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METACELL SIGNED

Artificial metabolic cells for biomanufacturing of bio-based chiral fine chemicals

Total Cost €

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EC-Contrib. €

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Partnership

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 METACELL project word cloud

Explore the words cloud of the METACELL project. It provides you a very rough idea of what is the project "METACELL" about.

one    ing    heterogeneous    efficient    tools    catalyzed    amcs    performance    selectivity    sufficient    reactors    mere    integrative    cells    re    spatial    combinatorial    chassis    hierarchical    usability    demand    smart    stability    cascades    productivity    vitro    restricted    engineering    confined    biomanufacturing    bio    modify    ameliorate    networks    expanding    organization    cell    efficiency    immobilization    protein    biosynthetic    biocatalysts    immobilized    active    palette    successful    flow    replace    hamper    prototyping    fine    metabolic    soluble    play    mission    solutions    outputs    chemicals    industrially    technological    rationally    solid    organic    materials    fuel    isolated    metabolism    material    chemistry    packed    platform    least    free    chemical    drugs    synthesis    artificial    understand    immobilizing    care    discovery    metacell    enzymes    versatile    enzyme    industrial    surfaces    point    porous    continuous    surface    self    serve    innovative    sustainable   

Project "METACELL" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙995˙894 €
 EC max contribution 1˙995˙894 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 1˙995˙894.00

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 Project objective

One of the major challenges of sustainable chemistry is expanding the palette of bio-based chemicals that can replace, or at least ameliorate, the exploitation of fuel-based chemicals. Cell-free metabolic engineering using soluble enzymes is an emerging and versatile approach that seeks to increase the selectivity and productivity of chemical biomanufacturing processes. However, soluble and isolated enzymes present major issues in terms of efficiency, stability and re-usability that hamper industrial applications. To solve these problems, enzymes can be rationally immobilized on smart materials resulting in robust, efficient and self-sufficient heterogeneous biocatalysts, but immobilization is still restricted to simple enzyme cascades. METACELL mission is developing self-sufficient artificial metabolic cells (AMCs) by immobilizing complex metabolic networks on hierarchical porous materials. To this aim, the solid surfaces must play an active role in the chemical process rather than just being a mere immobilization support. This integrative proposal will exploit protein engineering, surface chemistry, bio-organic chemistry and protein immobilization tools for the successful development of 1) a cell-free artificial metabolism, 2) innovative engineering tools to modify both enzyme and material surfaces and 3) continuous synthesis of industrially relevant fine chemicals catalyzed by AMCs packed into flow reactors. The resulting technology of METACELL will serve as a prototyping platform to test artificial biosynthetic pathways with application in combinatorial chemistry (e.g drugs discovery). METACELL may also offer long-term solutions for the on-demand production of drugs at the point-of-care. In addition to the technological outputs, METACELL will also provide essential information to understand how spatial organization of multi-enzyme systems affect the performance of in vitro biosynthetic pathways confined into artificial chassis (solid materials).

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The information about "METACELL" are provided by the European Opendata Portal: CORDIS opendata.

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