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SCREENED SIGNED

A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Total Cost €

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EC-Contrib. €

0

Partnership

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 SCREENED project word cloud

Explore the words cloud of the SCREENED project. It provides you a very rough idea of what is the project "SCREENED" about.

structure    classes    magnetic    endocrine    mechanistic    groups    scaffold    outcome    geometrical    industry    effect    animal    specificity    exposure    3d    mode    biological    mimic    spatial    individually    bodies    proteogenomics    hosted    replication    assays    repopulated    regulatory    sensitivity    adverse    cell    native    engage    constructs    bioprinted    models    underlying    function    construct    screened    dimensional    sensing    vivo    spatiotemporal    gain    stakeholder    decellularized    screen    innovative    action    precise    disruptors    assessment    chain    anatomy    particles    modular    cells    thyroid    microbioreactor    ed    fit    composition    biocompatible    human    doses    vascular    purpose    eds    rodent    sex    ultimately    reproduce    complexity    anatomical    culture    homing    organoid    biomimetic    supporting    safety    gland    performance    architecture    morphogenetic    vitro    equipped    2d    organoids    superparamagnetic    stem    events    predict   

Project "SCREENED" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 5˙655˙088 €
 EC max contribution 5˙655˙088 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙795˙750.00
2    UNIVERSITA DEGLI STUDI DI PARMA IT (PARMA) participant 1˙000˙000.00
3    ARTTIC FR (PARIS) participant 564˙781.00
4    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 499˙200.00
5    PRESENS PRECISION SENSING GMBH DE (Regensburg) participant 493˙750.00
6    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 400˙000.00
7    CYPROTEX DISCOVERY LIMITED UK (ABINGDON OXFORDSHIRE) participant 351˙440.00
8    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 300˙167.00
9    ATTUROS LIMITED IE (LIMERICK CLARE) participant 250˙000.00

Map

 Project objective

SCREENED will develop 3 different three-dimensional (3D) in vitro assays based on rodent and human thyroid cell constructs. At different level of anatomical complexity, these assays will increasingly mimic the structure and function of the native thyroid gland, ultimately achieving the replication of its vascular anatomy and morphogenetic characteristics: 1) a 3D organoid based on stem-cell derived thyroid cells, 2) a decellularized scaffold able to reproduce the biological composition of a native thyroid, repopulated by the 3D organoids, and 3) a bioprinted construct with the 3D organoids able to mimic the spatial and geometrical architecture of a native thyroid. These 3D assays will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions. New superparamagnetic biocompatible and biomimetic particles will be used to produce “magnetic cells” to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs. The 3D assays will be used to screen the effect of endocrine disruptors (EDs) on the thyroid function in a unique biological sex-specific approach. Their performance will be assessed individually, in comparison with each other, and against in vivo studies. The 3D assays are expected to predict with more sensitivity and specificity the thyroid responses to different classes of EDs at low doses, compared to classical 2D in vitro assays or animal models. Supporting the “Adverse Outcome Pathway” concept, proteogenomics analysis and biological modelling of the underlying mode of action will be used to gain a mechanistic understanding of the chain of events from exposure to adverse effects on thyroid development and function. For future uptake, SCREENED will engage discussion with relevant stakeholder groups, including regulatory bodies and industry, to ensure that the assays are fit for purpose for ED safety assessment

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The information about "SCREENED" are provided by the European Opendata Portal: CORDIS opendata.

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