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DDREAMM SIGNED

Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Total Cost €

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EC-Contrib. €

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Partnership

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 DDREAMM project word cloud

Explore the words cloud of the DDREAMM project. It provides you a very rough idea of what is the project "DDREAMM" about.

sophisticated    events    disorders    eukaryotic    cancers    speed    cell    monitor    sporadic    explaining    insights    deficiency    comprise    inherited    diseases    human    genetic    beginning    yield    types    underpin    suppressive    morph    gene    outcomes    physical    synthetic    deeply    agents    maps    hyper    networks    hereditary    cells    transcriptional    viability    uncover    cas    cutting    cancer    tools    resistance    repair    sum    signaling    deficiencies    treat    precisely    chemical    generation    therapeutic    sensitivity    editing    vulnerabilities    multidisciplinary    underpins    diverse    genome    edge    therapies    create    ddr    multiple    molecule    logic    framework    small    powerful    ranging    treatments    phenotypes    damage    interaction    lethal    mass    dna    interactions    spectrometry    surveillance    genomes    cellular    technologies    therapeutics    enzyme    aggressive    interrogate    mechanistic    damaging    alleles    functional    understand    crispr    hypo    protect    inhibitors    fundamental    reveal    harnessed    biology   

Project "DDREAMM" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 8˙865˙965 €
 EC max contribution 8˙865˙965 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2026-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 3˙428˙750.00
2    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) participant 2˙954˙000.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 2˙483˙215.00

Map

 Project objective

To monitor and protect their genomes, eukaryotic cells have evolved sophisticated DNA-damage response (DDR) systems that comprise DNA repair and DNA-damage signaling processes. DDR deficiencies are associated with diverse human disorders, ranging from aggressive hereditary and sporadic cancers to inherited genetic diseases. The impact of DNA repair has also recently been harnessed to treat diseases through “synthetic lethal” cancer treatments and CRISPR-Cas genome editing. However, the fundamental interactions between DDR pathways that underpin such therapeutic opportunities are still not well understood. Furthermore, we are only just beginning to understand how suppressive functional interactions (so-called “synthetic viability”) can lead to resistance to DDR-targeting therapeutics. Our proposed research will address these important issues by using cutting-edge technologies in gene editing and chemical biology, and by taking a multidisciplinary approach to create deeply integrated genetic and physical maps of DDR pathways and interactions in many human cell types. Next-generation CRISPR-Cas transcriptional genome-wide approaches will be used to uncover hypo- and hyper-morph alleles that affect cellular sensitivity to DNA-damaging agents and DDR-enzyme inhibitors, thus providing insights into DDR events and explaining human DDR-deficiency phenotypes. Mass spectrometry and in-depth mechanistic studies will establish physical interaction networks within the genetic framework and reveal the signaling logic that underpins DDR outcomes and vulnerabilities. With chemical-genetic approaches, we will develop small molecule tools to precisely interrogate DDR pathways and that could lead to new therapeutic agents. In sum, our work should provide major insights into human genome surveillance in multiple cell types, yield powerful tools to precisely control DNA repair outcomes, and speed the development of new therapies for cancer and other diseases.

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The information about "DDREAMM" are provided by the European Opendata Portal: CORDIS opendata.

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