Opendata, web and dolomites

ImmuNiche SIGNED

Identifying spatial determinants of immune cell fate commitment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ImmuNiche project word cloud

Explore the words cloud of the ImmuNiche project. It provides you a very rough idea of what is the project "ImmuNiche" about.

visualizing    niche    pinpoint    situ    treatment    signals    marrow    combination    bone    regulators    strategy    composition    predicted    malignant    preferential    malignancies    giving    conservation    underlying    therapeutic    microenvironmental    hybridization    myelodysplastic    tissue    normal    model    patient    cell    spatial    blood    prognosis    disease    architecture    globally    determinants    fluorescent    cutting    fate    sections    tissues    niches    functionally    commitment    integrating    single    co    mouse    patients    interactions    decades    microenvrionmental    poor    molecule    differentiation    conserved    mammalian    models    representing    hematopoietic    multiplexed    syndromes    computational    human    murine    prevention    rna    resolution    poorly    compare    localization    resolve    trajectories    healthy    jointly    pathogenesis    cytokine    few    molecular    edge    reveal    leukaemia    250    techniques    reference    microenvironment    predict    mds    gene    stem    cells    sub    progenitor    expression    seq    resident    mice    donors    frequent    mechanisms    blueprint    types    markers   

Project "ImmuNiche" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙997˙500.00

Map

 Project objective

The complex architecture of the mammalian hematopoietic system has been studied for decades, yet the molecular mechanisms underlying cell fate commitment remain poorly understood. Although cytokine signals are major determinants of hematopoietic cell fate, only few niches of stem and progenitor cells have been characterized. Here, we propose to resolve the cell type composition of mouse bone marrow by integrating single-cell RNA-seq with high-resolution spatial analysis of gene expression in tissue sections, visualizing ~250 cell type specific markers by multiplexed single-molecule RNA fluorescent in situ hybridization. This approach will reveal preferential co-localization of hematopoietic cells with other bone marrow-resident cell types, and globally predict niches of hematopoietic progenitor sub-types to pinpoint microenvrionmental determinants of hematopoietic cell fate. Based on this reference we will investigate the role of the microenvironment in the pathogenesis of myelodysplastic syndromes (MDS), representing one of the most frequent blood cell malignancies, commonly giving rise to leukaemia with poor prognosis. To investigate conservation of microenvironmental determinants of normal and malignant hematopoietic differentiation in human, we will apply the same strategy to healthy donors and human MDS patients and compare predicted cell types, differentiation trajectories, and niche interactions to those derived from healthy mice and murine MDS models. This approach will reveal conserved niche regulators of cell fate commitment involved in disease pathogenesis, which we will functionally analyse in murine models to identify novel therapeutic targets for prevention and treatment of MDS. Our approach represents a blueprint for investigating human malignancies of under-characterized tissues by applying cutting-edge high-resolution techniques in combination with advanced computational methods to jointly analyse the murine model and human patient microenvironment.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNICHE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNICHE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

iNANOVAC4CANCER (2019)

BIOHYBRID AND BIODEGRADABLE NANOVACCINES FOR CANCER IMMUNOTHERAPY

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More