Opendata, web and dolomites

SCREENED SIGNED

A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SCREENED project word cloud

Explore the words cloud of the SCREENED project. It provides you a very rough idea of what is the project "SCREENED" about.

scaffold    modular    adverse    sensing    effect    underlying    function    composition    supporting    reproduce    classes    magnetic    rodent    biomimetic    homing    structure    precise    bodies    chain    ultimately    ed    vascular    equipped    constructs    particles    doses    purpose    action    regulatory    bioprinted    biocompatible    fit    screened    industry    mimic    microbioreactor    groups    events    models    cells    performance    exposure    decellularized    2d    innovative    dimensional    safety    vivo    anatomical    organoids    assays    spatial    eds    native    stem    specificity    human    replication    endocrine    complexity    individually    mechanistic    thyroid    repopulated    culture    spatiotemporal    disruptors    screen    superparamagnetic    architecture    hosted    predict    gland    anatomy    engage    assessment    organoid    stakeholder    gain    sensitivity    3d    morphogenetic    sex    mode    cell    animal    proteogenomics    biological    vitro    outcome    geometrical    construct   

Project "SCREENED" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 5˙655˙088 €
 EC max contribution 5˙655˙088 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙795˙750.00
2    UNIVERSITA DEGLI STUDI DI PARMA IT (PARMA) participant 1˙000˙000.00
3    ARTTIC FR (PARIS) participant 564˙781.00
4    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 499˙200.00
5    PRESENS PRECISION SENSING GMBH DE (Regensburg) participant 493˙750.00
6    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 400˙000.00
7    CYPROTEX DISCOVERY LIMITED UK (ABINGDON OXFORDSHIRE) participant 351˙440.00
8    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 300˙167.00
9    ATTUROS LIMITED IE (LIMERICK CLARE) participant 250˙000.00

Map

 Project objective

SCREENED will develop 3 different three-dimensional (3D) in vitro assays based on rodent and human thyroid cell constructs. At different level of anatomical complexity, these assays will increasingly mimic the structure and function of the native thyroid gland, ultimately achieving the replication of its vascular anatomy and morphogenetic characteristics: 1) a 3D organoid based on stem-cell derived thyroid cells, 2) a decellularized scaffold able to reproduce the biological composition of a native thyroid, repopulated by the 3D organoids, and 3) a bioprinted construct with the 3D organoids able to mimic the spatial and geometrical architecture of a native thyroid. These 3D assays will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions. New superparamagnetic biocompatible and biomimetic particles will be used to produce “magnetic cells” to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs. The 3D assays will be used to screen the effect of endocrine disruptors (EDs) on the thyroid function in a unique biological sex-specific approach. Their performance will be assessed individually, in comparison with each other, and against in vivo studies. The 3D assays are expected to predict with more sensitivity and specificity the thyroid responses to different classes of EDs at low doses, compared to classical 2D in vitro assays or animal models. Supporting the “Adverse Outcome Pathway” concept, proteogenomics analysis and biological modelling of the underlying mode of action will be used to gain a mechanistic understanding of the chain of events from exposure to adverse effects on thyroid development and function. For future uptake, SCREENED will engage discussion with relevant stakeholder groups, including regulatory bodies and industry, to ensure that the assays are fit for purpose for ED safety assessment

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SCREENED" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SCREENED" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.1.)

BIND (2020)

Brain Involvement iN Dystrophinopathies

Read More  

ARREST-TB (2019)

Accurate, Rapid, Robust and Economical diagnostic technoliogieS for Tuberculosis

Read More  

OBERON (2019)

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Read More