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METACELL SIGNED

Artificial metabolic cells for biomanufacturing of bio-based chiral fine chemicals

Total Cost €

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EC-Contrib. €

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Partnership

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 METACELL project word cloud

Explore the words cloud of the METACELL project. It provides you a very rough idea of what is the project "METACELL" about.

organic    artificial    chemicals    integrative    usability    fuel    metabolism    amcs    restricted    solutions    reactors    expanding    ing    innovative    cell    re    sustainable    chemistry    solid    least    rationally    smart    fine    continuous    drugs    productivity    modify    outputs    one    immobilization    efficiency    material    discovery    point    hierarchical    play    metabolic    engineering    efficient    enzymes    heterogeneous    metacell    immobilized    versatile    active    cascades    demand    protein    free    hamper    industrially    mere    catalyzed    sufficient    biocatalysts    surfaces    platform    enzyme    networks    care    materials    ameliorate    biomanufacturing    vitro    technological    industrial    self    chassis    palette    synthesis    chemical    tools    serve    organization    porous    stability    selectivity    bio    performance    soluble    understand    successful    combinatorial    biosynthetic    flow    surface    confined    isolated    replace    immobilizing    packed    spatial    prototyping    mission    cells   

Project "METACELL" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙995˙894 €
 EC max contribution 1˙995˙894 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 1˙995˙894.00

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 Project objective

One of the major challenges of sustainable chemistry is expanding the palette of bio-based chemicals that can replace, or at least ameliorate, the exploitation of fuel-based chemicals. Cell-free metabolic engineering using soluble enzymes is an emerging and versatile approach that seeks to increase the selectivity and productivity of chemical biomanufacturing processes. However, soluble and isolated enzymes present major issues in terms of efficiency, stability and re-usability that hamper industrial applications. To solve these problems, enzymes can be rationally immobilized on smart materials resulting in robust, efficient and self-sufficient heterogeneous biocatalysts, but immobilization is still restricted to simple enzyme cascades. METACELL mission is developing self-sufficient artificial metabolic cells (AMCs) by immobilizing complex metabolic networks on hierarchical porous materials. To this aim, the solid surfaces must play an active role in the chemical process rather than just being a mere immobilization support. This integrative proposal will exploit protein engineering, surface chemistry, bio-organic chemistry and protein immobilization tools for the successful development of 1) a cell-free artificial metabolism, 2) innovative engineering tools to modify both enzyme and material surfaces and 3) continuous synthesis of industrially relevant fine chemicals catalyzed by AMCs packed into flow reactors. The resulting technology of METACELL will serve as a prototyping platform to test artificial biosynthetic pathways with application in combinatorial chemistry (e.g drugs discovery). METACELL may also offer long-term solutions for the on-demand production of drugs at the point-of-care. In addition to the technological outputs, METACELL will also provide essential information to understand how spatial organization of multi-enzyme systems affect the performance of in vitro biosynthetic pathways confined into artificial chassis (solid materials).

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The information about "METACELL" are provided by the European Opendata Portal: CORDIS opendata.

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