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ImmuNiche SIGNED

Identifying spatial determinants of immune cell fate commitment

Total Cost €

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EC-Contrib. €

0

Partnership

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 ImmuNiche project word cloud

Explore the words cloud of the ImmuNiche project. It provides you a very rough idea of what is the project "ImmuNiche" about.

computational    rna    strategy    cell    gene    seq    blueprint    prevention    hybridization    giving    globally    resolve    resolution    mechanisms    malignancies    hematopoietic    preferential    compare    tissues    trajectories    single    reveal    jointly    predicted    spatial    leukaemia    situ    fluorescent    microenvironmental    mouse    bone    molecular    conserved    syndromes    normal    niche    tissue    representing    pinpoint    mice    poor    functionally    stem    human    cytokine    cells    few    treatment    mds    microenvironment    frequent    determinants    donors    techniques    molecule    co    mammalian    conservation    expression    niches    models    regulators    malignant    disease    model    marrow    poorly    markers    myelodysplastic    prognosis    types    integrating    patient    cutting    multiplexed    combination    blood    commitment    pathogenesis    architecture    reference    localization    progenitor    signals    murine    250    resident    predict    sub    differentiation    decades    microenvrionmental    sections    underlying    therapeutic    visualizing    interactions    composition    fate    patients    edge    healthy   

Project "ImmuNiche" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙997˙500.00

Map

 Project objective

The complex architecture of the mammalian hematopoietic system has been studied for decades, yet the molecular mechanisms underlying cell fate commitment remain poorly understood. Although cytokine signals are major determinants of hematopoietic cell fate, only few niches of stem and progenitor cells have been characterized. Here, we propose to resolve the cell type composition of mouse bone marrow by integrating single-cell RNA-seq with high-resolution spatial analysis of gene expression in tissue sections, visualizing ~250 cell type specific markers by multiplexed single-molecule RNA fluorescent in situ hybridization. This approach will reveal preferential co-localization of hematopoietic cells with other bone marrow-resident cell types, and globally predict niches of hematopoietic progenitor sub-types to pinpoint microenvrionmental determinants of hematopoietic cell fate. Based on this reference we will investigate the role of the microenvironment in the pathogenesis of myelodysplastic syndromes (MDS), representing one of the most frequent blood cell malignancies, commonly giving rise to leukaemia with poor prognosis. To investigate conservation of microenvironmental determinants of normal and malignant hematopoietic differentiation in human, we will apply the same strategy to healthy donors and human MDS patients and compare predicted cell types, differentiation trajectories, and niche interactions to those derived from healthy mice and murine MDS models. This approach will reveal conserved niche regulators of cell fate commitment involved in disease pathogenesis, which we will functionally analyse in murine models to identify novel therapeutic targets for prevention and treatment of MDS. Our approach represents a blueprint for investigating human malignancies of under-characterized tissues by applying cutting-edge high-resolution techniques in combination with advanced computational methods to jointly analyse the murine model and human patient microenvironment.

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The information about "IMMUNICHE" are provided by the European Opendata Portal: CORDIS opendata.

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