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SCREENED SIGNED

A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Total Cost €

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EC-Contrib. €

0

Partnership

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 SCREENED project word cloud

Explore the words cloud of the SCREENED project. It provides you a very rough idea of what is the project "SCREENED" about.

particles    predict    sensitivity    supporting    industry    eds    biological    specificity    ed    biomimetic    doses    mimic    action    culture    3d    2d    equipped    precise    exposure    innovative    structure    mode    geometrical    gland    chain    sensing    sex    fit    stakeholder    magnetic    architecture    screen    rodent    mechanistic    native    endocrine    replication    function    spatiotemporal    scaffold    vivo    events    animal    cells    dimensional    outcome    disruptors    proteogenomics    modular    constructs    adverse    screened    morphogenetic    groups    decellularized    bioprinted    repopulated    composition    spatial    microbioreactor    ultimately    homing    hosted    assays    stem    thyroid    human    classes    performance    assessment    reproduce    purpose    organoids    anatomy    vitro    biocompatible    engage    models    superparamagnetic    construct    effect    underlying    cell    vascular    organoid    regulatory    gain    complexity    safety    bodies    individually    anatomical   

Project "SCREENED" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 5˙655˙088 €
 EC max contribution 5˙655˙088 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙795˙750.00
2    UNIVERSITA DEGLI STUDI DI PARMA IT (PARMA) participant 1˙000˙000.00
3    ARTTIC FR (PARIS) participant 564˙781.00
4    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 499˙200.00
5    PRESENS PRECISION SENSING GMBH DE (Regensburg) participant 493˙750.00
6    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 400˙000.00
7    CYPROTEX DISCOVERY LIMITED UK (ABINGDON OXFORDSHIRE) participant 351˙440.00
8    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 300˙167.00
9    ATTUROS LIMITED IE (LIMERICK CLARE) participant 250˙000.00

Map

 Project objective

SCREENED will develop 3 different three-dimensional (3D) in vitro assays based on rodent and human thyroid cell constructs. At different level of anatomical complexity, these assays will increasingly mimic the structure and function of the native thyroid gland, ultimately achieving the replication of its vascular anatomy and morphogenetic characteristics: 1) a 3D organoid based on stem-cell derived thyroid cells, 2) a decellularized scaffold able to reproduce the biological composition of a native thyroid, repopulated by the 3D organoids, and 3) a bioprinted construct with the 3D organoids able to mimic the spatial and geometrical architecture of a native thyroid. These 3D assays will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions. New superparamagnetic biocompatible and biomimetic particles will be used to produce “magnetic cells” to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs. The 3D assays will be used to screen the effect of endocrine disruptors (EDs) on the thyroid function in a unique biological sex-specific approach. Their performance will be assessed individually, in comparison with each other, and against in vivo studies. The 3D assays are expected to predict with more sensitivity and specificity the thyroid responses to different classes of EDs at low doses, compared to classical 2D in vitro assays or animal models. Supporting the “Adverse Outcome Pathway” concept, proteogenomics analysis and biological modelling of the underlying mode of action will be used to gain a mechanistic understanding of the chain of events from exposure to adverse effects on thyroid development and function. For future uptake, SCREENED will engage discussion with relevant stakeholder groups, including regulatory bodies and industry, to ensure that the assays are fit for purpose for ED safety assessment

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The information about "SCREENED" are provided by the European Opendata Portal: CORDIS opendata.

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