    ARTTIC FR (PARIS) participant 564˙781.00
4    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 499˙200.00
5    PRESENS PRECISION SENSING GMBH DE (Regensburg) participant 493˙750.00
6    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 400˙000.00
7    CYPROTEX DISCOVERY LIMITED UK (ABINGDON OXFORDSHIRE) participant 351˙440.00
8    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 300˙167.00
9    ATTUROS LIMITED IE (LIMERICK CLARE) participant 250˙000.00

Map

 Project objective

SCREENED will develop 3 different three-dimensional (3D) in vitro assays based on rodent and human thyroid cell constructs. At different level of anatomical complexity, these assays will increasingly mimic the structure and function of the native thyroid gland, ultimately achieving the replication of its vascular anatomy and morphogenetic characteristics: 1) a 3D organoid based on stem-cell derived thyroid cells, 2) a decellularized scaffold able to reproduce the biological composition of a native thyroid, repopulated by the 3D organoids, and 3) a bioprinted construct with the 3D organoids able to mimic the spatial and geometrical architecture of a native thyroid. These 3D assays will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions. New superparamagnetic biocompatible and biomimetic particles will be used to produce “magnetic cells” to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs. The 3D assays will be used to screen the effect of endocrine disruptors (EDs) on the thyroid function in a unique biological sex-specific approach. Their performance will be assessed individually, in comparison with each other, and against in vivo studies. The 3D assays are expected to predict with more sensitivity and specificity the thyroid responses to different classes of EDs at low doses, compared to classical 2D in vitro assays or animal models. Supporting the “Adverse Outcome Pathway” concept, proteogenomics analysis and biological modelling of the underlying mode of action will be used to gain a mechanistic understanding of the chain of events from exposure to adverse effects on thyroid development and function. For future uptake, SCREENED will engage discussion with relevant stakeholder groups, including regulatory bodies and industry, to ensure that the assays are fit for purpose for ED safety assessment

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SCREENED" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SCREENED" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.1.)

ATHENA (2019)

Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

Read More  

ESPACE (2020)

Human Cell Atlas of the Pancreas

Read More  

BRAINTIME (2020)

Molecular atlas of the brain across the human lifespan

Read More  
lastchecktime (2020-07-05 21:01:52) correctly updated