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METACELL SIGNED

Artificial metabolic cells for biomanufacturing of bio-based chiral fine chemicals

Total Cost €

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EC-Contrib. €

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Partnership

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 METACELL project word cloud

Explore the words cloud of the METACELL project. It provides you a very rough idea of what is the project "METACELL" about.

versatile    drugs    catalyzed    mission    biosynthetic    porous    stability    usability    industrial    materials    palette    smart    soluble    metabolism    protein    innovative    least    organization    chemicals    solid    selectivity    outputs    confined    vitro    ameliorate    engineering    solutions    rationally    amcs    synthesis    efficient    biomanufacturing    restricted    sustainable    chassis    prototyping    surface    efficiency    free    chemical    immobilization    surfaces    enzyme    immobilizing    ing    bio    mere    point    discovery    reactors    cell    active    artificial    enzymes    industrially    integrative    organic    replace    spatial    fuel    serve    heterogeneous    productivity    platform    networks    immobilized    play    flow    modify    cells    cascades    metabolic    expanding    care    technological    fine    self    performance    continuous    demand    biocatalysts    isolated    tools    re    material    hamper    hierarchical    one    sufficient    successful    chemistry    packed    metacell    combinatorial    understand   

Project "METACELL" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙995˙894 €
 EC max contribution 1˙995˙894 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 1˙995˙894.00

Map

 Project objective

One of the major challenges of sustainable chemistry is expanding the palette of bio-based chemicals that can replace, or at least ameliorate, the exploitation of fuel-based chemicals. Cell-free metabolic engineering using soluble enzymes is an emerging and versatile approach that seeks to increase the selectivity and productivity of chemical biomanufacturing processes. However, soluble and isolated enzymes present major issues in terms of efficiency, stability and re-usability that hamper industrial applications. To solve these problems, enzymes can be rationally immobilized on smart materials resulting in robust, efficient and self-sufficient heterogeneous biocatalysts, but immobilization is still restricted to simple enzyme cascades. METACELL mission is developing self-sufficient artificial metabolic cells (AMCs) by immobilizing complex metabolic networks on hierarchical porous materials. To this aim, the solid surfaces must play an active role in the chemical process rather than just being a mere immobilization support. This integrative proposal will exploit protein engineering, surface chemistry, bio-organic chemistry and protein immobilization tools for the successful development of 1) a cell-free artificial metabolism, 2) innovative engineering tools to modify both enzyme and material surfaces and 3) continuous synthesis of industrially relevant fine chemicals catalyzed by AMCs packed into flow reactors. The resulting technology of METACELL will serve as a prototyping platform to test artificial biosynthetic pathways with application in combinatorial chemistry (e.g drugs discovery). METACELL may also offer long-term solutions for the on-demand production of drugs at the point-of-care. In addition to the technological outputs, METACELL will also provide essential information to understand how spatial organization of multi-enzyme systems affect the performance of in vitro biosynthetic pathways confined into artificial chassis (solid materials).

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The information about "METACELL" are provided by the European Opendata Portal: CORDIS opendata.

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