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GeneBodyMethylation TERMINATED

Resolving the Nuts and Bolts of Gene Body Methylation

Total Cost €

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EC-Contrib. €

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Partnership

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 GeneBodyMethylation project word cloud

Explore the words cloud of the GeneBodyMethylation project. It provides you a very rough idea of what is the project "GeneBodyMethylation" about.

customized    developmental    context    changing    dna    generations    fundamental    scientists    evolutionary    gene    animal    cytosine    organisms    plants    despite    silencing    simply    ch3    yielding    explore    conserved    believe    roles    gap    regulators    genomes    influenced    searched    epigenetic    body    sequences    interpreters    chicken    artificially    fill    actively    replication    subregions    exist    regulating    termed    transcriptional    subset    poorly    found    genome    breakthroughs    tools    precise    binding    base    events    missing    conundrum    transmitted    regulates    diseases    treating    covalent    group    function    functional    methyl    plays    genomic    transcribed    entire    genetic    discover    hypomethylated    array    ultimately    cellular    plant    egg    inside    memorize    thousands    mostly    hence    biochemical    methylation    output    genes    code    biological    generate    transcription    human    crops    full    either    eukaryotes    molecular    comprehension   

Project "GeneBodyMethylation" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙500˙000.00

Map

 Project objective

DNA methylation, the covalent binding of a methyl group (CH3) to cytosine base, regulates the genome activity and plays a fundamental developmental role in eukaryotes. Its epigenetic characteristics of regulating transcription without changing the genetic code together with the ability to be transmitted through DNA replication allow organisms to memorize cellular events for many generations. DNA methylation is mostly known for its role in transcriptional silencing; however, its functional output is more complex and is influenced in part by its DNA context. Recent genomic studies, have found DNA methylation to be targeted inside sequences of actively transcribed genes, thus termed gene body methylation. Despite being an evolutionary conserved and a robust methylation pathway targeted to thousands of genes in animal and plant genomes, the function of gene body methylation is still poorly understood at both the molecular and functional level. Similar to the chicken and egg conundrum, because we do not know what gene body methylation does, therefore scientists could not apply its function to discover its regulators either. Gene body methylation is targeted to a very specific subset and subregions of genes, thus we strongly believe that specific factors exist and are missing simply because that no one has ever searched for them before. Hence, to make major breakthroughs in the field, our approach is to artificially generate gene-body-specific hypomethylated plants that together with customized genetic and biochemical systems will allow us to discover regulators and interpreters of gene body methylation. Using these unique genetic tools and novel molecular factors, we will be able to ultimately explore the particular biological roles of gene body methylation. These findings will fill the gap towards a full comprehension of the entire functional array of DNA methylation, and to its more precise exploitation in yielding better crops and in treating human diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Rafael Yaari, Aviva Katz, Katherine Domb, Keith D. Harris, Assaf Zemach, Nir Ohad
RdDM-independent de novo and heterochromatin DNA methylation by plant CMT and DNMT3 orthologs
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09496-0
Nature Communications 10/1 2020-01-20
2018 Tamir Tuller, Alon Diament, Avital Yahalom, Assaf Zemach, Shimshi Atar, Daniel A Chamovitz
The COP9 signalosome influences the epigenetic landscape of Arabidopsis thaliana
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty1053
Bioinformatics 2020-01-20
2018 Narendra Singh Yadav, Janardan Khadka, Katherine Domb, Assaf Zemach, Gideon Grafi
CMT3 and SUVH4/KYP silence the exonic Evelknievel retroelement to allow for reconstitution of CMT1 mRNA
published pages: , ISSN: 1756-8935, DOI: 10.1186/s13072-018-0240-y
Epigenetics & Chromatin 11/1 2020-01-20

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