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DDREAMM SIGNED

Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Total Cost €

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EC-Contrib. €

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Partnership

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 DDREAMM project word cloud

Explore the words cloud of the DDREAMM project. It provides you a very rough idea of what is the project "DDREAMM" about.

editing    outcomes    types    viability    synthetic    comprise    lethal    resistance    uncover    alleles    precisely    hypo    framework    maps    technologies    hereditary    multiple    gene    cas    diseases    genetic    diverse    aggressive    deeply    ddr    agents    disorders    morph    mass    hyper    suppressive    deficiencies    therapeutic    vulnerabilities    biology    functional    genomes    interaction    cellular    crispr    treat    chemical    sophisticated    reveal    underpins    enzyme    surveillance    harnessed    molecule    interrogate    human    multidisciplinary    yield    therapeutics    cell    networks    phenotypes    monitor    therapies    transcriptional    damaging    tools    small    ranging    eukaryotic    sporadic    signaling    treatments    dna    damage    explaining    events    underpin    beginning    interactions    understand    cancers    sum    insights    inherited    logic    generation    protect    create    inhibitors    spectrometry    cells    repair    cutting    physical    mechanistic    powerful    genome    fundamental    deficiency    edge    speed    sensitivity    cancer   

Project "DDREAMM" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 8˙865˙965 €
 EC max contribution 8˙865˙965 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2026-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 3˙428˙750.00
2    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) participant 2˙954˙000.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 2˙483˙215.00

Map

 Project objective

To monitor and protect their genomes, eukaryotic cells have evolved sophisticated DNA-damage response (DDR) systems that comprise DNA repair and DNA-damage signaling processes. DDR deficiencies are associated with diverse human disorders, ranging from aggressive hereditary and sporadic cancers to inherited genetic diseases. The impact of DNA repair has also recently been harnessed to treat diseases through “synthetic lethal” cancer treatments and CRISPR-Cas genome editing. However, the fundamental interactions between DDR pathways that underpin such therapeutic opportunities are still not well understood. Furthermore, we are only just beginning to understand how suppressive functional interactions (so-called “synthetic viability”) can lead to resistance to DDR-targeting therapeutics. Our proposed research will address these important issues by using cutting-edge technologies in gene editing and chemical biology, and by taking a multidisciplinary approach to create deeply integrated genetic and physical maps of DDR pathways and interactions in many human cell types. Next-generation CRISPR-Cas transcriptional genome-wide approaches will be used to uncover hypo- and hyper-morph alleles that affect cellular sensitivity to DNA-damaging agents and DDR-enzyme inhibitors, thus providing insights into DDR events and explaining human DDR-deficiency phenotypes. Mass spectrometry and in-depth mechanistic studies will establish physical interaction networks within the genetic framework and reveal the signaling logic that underpins DDR outcomes and vulnerabilities. With chemical-genetic approaches, we will develop small molecule tools to precisely interrogate DDR pathways and that could lead to new therapeutic agents. In sum, our work should provide major insights into human genome surveillance in multiple cell types, yield powerful tools to precisely control DNA repair outcomes, and speed the development of new therapies for cancer and other diseases.

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The information about "DDREAMM" are provided by the European Opendata Portal: CORDIS opendata.

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