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ImmuNiche SIGNED

Identifying spatial determinants of immune cell fate commitment

Total Cost €

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EC-Contrib. €

0

Partnership

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 ImmuNiche project word cloud

Explore the words cloud of the ImmuNiche project. It provides you a very rough idea of what is the project "ImmuNiche" about.

prognosis    single    strategy    model    tissue    mouse    cutting    regulators    molecule    edge    cytokine    gene    types    malignancies    poor    blood    conservation    niches    microenvironment    commitment    leukaemia    frequent    sections    underlying    prevention    treatment    fate    jointly    mds    few    models    decades    globally    myelodysplastic    compare    hybridization    tissues    differentiation    resolve    architecture    niche    expression    therapeutic    predict    conserved    patient    poorly    marrow    pathogenesis    cells    donors    cell    localization    determinants    signals    human    giving    preferential    syndromes    bone    malignant    250    multiplexed    composition    reference    mammalian    normal    computational    mechanisms    functionally    healthy    molecular    resident    sub    fluorescent    seq    mice    murine    progenitor    spatial    rna    hematopoietic    representing    predicted    co    visualizing    resolution    integrating    trajectories    situ    disease    microenvironmental    stem    blueprint    microenvrionmental    reveal    patients    interactions    markers    techniques    pinpoint    combination   

Project "ImmuNiche" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙997˙500.00

Map

 Project objective

The complex architecture of the mammalian hematopoietic system has been studied for decades, yet the molecular mechanisms underlying cell fate commitment remain poorly understood. Although cytokine signals are major determinants of hematopoietic cell fate, only few niches of stem and progenitor cells have been characterized. Here, we propose to resolve the cell type composition of mouse bone marrow by integrating single-cell RNA-seq with high-resolution spatial analysis of gene expression in tissue sections, visualizing ~250 cell type specific markers by multiplexed single-molecule RNA fluorescent in situ hybridization. This approach will reveal preferential co-localization of hematopoietic cells with other bone marrow-resident cell types, and globally predict niches of hematopoietic progenitor sub-types to pinpoint microenvrionmental determinants of hematopoietic cell fate. Based on this reference we will investigate the role of the microenvironment in the pathogenesis of myelodysplastic syndromes (MDS), representing one of the most frequent blood cell malignancies, commonly giving rise to leukaemia with poor prognosis. To investigate conservation of microenvironmental determinants of normal and malignant hematopoietic differentiation in human, we will apply the same strategy to healthy donors and human MDS patients and compare predicted cell types, differentiation trajectories, and niche interactions to those derived from healthy mice and murine MDS models. This approach will reveal conserved niche regulators of cell fate commitment involved in disease pathogenesis, which we will functionally analyse in murine models to identify novel therapeutic targets for prevention and treatment of MDS. Our approach represents a blueprint for investigating human malignancies of under-characterized tissues by applying cutting-edge high-resolution techniques in combination with advanced computational methods to jointly analyse the murine model and human patient microenvironment.

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The information about "IMMUNICHE" are provided by the European Opendata Portal: CORDIS opendata.

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