Opendata, web and dolomites

MitoQuant SIGNED

Development of Deep-UV Quantitative Microscopy for the Study of Mitochondrial Dysfunction

Total Cost €


EC-Contrib. €






 MitoQuant project word cloud

Explore the words cloud of the MitoQuant project. It provides you a very rough idea of what is the project "MitoQuant" about.

suited    fluorescence    issue    noising    overexpression    cellular    techniques    sequences    play    molecular    live    contrast    apertures    dna    reconstruction    algorithms    microscope    labelled    learning    label    diabetes    imaging    network    circumvents    mitoquant    continued    quantitative    neurodegeneration    cas9    levels    structured    mitochondrial    fluorescent    deductions    microscopy    organelles    hence    routines    first    specificity    extract    cell    establishing    de    start    machine    record    researcher    vital    crispr    interplay    highest    possibility    compiled    resolution    illumination    autofluorescence    turn    numerical    counter    concurrently    simultaneously    skews    building    technique    linked    excellent    microscopes    gene    sparse    science    little    uv    signal    quality    classify    dysfunction    adds    surprising    originally    presented    employ    dynamics    overshadowing    good    wavelengths    mitochondria    worry    editor    time    diseases    free    100nm    reduces    track    neural    modifies    instrument    fluorescently    contextual    light    superresolution    signals    deep    matching    image    material    experiments    optics    machinery    proteins    transfection    strives    trained   

Project "MitoQuant" data sheet

The following table provides information about the project.


Organization address
city: TROMSO
postcode: 9019

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 202˙158 €
 EC max contribution 202˙158 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Mitochondria play a vital role in the cellular machinery, hence it is little surprising that their dysfunction has been linked to many diseases, from diabetes to neurodegeneration. However, as many studies on the interplay of organelles and molecular dynamics often employ fluorescence microscopy, a continued worry overshadowing findings and deductions is the possibility that the transfection-induced overexpression of fluorescent proteins skews the obtained results. A recent approach, the gene editor CRISPR-CAS9, which modifies rather than adds DNA sequences, circumvents this issue, but in turn often reduces the available signal levels. To counter low signals and yet offer highest resolution and specificity, MitoQuant aims to image contextual mitochondrial information with label-free superresolution, while simultaneously enhance image quality of specific but sparse fluorescently labelled proteins of interest through recently presented de-noising routines based on machine learning. Therefore, the development of a novel instrument to provide adequate resolution and contrast, matching label-based live-cell superresolution techniques like structured illumination microscopy, is the first main goal of this project. The proposed microscope will work in the deep UV range and employ dedicated optics originally developed for material science to provide high numerical apertures at short wavelengths, thus enabling live-cell imaging in the 100nm range. Concurrently, a neural network will be compiled and trained to enhance signals under low-light conditions and to extract and classify cellular organelles based on their quantitative phase and autofluorescence information. Building on an excellent track record of developing application-tailored microscopes as well as advanced image reconstruction and processing algorithms particularly suited for live-cell superresolution, the researcher strives to start with first live-cell experiments in good time after establishing the technique.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MITOQUANT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MITOQUANT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

SIMIS (2020)

Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions

Read More  

GenEl (2020)

General readout electronics for cross-sectoral application in European research infrastructure

Read More  


Investigation of the SNP-induced RNA structure variations between subgenomes in polyploid wheat

Read More